Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infections

Detalhes bibliográficos
Autor(a) principal: Martins, Elisabete R.
Data de Publicação: 2022
Outros Autores: Nascimento do Ó, Dulce, Marques Costa, Ana Luísa, Cristino, José Melo, Ramirez, Mário
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/53165
Resumo: Copyright © 2022 Martins et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
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spelling Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infectionsStreptococcus agalactiaeAntimicrobial resistanceCarriageCase-carrier ratioClonesColonizationGroup B StreptococcusInvasive diseaseMultilocus sequence typingNonpregnant adultsSerotypeCopyright © 2022 Martins et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.The prevalence and lineages of Streptococcus agalactiae (group B streptococci [GBS]) colonizing pregnant women are well studied, but less is known about colonization of nonpregnant adults. We characterized GBS colonization in adults as a potential reservoir for infections and tested for the presence of clones with a potentially higher invasive disease potential. We evaluated GBS gastrointestinal, genitourinary, and oral colonization among 336 nonpregnant adults in the community. We characterized the isolates by serotyping, multilocus sequence typing, profiling of surface protein genes and pili, and antimicrobial susceptibility and compared them with contemporary invasive isolates. The colonization rate (n = 107, 32%) among nonpregnant adults was like that of pregnant women. Colonization increased with age (~25% in the 18 to 29 and 30 to 44 years old groups and >42% in the ≥60 years old group), potentially explaining the higher incidence of disease with older age. Participants who were colonized at multiple sites (73%) were frequently carrying indistinguishable strains (93%), consistent with the existence of a single reservoir of colonization and transfer of GBS between sites within the same individual. The most frequent lineages found were serotype Ib/CC1 (n = 27), serotype V/CC1 (n = 19), serotype Ia/CC23 (n = 13), serotype III/ST17 (n = 13), and serotype Ib/CC10 (n = 11). Comparison with contemporary isolates causing invasive infections in Portugal did not reveal any lineage associated with either asymptomatic carriage or invasive disease. Asymptomatic colonization of nonpregnant adults is significant and could act as a reservoir for invasive disease, but in contrast to infant disease, we found no GBS lineages with an enhanced potential for causing invasive disease in adults. IMPORTANCE The increasing incidence of Streptococcus agalactiae (group B streptococci [GBS]) infections in adults and the inability of antimicrobial prophylaxis peripartum to control late-onset infections in infants motivate the study of the asymptomatic carrier state in nonpregnant adults. We found an overall carriage rate like that of pregnant women, increasing with age, potentially contributing to the higher incidence of GBS infections with age. Colonization of diabetic participants was not higher despite the higher number of infections in this group. Comparison between contemporary genetic lineages causing infections and found in asymptomatic carriers did not identify particularly virulent lineages. This means that any prophylactic approaches targeting colonization by particular lineages are expected to have a limited impact on GBS disease in adults.ERM was supported by Fundação para a Ciência e a Tecnologia (SFRH/BPD/80038/2011 and DL57/2016/CP1451/CT0009).ASM JournalsRepositório da Universidade de LisboaMartins, Elisabete R.Nascimento do Ó, DulceMarques Costa, Ana LuísaCristino, José MeloRamirez, Mário2022-05-24T15:00:42Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53165engMicrobiol Spectr. 2022 May 23;e010822210.1128/spectrum.01082-222165-0497info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:49Zoai:repositorio.ul.pt:10451/53165Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:08.205008Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infections
title Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infections
spellingShingle Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infections
Martins, Elisabete R.
Streptococcus agalactiae
Antimicrobial resistance
Carriage
Case-carrier ratio
Clones
Colonization
Group B Streptococcus
Invasive disease
Multilocus sequence typing
Nonpregnant adults
Serotype
title_short Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infections
title_full Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infections
title_fullStr Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infections
title_full_unstemmed Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infections
title_sort Characteristics of Streptococcus agalactiae colonizing nonpregnant adults support the opportunistic nature of invasive infections
author Martins, Elisabete R.
author_facet Martins, Elisabete R.
Nascimento do Ó, Dulce
Marques Costa, Ana Luísa
Cristino, José Melo
Ramirez, Mário
author_role author
author2 Nascimento do Ó, Dulce
Marques Costa, Ana Luísa
Cristino, José Melo
Ramirez, Mário
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Martins, Elisabete R.
Nascimento do Ó, Dulce
Marques Costa, Ana Luísa
Cristino, José Melo
Ramirez, Mário
dc.subject.por.fl_str_mv Streptococcus agalactiae
Antimicrobial resistance
Carriage
Case-carrier ratio
Clones
Colonization
Group B Streptococcus
Invasive disease
Multilocus sequence typing
Nonpregnant adults
Serotype
topic Streptococcus agalactiae
Antimicrobial resistance
Carriage
Case-carrier ratio
Clones
Colonization
Group B Streptococcus
Invasive disease
Multilocus sequence typing
Nonpregnant adults
Serotype
description Copyright © 2022 Martins et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-24T15:00:42Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/53165
url http://hdl.handle.net/10451/53165
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microbiol Spectr. 2022 May 23;e0108222
10.1128/spectrum.01082-22
2165-0497
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ASM Journals
publisher.none.fl_str_mv ASM Journals
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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