Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/24200 |
Resumo: | Since adult neurogenesis became a widely accepted phenomenon, much effort has been put in trying to understand the mechanisms involved in its regulation. In addition, the pathophysiology of several neuropsychiatric disorders, such as depression, has been associated with imbalances in adult hippocampal neurogenesis. These imbalances may ultimately reflect alterations at the cell cycle level, as a common mechanism through which intrinsic and extrinsic stimuli interact with the neurogenic niche properties. Thus, the comprehension of these regulatory mechanisms has become of major importance to disclose novel therapeutic targets. In this review, we first present a comprehensive view on the cell cycle components and mechanisms that were identified in the context of the homeostatic adult hippocampal neurogenic niche. Then, we focus on recent work regarding the cell cycle changes and signaling pathways that are responsible for the neurogenesis imbalances observed in neuropathological conditions, with a particular emphasis on depression. |
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Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depressionCell cycleCell signalingAdult hippocampal neurogenesisDepressionScience & TechnologySince adult neurogenesis became a widely accepted phenomenon, much effort has been put in trying to understand the mechanisms involved in its regulation. In addition, the pathophysiology of several neuropsychiatric disorders, such as depression, has been associated with imbalances in adult hippocampal neurogenesis. These imbalances may ultimately reflect alterations at the cell cycle level, as a common mechanism through which intrinsic and extrinsic stimuli interact with the neurogenic niche properties. Thus, the comprehension of these regulatory mechanisms has become of major importance to disclose novel therapeutic targets. In this review, we first present a comprehensive view on the cell cycle components and mechanisms that were identified in the context of the homeostatic adult hippocampal neurogenic niche. Then, we focus on recent work regarding the cell cycle changes and signaling pathways that are responsible for the neurogenesis imbalances observed in neuropathological conditions, with a particular emphasis on depression.SpringerUniversidade do MinhoPatrício, P.Pinheiro, António MateusSousa, NunoPinto, Luísa2013-032013-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24200engPatrício, P., Mateus-Pinheiro, A., Sousa, N. et al. Re-cycling Paradigms: Cell Cycle Regulation in Adult Hippocampal Neurogenesis and Implications for Depression. Mol Neurobiol 48, 84–96 (2013). https://doi.org/10.1007/s12035-013-8422-x0893-764810.1007/s12035-013-8422-x23471746http://dx.doi.org/10.1007/s12035-013-8422-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:32:56Zoai:repositorium.sdum.uminho.pt:1822/24200Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:28:21.945683Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression |
title |
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression |
spellingShingle |
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression Patrício, P. Cell cycle Cell signaling Adult hippocampal neurogenesis Depression Science & Technology |
title_short |
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression |
title_full |
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression |
title_fullStr |
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression |
title_full_unstemmed |
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression |
title_sort |
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression |
author |
Patrício, P. |
author_facet |
Patrício, P. Pinheiro, António Mateus Sousa, Nuno Pinto, Luísa |
author_role |
author |
author2 |
Pinheiro, António Mateus Sousa, Nuno Pinto, Luísa |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Patrício, P. Pinheiro, António Mateus Sousa, Nuno Pinto, Luísa |
dc.subject.por.fl_str_mv |
Cell cycle Cell signaling Adult hippocampal neurogenesis Depression Science & Technology |
topic |
Cell cycle Cell signaling Adult hippocampal neurogenesis Depression Science & Technology |
description |
Since adult neurogenesis became a widely accepted phenomenon, much effort has been put in trying to understand the mechanisms involved in its regulation. In addition, the pathophysiology of several neuropsychiatric disorders, such as depression, has been associated with imbalances in adult hippocampal neurogenesis. These imbalances may ultimately reflect alterations at the cell cycle level, as a common mechanism through which intrinsic and extrinsic stimuli interact with the neurogenic niche properties. Thus, the comprehension of these regulatory mechanisms has become of major importance to disclose novel therapeutic targets. In this review, we first present a comprehensive view on the cell cycle components and mechanisms that were identified in the context of the homeostatic adult hippocampal neurogenic niche. Then, we focus on recent work regarding the cell cycle changes and signaling pathways that are responsible for the neurogenesis imbalances observed in neuropathological conditions, with a particular emphasis on depression. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-03 2013-03-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/24200 |
url |
http://hdl.handle.net/1822/24200 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Patrício, P., Mateus-Pinheiro, A., Sousa, N. et al. Re-cycling Paradigms: Cell Cycle Regulation in Adult Hippocampal Neurogenesis and Implications for Depression. Mol Neurobiol 48, 84–96 (2013). https://doi.org/10.1007/s12035-013-8422-x 0893-7648 10.1007/s12035-013-8422-x 23471746 http://dx.doi.org/10.1007/s12035-013-8422-x |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132778862739456 |