Age-related pathways in cardiac regeneration : a role for lncRNAs?

Detalhes bibliográficos
Autor(a) principal: Santos, Francisco
Data de Publicação: 2021
Outros Autores: Correia, Magda, Nóbrega-Pereira, Sandrina, Bernardes de Jesus, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46553
Resumo: Copyright © 2021 Santos, Correia, Nóbrega-Pereira and Bernardes de Jesus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Age-related pathways in cardiac regeneration : a role for lncRNAs?HeartlncRNAsRegenerationReprogrammingTransdifferentiationCopyright © 2021 Santos, Correia, Nóbrega-Pereira and Bernardes de Jesus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Aging imposes a barrier for tissue regeneration. In the heart, aging leads to a severe rearrangement of the cardiac structure and function and to a subsequent increased risk of heart failure. An intricate network of distinct pathways contributes to age-related alterations during healthy heart aging and account for a higher susceptibility of heart disease. Our understanding of the systemic aging process has already led to the design of anti-aging strategies or to the adoption of protective interventions. Nevertheless, our understanding of the molecular determinants operating during cardiac aging or repair remains limited. Here, we will summarize the molecular and physiological alterations that occur during aging of the heart, highlighting the potential role for long non-coding RNAs (lncRNAs) as novel and valuable targets in cardiac regeneration/repair.This work was supported by Fundação para a Ciência e Tecnologia (FCT; ERA-CVD 2018 / 3599-PPCDT - ERA-CVD/0001/2018 - INNOVATION).FrontiersRepositório da Universidade de LisboaSantos, FranciscoCorreia, MagdaNóbrega-Pereira, SandrinaBernardes de Jesus, Bruno2021-02-26T16:40:17Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46553engFront Physiol. 2021 Jan 20;11:58319110.3389/fphys.2020.5831911664-042Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:54Zoai:repositorio.ul.pt:10451/46553Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:42.435015Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Age-related pathways in cardiac regeneration : a role for lncRNAs?
title Age-related pathways in cardiac regeneration : a role for lncRNAs?
spellingShingle Age-related pathways in cardiac regeneration : a role for lncRNAs?
Santos, Francisco
Heart
lncRNAs
Regeneration
Reprogramming
Transdifferentiation
title_short Age-related pathways in cardiac regeneration : a role for lncRNAs?
title_full Age-related pathways in cardiac regeneration : a role for lncRNAs?
title_fullStr Age-related pathways in cardiac regeneration : a role for lncRNAs?
title_full_unstemmed Age-related pathways in cardiac regeneration : a role for lncRNAs?
title_sort Age-related pathways in cardiac regeneration : a role for lncRNAs?
author Santos, Francisco
author_facet Santos, Francisco
Correia, Magda
Nóbrega-Pereira, Sandrina
Bernardes de Jesus, Bruno
author_role author
author2 Correia, Magda
Nóbrega-Pereira, Sandrina
Bernardes de Jesus, Bruno
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Santos, Francisco
Correia, Magda
Nóbrega-Pereira, Sandrina
Bernardes de Jesus, Bruno
dc.subject.por.fl_str_mv Heart
lncRNAs
Regeneration
Reprogramming
Transdifferentiation
topic Heart
lncRNAs
Regeneration
Reprogramming
Transdifferentiation
description Copyright © 2021 Santos, Correia, Nóbrega-Pereira and Bernardes de Jesus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-26T16:40:17Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46553
url http://hdl.handle.net/10451/46553
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Physiol. 2021 Jan 20;11:583191
10.3389/fphys.2020.583191
1664-042X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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