Hippocampal Cb2 receptors: an untold story
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/45698 https://doi.org/10.1515/revneuro-2021-0109 |
Resumo: | The field of cannabinoid research has been receiving ever-growing interest. Ongoing debates worldwide about the legislation of medical cannabis further motivates research into cannabinoid function within the central nervous system (CNS). To date, two wellcharacterized cannabinoid receptors exist. While most research has investigated Cb1 receptors (Cb1Rs), Cb2 receptors (Cb2Rs) in the brain have started to attract considerable interest in recent years. With indisputable evidence showing the wide-distribution of Cb2Rs in the brain of different species, they are no longer considered just peripheral receptors. However, in contrast to Cb1Rs, the functionality of central Cb2Rs remains largely unexplored. Here we review recent studies on hippocampal Cb2Rs. While conflicting results about their function have been reported, we have made significant progress in understanding the involvement of Cb2Rs in modulating cellular properties and network excitability. Moreover, Cb2Rs have been shown to be expressed in different subregions of the hippocampus, challenging our prior understanding of the endocannabinoid system. Although more insight into their functional roles is necessary, we propose that targeting hippocampal Cb2Rs may offer novel therapies for diseases related to memory and adult neurogenesis deficits |
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Visvanathar, RobinPapanikolaou, MariaNôga, Diana AlineReis, Marina PáduaTort, Adriano Bretanha LopesBlunder, Martina2022-01-20T12:36:23Z2022-01-20T12:36:23Z2021-10-29VISVANATHAR, Robin; PAPANIKOLAOU, Maria; NÔGA, Diana Aline; PÁDUA-REIS, Marina; TORT, Adriano Bretanha Lopes; BLUNDER, Martina. Hippocampal Cb2 receptors: an untold story. Rev Neurosci., Berlin, p. 1-14, out. 2021. Doi: 10.1515/revneuro-2021-0109. Disponível em: https://www.degruyter.com/document/doi/10.1515/revneuro-2021-0109/html. Acesso em: 20 jan. 2022.https://repositorio.ufrn.br/handle/123456789/45698https://doi.org/10.1515/revneuro-2021-0109Adult neurogenesisCannabinoidsEndocannabinoid systemHippocampal Cb2 receptorsHippocampusMemoryHippocampal Cb2 receptors: an untold storyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe field of cannabinoid research has been receiving ever-growing interest. Ongoing debates worldwide about the legislation of medical cannabis further motivates research into cannabinoid function within the central nervous system (CNS). To date, two wellcharacterized cannabinoid receptors exist. While most research has investigated Cb1 receptors (Cb1Rs), Cb2 receptors (Cb2Rs) in the brain have started to attract considerable interest in recent years. With indisputable evidence showing the wide-distribution of Cb2Rs in the brain of different species, they are no longer considered just peripheral receptors. However, in contrast to Cb1Rs, the functionality of central Cb2Rs remains largely unexplored. Here we review recent studies on hippocampal Cb2Rs. While conflicting results about their function have been reported, we have made significant progress in understanding the involvement of Cb2Rs in modulating cellular properties and network excitability. Moreover, Cb2Rs have been shown to be expressed in different subregions of the hippocampus, challenging our prior understanding of the endocannabinoid system. Although more insight into their functional roles is necessary, we propose that targeting hippocampal Cb2Rs may offer novel therapies for diseases related to memory and adult neurogenesis deficitsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALHippocampalCb2Receptors_Tort_2021.pdfHippocampalCb2Receptors_Tort_2021.pdfapplication/pdf1321285https://repositorio.ufrn.br/bitstream/123456789/45698/1/HippocampalCb2Receptors_Tort_2021.pdf57e5d746f3d71fa816b545cfeca33e70MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/45698/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52123456789/456982022-01-20 09:36:25.349oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-01-20T12:36:25Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Hippocampal Cb2 receptors: an untold story |
