Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust

Detalhes bibliográficos
Autor(a) principal: Viegas, Susana
Data de Publicação: 2017
Outros Autores: Caetano, Liliana Aranha, Korkalainen, Merja, Faria, Tiago, Pacífico, Cátia, Carolino, Elisabete, Gomes, Anita Q., Viegas, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/48644
Resumo: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dustOrganic dustOccupational exposureCytotoxic effectsInflammatory effectsIn vitro© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Organic dust and related microbial exposures are the main inducers of several respiratory symptoms. Occupational exposure to organic dust is very common and has been reported in diverse settings. In vitro tests using relevant cell cultures can be very useful for characterizing the toxicity of complex mixtures present in the air of occupational environments such as organic dust. In this study, the cell viability and the inflammatory response, as measured by the production of pro-inflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin-1 β (IL-1β), were determined in human macrophages derived from THP-1 monocytic cells. These cells were exposed to air samples from five occupational settings known to possess high levels of contamination of organic dust: poultry and swine feed industries, waste sorting, poultry production and slaughterhouses. Additionally, fungi and particle contamination of those settings was studied to better characterize the organic dust composition. All air samples collected from the assessed workplaces caused both cytotoxic and pro-inflammatory effects. The highest responses were observed in the feed industry, particularly in swine feed production. This study emphasizes the importance of measuring the organic dust/mixture effects in occupational settings and suggests that differences in the organic dust content may result in differences in health effects for exposed workers.MDPIRepositório da Universidade de LisboaViegas, SusanaCaetano, Liliana AranhaKorkalainen, MerjaFaria, TiagoPacífico, CátiaCarolino, ElisabeteGomes, Anita Q.Viegas, Carla2021-06-18T15:55:23Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48644engToxics. 2017 Mar 1;5(1):810.3390/toxics50100082305-6304info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:00Zoai:repositorio.ul.pt:10451/48644Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:25.551251Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust
title Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust
spellingShingle Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust
Viegas, Susana
Organic dust
Occupational exposure
Cytotoxic effects
Inflammatory effects
In vitro
title_short Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust
title_full Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust
title_fullStr Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust
title_full_unstemmed Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust
title_sort Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust
author Viegas, Susana
author_facet Viegas, Susana
Caetano, Liliana Aranha
Korkalainen, Merja
Faria, Tiago
Pacífico, Cátia
Carolino, Elisabete
Gomes, Anita Q.
Viegas, Carla
author_role author
author2 Caetano, Liliana Aranha
Korkalainen, Merja
Faria, Tiago
Pacífico, Cátia
Carolino, Elisabete
Gomes, Anita Q.
Viegas, Carla
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Viegas, Susana
Caetano, Liliana Aranha
Korkalainen, Merja
Faria, Tiago
Pacífico, Cátia
Carolino, Elisabete
Gomes, Anita Q.
Viegas, Carla
dc.subject.por.fl_str_mv Organic dust
Occupational exposure
Cytotoxic effects
Inflammatory effects
In vitro
topic Organic dust
Occupational exposure
Cytotoxic effects
Inflammatory effects
In vitro
description © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2021-06-18T15:55:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/48644
url http://hdl.handle.net/10451/48644
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxics. 2017 Mar 1;5(1):8
10.3390/toxics5010008
2305-6304
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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