Study of partition of nitrazepam in bile salt micelles and the role of lecithin

Detalhes bibliográficos
Autor(a) principal: de Castro, Baltazar
Data de Publicação: 2001
Outros Autores: Gameiro, Paula, Guimarães, Carla, Lima, José L.F.C, Reis, Salette
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/8323
Resumo: The effect of trihydroxy (sodium cholate and sodium glycocholate) and dihydroxy (sodium deoxycholate and sodium glycodeoxycholate) bile salt micelles on the spectrophotometric properties and on the solubility of nitrazepam in aqueous solution, at 25.0°C and at ionic strength 0.1 M in sodium chloride, has been assessed. From the results obtained it was possible to calculate the partition coefficients (Kp) of nitrazepam between aqueous and micellar phases. The partition coefficients of nitrazepam have also been determined in mixed micelles of cholate or deoxycholate with lecithin (egg yolk phosphatidylcholine), which were used as a model of the gastrointestinal tract. Drug partition was found to depend on the bile acid (number of hydroxyl groups and conjugation with glycine), and our data indicate further that addition of lecithin to bile salt micelles decreases the values of the partition coefficients in the mixed micelles at physiological pH.
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spelling Study of partition of nitrazepam in bile salt micelles and the role of lecithinPartition coefficientsBile salt micellesSolubilityMixed micellesLecithinnitrazepamThe effect of trihydroxy (sodium cholate and sodium glycocholate) and dihydroxy (sodium deoxycholate and sodium glycodeoxycholate) bile salt micelles on the spectrophotometric properties and on the solubility of nitrazepam in aqueous solution, at 25.0°C and at ionic strength 0.1 M in sodium chloride, has been assessed. From the results obtained it was possible to calculate the partition coefficients (Kp) of nitrazepam between aqueous and micellar phases. The partition coefficients of nitrazepam have also been determined in mixed micelles of cholate or deoxycholate with lecithin (egg yolk phosphatidylcholine), which were used as a model of the gastrointestinal tract. Drug partition was found to depend on the bile acid (number of hydroxyl groups and conjugation with glycine), and our data indicate further that addition of lecithin to bile salt micelles decreases the values of the partition coefficients in the mixed micelles at physiological pH.Repositório Institucional da Universidade Fernando Pessoade Castro, BaltazarGameiro, PaulaGuimarães, CarlaLima, José L.F.CReis, Salette2019-12-24T10:03:24Z2001-01-01T00:00:00Z2001-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/8323eng10.1016/S0731-7085(00)00443-Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:07:43Zoai:bdigital.ufp.pt:10284/8323Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:45:13.285160Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Study of partition of nitrazepam in bile salt micelles and the role of lecithin
title Study of partition of nitrazepam in bile salt micelles and the role of lecithin
spellingShingle Study of partition of nitrazepam in bile salt micelles and the role of lecithin
de Castro, Baltazar
Partition coefficients
Bile salt micelles
Solubility
Mixed micelles
Lecithinnitrazepam
title_short Study of partition of nitrazepam in bile salt micelles and the role of lecithin
title_full Study of partition of nitrazepam in bile salt micelles and the role of lecithin
title_fullStr Study of partition of nitrazepam in bile salt micelles and the role of lecithin
title_full_unstemmed Study of partition of nitrazepam in bile salt micelles and the role of lecithin
title_sort Study of partition of nitrazepam in bile salt micelles and the role of lecithin
author de Castro, Baltazar
author_facet de Castro, Baltazar
Gameiro, Paula
Guimarães, Carla
Lima, José L.F.C
Reis, Salette
author_role author
author2 Gameiro, Paula
Guimarães, Carla
Lima, José L.F.C
Reis, Salette
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv de Castro, Baltazar
Gameiro, Paula
Guimarães, Carla
Lima, José L.F.C
Reis, Salette
dc.subject.por.fl_str_mv Partition coefficients
Bile salt micelles
Solubility
Mixed micelles
Lecithinnitrazepam
topic Partition coefficients
Bile salt micelles
Solubility
Mixed micelles
Lecithinnitrazepam
description The effect of trihydroxy (sodium cholate and sodium glycocholate) and dihydroxy (sodium deoxycholate and sodium glycodeoxycholate) bile salt micelles on the spectrophotometric properties and on the solubility of nitrazepam in aqueous solution, at 25.0°C and at ionic strength 0.1 M in sodium chloride, has been assessed. From the results obtained it was possible to calculate the partition coefficients (Kp) of nitrazepam between aqueous and micellar phases. The partition coefficients of nitrazepam have also been determined in mixed micelles of cholate or deoxycholate with lecithin (egg yolk phosphatidylcholine), which were used as a model of the gastrointestinal tract. Drug partition was found to depend on the bile acid (number of hydroxyl groups and conjugation with glycine), and our data indicate further that addition of lecithin to bile salt micelles decreases the values of the partition coefficients in the mixed micelles at physiological pH.
publishDate 2001
dc.date.none.fl_str_mv 2001-01-01T00:00:00Z
2001-01-01T00:00:00Z
2019-12-24T10:03:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/8323
url http://hdl.handle.net/10284/8323
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/S0731-7085(00)00443-X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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