title |
Hippocampal Cb2 receptors: an untold story |
spellingShingle |
Hippocampal Cb2 receptors: an untold story Visvanathar, Robin Adult neurogenesis Cannabinoids Endocannabinoid system Hippocampal Cb2 receptors Hippocampus Memory |
title_short |
Hippocampal Cb2 receptors: an untold story |
title_full |
Hippocampal Cb2 receptors: an untold story |
title_fullStr |
Hippocampal Cb2 receptors: an untold story |
title_full_unstemmed |
Hippocampal Cb2 receptors: an untold story |
title_sort |
Hippocampal Cb2 receptors: an untold story |
author |
Visvanathar, Robin |
author_facet |
Visvanathar, Robin Papanikolaou, Maria Nôga, Diana Aline Reis, Marina Pádua Tort, Adriano Bretanha Lopes Blunder, Martina |
author_role |
author |
author2 |
Papanikolaou, Maria Nôga, Diana Aline Reis, Marina Pádua Tort, Adriano Bretanha Lopes Blunder, Martina |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Visvanathar, Robin Papanikolaou, Maria Nôga, Diana Aline Reis, Marina Pádua Tort, Adriano Bretanha Lopes Blunder, Martina |
dc.subject.por.fl_str_mv |
Adult neurogenesis Cannabinoids Endocannabinoid system Hippocampal Cb2 receptors Hippocampus Memory |
topic |
Adult neurogenesis Cannabinoids Endocannabinoid system Hippocampal Cb2 receptors Hippocampus Memory |
description |
The field of cannabinoid research has been receiving ever-growing interest. Ongoing debates worldwide about the legislation of medical cannabis further motivates research into cannabinoid function within the central nervous system (CNS). To date, two wellcharacterized cannabinoid receptors exist. While most research has investigated Cb1 receptors (Cb1Rs), Cb2 receptors (Cb2Rs) in the brain have started to attract considerable interest in recent years. With indisputable evidence showing the wide-distribution of Cb2Rs in the brain of different species, they are no longer considered just peripheral receptors. However, in contrast to Cb1Rs, the functionality of central Cb2Rs remains largely unexplored. Here we review recent studies on hippocampal Cb2Rs. While conflicting results about their function have been reported, we have made significant progress in understanding the involvement of Cb2Rs in modulating cellular properties and network excitability. Moreover, Cb2Rs have been shown to be expressed in different subregions of the hippocampus, challenging our prior understanding of the endocannabinoid system. Although more insight into their functional roles is necessary, we propose that targeting hippocampal Cb2Rs may offer novel therapies for diseases related to memory and adult neurogenesis deficits |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-10-29 |
dc.date.accessioned.fl_str_mv |
2022-01-20T12:36:23Z |
dc.date.available.fl_str_mv |
2022-01-20T12:36:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VISVANATHAR, Robin; PAPANIKOLAOU, Maria; NÔGA, Diana Aline; PÁDUA-REIS, Marina; TORT, Adriano Bretanha Lopes; BLUNDER, Martina. Hippocampal Cb2 receptors: an untold story. Rev Neurosci., Berlin, p. 1-14, out. 2021. Doi: 10.1515/revneuro-2021-0109. Disponível em: https://www.degruyter.com/document/doi/10.1515/revneuro-2021-0109/html. Acesso em: 20 jan. 2022. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/45698 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1515/revneuro-2021-0109 |
identifier_str_mv |
VISVANATHAR, Robin; PAPANIKOLAOU, Maria; NÔGA, Diana Aline; PÁDUA-REIS, Marina; TORT, Adriano Bretanha Lopes; BLUNDER, Martina. Hippocampal Cb2 receptors: an untold story. Rev Neurosci., Berlin, p. 1-14, out. 2021. Doi: 10.1515/revneuro-2021-0109. Disponível em: https://www.degruyter.com/document/doi/10.1515/revneuro-2021-0109/html. Acesso em: 20 jan. 2022. |
url |
https://repositorio.ufrn.br/handle/123456789/45698 https://doi.org/10.1515/revneuro-2021-0109 |
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eng |
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