Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/27463 https://doi.org/10.1016/j.foodchem.2013.08.034 |
Resumo: | Aiming at the development of an active food packaging, the goal of this study was to increase stilbenes (resveratrol (RV), pterostilbene (PT) and pinosylvin (PS)) aqueous solubility and stability using hydropropyl-cyclodextrins (HP-CDs) and bile salts. To evaluate stilbene concentration, an HPLC-DAD method was validated. Stilbene solubility was improved by the formation of inclusion complexes and micellar systems with higher solubility values obtained for the inclusion complexes with cyclodextrins. Inclusion complexes revealed a 1:1 stoichiometry for RV and PT and a 1:2 for PS. Solid state characterisation was carried out using X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry. 1H NMR studies were also performed to characterise the prepared complexes. Photostability studies revealed that CDs were able to increase stilbene photostability at 4 °C. This work showed that stable stilbene solutions can be achieved using hydroxypropyl-CDs, contributing for their incorporation in several materials for the food and pharmaceutical industries. |
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Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acidsStilbenesCyclodextrinsBile saltsHPLC-DADPhotostabilityInclusion complexesMicellesAiming at the development of an active food packaging, the goal of this study was to increase stilbenes (resveratrol (RV), pterostilbene (PT) and pinosylvin (PS)) aqueous solubility and stability using hydropropyl-cyclodextrins (HP-CDs) and bile salts. To evaluate stilbene concentration, an HPLC-DAD method was validated. Stilbene solubility was improved by the formation of inclusion complexes and micellar systems with higher solubility values obtained for the inclusion complexes with cyclodextrins. Inclusion complexes revealed a 1:1 stoichiometry for RV and PT and a 1:2 for PS. Solid state characterisation was carried out using X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry. 1H NMR studies were also performed to characterise the prepared complexes. Photostability studies revealed that CDs were able to increase stilbene photostability at 4 °C. This work showed that stable stilbene solutions can be achieved using hydroxypropyl-CDs, contributing for their incorporation in several materials for the food and pharmaceutical industries.Elsevier2014-02-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/27463http://hdl.handle.net/10316/27463https://doi.org/10.1016/j.foodchem.2013.08.034engSILVA, Filomena [et. al] - Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids. "Food Chemistry". ISSN 0308-8146. Vol. 145 (2014) p. 115-1250308-8146http://www.sciencedirect.com/science/article/pii/S0308814613011035Silva, FilomenaFigueiras, AnaGallardo, EugeniaNerín, CristinaDomingues, Fernanda C.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-05-25T07:47:46Zoai:estudogeral.uc.pt:10316/27463Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:49:59.491806Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids |
title |
Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids |
spellingShingle |
Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids Silva, Filomena Stilbenes Cyclodextrins Bile salts HPLC-DAD Photostability Inclusion complexes Micelles |
title_short |
Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids |
title_full |
Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids |
title_fullStr |
Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids |
title_full_unstemmed |
Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids |
title_sort |
Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids |
author |
Silva, Filomena |
author_facet |
Silva, Filomena Figueiras, Ana Gallardo, Eugenia Nerín, Cristina Domingues, Fernanda C. |
author_role |
author |
author2 |
Figueiras, Ana Gallardo, Eugenia Nerín, Cristina Domingues, Fernanda C. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva, Filomena Figueiras, Ana Gallardo, Eugenia Nerín, Cristina Domingues, Fernanda C. |
dc.subject.por.fl_str_mv |
Stilbenes Cyclodextrins Bile salts HPLC-DAD Photostability Inclusion complexes Micelles |
topic |
Stilbenes Cyclodextrins Bile salts HPLC-DAD Photostability Inclusion complexes Micelles |
description |
Aiming at the development of an active food packaging, the goal of this study was to increase stilbenes (resveratrol (RV), pterostilbene (PT) and pinosylvin (PS)) aqueous solubility and stability using hydropropyl-cyclodextrins (HP-CDs) and bile salts. To evaluate stilbene concentration, an HPLC-DAD method was validated. Stilbene solubility was improved by the formation of inclusion complexes and micellar systems with higher solubility values obtained for the inclusion complexes with cyclodextrins. Inclusion complexes revealed a 1:1 stoichiometry for RV and PT and a 1:2 for PS. Solid state characterisation was carried out using X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry. 1H NMR studies were also performed to characterise the prepared complexes. Photostability studies revealed that CDs were able to increase stilbene photostability at 4 °C. This work showed that stable stilbene solutions can be achieved using hydroxypropyl-CDs, contributing for their incorporation in several materials for the food and pharmaceutical industries. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-02-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/27463 http://hdl.handle.net/10316/27463 https://doi.org/10.1016/j.foodchem.2013.08.034 |
url |
http://hdl.handle.net/10316/27463 https://doi.org/10.1016/j.foodchem.2013.08.034 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
SILVA, Filomena [et. al] - Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids. "Food Chemistry". ISSN 0308-8146. Vol. 145 (2014) p. 115-125 0308-8146 http://www.sciencedirect.com/science/article/pii/S0308814613011035 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133781029814272 |