Emerging tumor spheroids technologies for 3D in vitro cancer modeling

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Tânia
Data de Publicação: 2018
Outros Autores: Kundu, Banani, Silva-Correia, Joana, Kundu, Subhas C, Oliveira, J. M., Reis, R. L., Correlo, V. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/51321
Resumo: "Article in Press, Available online 31 October 2017" ; "S0163-7258(17)30268-1"
id RCAP_3dc75da9c28fa2ed0c8f5b7f32b15189
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/51321
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Emerging tumor spheroids technologies for 3D in vitro cancer modelingMetastasis3D Tumor ModelsMulticellular Tumor SpheroidsBioprintingBiomaterialsScience & Technology"Article in Press, Available online 31 October 2017" ; "S0163-7258(17)30268-1"Cancer is a leading cause of mortality and morbidity worldwide. Around 90% of deaths are caused by metastasis and just 10% by primary tumor. The advancement of treatment approaches is not at the same rhythm of the disease; making cancer a focal target of biomedical research. To enhance the understanding and promts the therapeutic delivery; concepts of tissue engineering are applied in the development of in vitro models that can bridge between 2D cell culture and animal models, mimicking tissue microenvironment. Tumor spheroid represents highly suitable 3D organoid-like framework elucidiating the intra and inter cellular signaling of cancer, like that formed in physiological niche. However, spheroids are of limited value in studying critical biological phenomenon such as tumor-stroma interactons involving extra cellular matrix or immune system. Therefore, a compelling need of tailoring spheroid technologies with physiologically relevant biomaterials or in silico models, is ever emerging. The diagnostic and prognostic role of spheroids rearrangements within biomaterials or microfluidic channel is indicative of patient management; particularly for the decision of targated therapy. Fragmented information on available in vitro spheroid models and lack of critical analysis on transformation aspects of these strategies; pushes the urge to comprehensively overview the recent technological advancements (e.g. bioprinting, micro-fluidic technologies or use of biomaterials to attain the third dimension) in the shed of tranlationable cancer research. In present article, relationships between current models and their possible exploitation in clinical success is explored with the highlight of existing challenges in defining therapeutic targets and screening of drug efficacy.The authors are thankful to European Union (Horizon 2020) funded project FoReCaST (No. 668983), the FCT fellowship to J. Silva-Correia (Grant No. SFRH/BPD/100590/2014), distinctions to J.M.O. under the Investigator FCT program (IF/00423/2012) and V.M.C. under the Investigator FCT program (IF/01214/2014) for supporting this work financially.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoRodrigues, TâniaKundu, BananiSilva-Correia, JoanaKundu, Subhas COliveira, J. M.Reis, R. L.Correlo, V. M.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/51321engRodrigues T., Kundu B., Silva-Correia J., Kundu S. C., Oliveira J. M., Reis R. L., Correlo V. M. Emerging tumor spheroids technologies for 3D in vitro cancer modeling, Pharmacology & Therapeutics, doi:10.1016/j.pharmthera.2017.10.018, 2018.0163-72581879-016X10.1016/j.pharmthera.2017.10.01829097309https://doi.org/10.1016/j.pharmthera.2017.10.018info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:02:11Zoai:repositorium.sdum.uminho.pt:1822/51321Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:52:08.510153Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title Emerging tumor spheroids technologies for 3D in vitro cancer modeling
spellingShingle Emerging tumor spheroids technologies for 3D in vitro cancer modeling
Rodrigues, Tânia
Metastasis
3D Tumor Models
Multicellular Tumor Spheroids
Bioprinting
Biomaterials
Science & Technology
title_short Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title_full Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title_fullStr Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title_full_unstemmed Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title_sort Emerging tumor spheroids technologies for 3D in vitro cancer modeling
author Rodrigues, Tânia
author_facet Rodrigues, Tânia
Kundu, Banani
Silva-Correia, Joana
Kundu, Subhas C
Oliveira, J. M.
Reis, R. L.
Correlo, V. M.
author_role author
author2 Kundu, Banani
Silva-Correia, Joana
Kundu, Subhas C
Oliveira, J. M.
Reis, R. L.
Correlo, V. M.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodrigues, Tânia
Kundu, Banani
Silva-Correia, Joana
Kundu, Subhas C
Oliveira, J. M.
Reis, R. L.
Correlo, V. M.
dc.subject.por.fl_str_mv Metastasis
3D Tumor Models
Multicellular Tumor Spheroids
Bioprinting
Biomaterials
Science & Technology
topic Metastasis
3D Tumor Models
Multicellular Tumor Spheroids
Bioprinting
Biomaterials
Science & Technology
description "Article in Press, Available online 31 October 2017" ; "S0163-7258(17)30268-1"
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/51321
url http://hdl.handle.net/1822/51321
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues T., Kundu B., Silva-Correia J., Kundu S. C., Oliveira J. M., Reis R. L., Correlo V. M. Emerging tumor spheroids technologies for 3D in vitro cancer modeling, Pharmacology & Therapeutics, doi:10.1016/j.pharmthera.2017.10.018, 2018.
0163-7258
1879-016X
10.1016/j.pharmthera.2017.10.018
29097309
https://doi.org/10.1016/j.pharmthera.2017.10.018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132296160215040

Registros relacionados