Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/48644 |
Resumo: | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
id |
RCAP_3c2aa80bdc48474d5a5118533478ced5 |
---|---|
oai_identifier_str |
oai:repositorio.ul.pt:10451/48644 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dustOrganic dustOccupational exposureCytotoxic effectsInflammatory effectsIn vitro© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Organic dust and related microbial exposures are the main inducers of several respiratory symptoms. Occupational exposure to organic dust is very common and has been reported in diverse settings. In vitro tests using relevant cell cultures can be very useful for characterizing the toxicity of complex mixtures present in the air of occupational environments such as organic dust. In this study, the cell viability and the inflammatory response, as measured by the production of pro-inflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin-1 β (IL-1β), were determined in human macrophages derived from THP-1 monocytic cells. These cells were exposed to air samples from five occupational settings known to possess high levels of contamination of organic dust: poultry and swine feed industries, waste sorting, poultry production and slaughterhouses. Additionally, fungi and particle contamination of those settings was studied to better characterize the organic dust composition. All air samples collected from the assessed workplaces caused both cytotoxic and pro-inflammatory effects. The highest responses were observed in the feed industry, particularly in swine feed production. This study emphasizes the importance of measuring the organic dust/mixture effects in occupational settings and suggests that differences in the organic dust content may result in differences in health effects for exposed workers.MDPIRepositório da Universidade de LisboaViegas, SusanaCaetano, Liliana AranhaKorkalainen, MerjaFaria, TiagoPacífico, CátiaCarolino, ElisabeteGomes, Anita Q.Viegas, Carla2021-06-18T15:55:23Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48644engToxics. 2017 Mar 1;5(1):810.3390/toxics50100082305-6304info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:00Zoai:repositorio.ul.pt:10451/48644Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:25.551251Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust |
title |
Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust |
spellingShingle |
Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust Viegas, Susana Organic dust Occupational exposure Cytotoxic effects Inflammatory effects In vitro |
title_short |
Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust |
title_full |
Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust |
title_fullStr |
Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust |
title_full_unstemmed |
Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust |
title_sort |
Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust |
author |
Viegas, Susana |
author_facet |
Viegas, Susana Caetano, Liliana Aranha Korkalainen, Merja Faria, Tiago Pacífico, Cátia Carolino, Elisabete Gomes, Anita Q. Viegas, Carla |
author_role |
author |
author2 |
Caetano, Liliana Aranha Korkalainen, Merja Faria, Tiago Pacífico, Cátia Carolino, Elisabete Gomes, Anita Q. Viegas, Carla |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Viegas, Susana Caetano, Liliana Aranha Korkalainen, Merja Faria, Tiago Pacífico, Cátia Carolino, Elisabete Gomes, Anita Q. Viegas, Carla |
dc.subject.por.fl_str_mv |
Organic dust Occupational exposure Cytotoxic effects Inflammatory effects In vitro |
topic |
Organic dust Occupational exposure Cytotoxic effects Inflammatory effects In vitro |
description |
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2021-06-18T15:55:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/48644 |
url |
http://hdl.handle.net/10451/48644 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Toxics. 2017 Mar 1;5(1):8 10.3390/toxics5010008 2305-6304 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134551019094016 |