Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.23/575 |
Resumo: | INTRODUCTION: Chronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis. CLINICAL CASES: Case 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy. Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution. CONCLUSION: GD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical casesDoença Granulomatosa CrónicaImunodeficiência de Variável ComumINTRODUCTION: Chronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis. CLINICAL CASES: Case 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy. Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution. CONCLUSION: GD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge.Sociedade Portuguesa de PneumologiaRepositório Científico do Hospital de BragaPacheco, CMorais, ARolo, RFerreira, LNabiço, RCunha, J2014-02-14T12:50:43Z2014-01-01T00:00:00Z2014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/575engRev Port Pneumol. 2014 Jan 22. pii: S0873-2159(13)00159-1.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:02:16ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases |
title |
Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases |
spellingShingle |
Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases Pacheco, C Doença Granulomatosa Crónica Imunodeficiência de Variável Comum |
title_short |
Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases |
title_full |
Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases |
title_fullStr |
Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases |
title_full_unstemmed |
Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases |
title_sort |
Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases |
author |
Pacheco, C |
author_facet |
Pacheco, C Morais, A Rolo, R Ferreira, L Nabiço, R Cunha, J |
author_role |
author |
author2 |
Morais, A Rolo, R Ferreira, L Nabiço, R Cunha, J |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Hospital de Braga |
dc.contributor.author.fl_str_mv |
Pacheco, C Morais, A Rolo, R Ferreira, L Nabiço, R Cunha, J |
dc.subject.por.fl_str_mv |
Doença Granulomatosa Crónica Imunodeficiência de Variável Comum |
topic |
Doença Granulomatosa Crónica Imunodeficiência de Variável Comum |
description |
INTRODUCTION: Chronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis. CLINICAL CASES: Case 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy. Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution. CONCLUSION: GD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-02-14T12:50:43Z 2014-01-01T00:00:00Z 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.23/575 |
url |
http://hdl.handle.net/10400.23/575 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rev Port Pneumol. 2014 Jan 22. pii: S0873-2159(13)00159-1. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Pneumologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Pneumologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777301470128898048 |