A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/9306 |
Resumo: | Twenty-five years after the first successful cultivation and isolation of Helicobacter pylori, the scientific community is still struggling to understand the way(s) this bacterium is transmitted among the human population. Here, both epidemiologic and microbiologic evidence addressing this matter is reviewed and explored to conclude that most H. pylori successful colonizations are derived from direct person-to-person contact and that even though exposure of humans to H. pylori from environmental sources is a very common event, in most occasions the host is able to fight off infection. In addition, under a new model developed here, we propose that the near elimination of environmental reservoirs is the main responsible for the lower prevalence observed in the more industrialized countries by acting on two levels: by decreasing the number of direct infections and by diminishing the number of intraspecies recombination events for producing strain variation within H. pylori. |
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A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversityHelicobacter pyloriEpidemiologyMicrobiologyWaterScience & TechnologyTwenty-five years after the first successful cultivation and isolation of Helicobacter pylori, the scientific community is still struggling to understand the way(s) this bacterium is transmitted among the human population. Here, both epidemiologic and microbiologic evidence addressing this matter is reviewed and explored to conclude that most H. pylori successful colonizations are derived from direct person-to-person contact and that even though exposure of humans to H. pylori from environmental sources is a very common event, in most occasions the host is able to fight off infection. In addition, under a new model developed here, we propose that the near elimination of environmental reservoirs is the main responsible for the lower prevalence observed in the more industrialized countries by acting on two levels: by decreasing the number of direct infections and by diminishing the number of intraspecies recombination events for producing strain variation within H. pylori.Informa HealthcareUniversidade do MinhoAzevedo, N. F.Guimarães, N.Figueiredo, C.Keevil, C. W.Vieira, M. J.20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/9306eng"Critical Reviews in Microbiology." ISSN 1040-841X. 33:3 ( 2007) 157-169.1040-841X10.1080/1040841070145192217653985http://www.informaworld.com/smpp/title~content=t713400901info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:43:01Zoai:repositorium.sdum.uminho.pt:1822/9306Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:40:24.902627Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity |
title |
A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity |
spellingShingle |
A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity Azevedo, N. F. Helicobacter pylori Epidemiology Microbiology Water Science & Technology |
title_short |
A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity |
title_full |
A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity |
title_fullStr |
A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity |
title_full_unstemmed |
A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity |
title_sort |
A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity |
author |
Azevedo, N. F. |
author_facet |
Azevedo, N. F. Guimarães, N. Figueiredo, C. Keevil, C. W. Vieira, M. J. |
author_role |
author |
author2 |
Guimarães, N. Figueiredo, C. Keevil, C. W. Vieira, M. J. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Azevedo, N. F. Guimarães, N. Figueiredo, C. Keevil, C. W. Vieira, M. J. |
dc.subject.por.fl_str_mv |
Helicobacter pylori Epidemiology Microbiology Water Science & Technology |
topic |
Helicobacter pylori Epidemiology Microbiology Water Science & Technology |
description |
Twenty-five years after the first successful cultivation and isolation of Helicobacter pylori, the scientific community is still struggling to understand the way(s) this bacterium is transmitted among the human population. Here, both epidemiologic and microbiologic evidence addressing this matter is reviewed and explored to conclude that most H. pylori successful colonizations are derived from direct person-to-person contact and that even though exposure of humans to H. pylori from environmental sources is a very common event, in most occasions the host is able to fight off infection. In addition, under a new model developed here, we propose that the near elimination of environmental reservoirs is the main responsible for the lower prevalence observed in the more industrialized countries by acting on two levels: by decreasing the number of direct infections and by diminishing the number of intraspecies recombination events for producing strain variation within H. pylori. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007 2007-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/9306 |
url |
http://hdl.handle.net/1822/9306 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
"Critical Reviews in Microbiology." ISSN 1040-841X. 33:3 ( 2007) 157-169. 1040-841X 10.1080/10408410701451922 17653985 http://www.informaworld.com/smpp/title~content=t713400901 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Informa Healthcare |
publisher.none.fl_str_mv |
Informa Healthcare |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132949734490112 |