The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/33218 https://doi.org/Rato L, Sousa ACA (2021) The impact of endocrine-disrupting chemicals in male fertility: focus on the action of obesogens. Journal of Xenobiotics 11, 163–196; Feature Paper https://doi.org/10.3390/jox11040012 https://doi.org/10.3390/jox11040012 |
Resumo: | The current scenario of male infertility is not yet fully elucidated; however, there is increasing evidence that it is associated with the widespread exposure to endocrine-disrupting chemicals (EDCs), and in particular to obesogens. These compounds interfere with hormones involved in the regulation of metabolism and are associated with weight gain, being also able to change the functioning of the male reproductive axis and, consequently, the testicular physiology and metabolism that are pivotal for spermatogenesis. The disruption of these tightly regulated metabolic pathways leads to adverse reproductive outcomes. The permanent exposure to obesogens has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline of male fertility and key players in shaping the future health outcomes not only for those who are directly exposed but also for upcoming generations. In addition to the changes that lead to inefficient functioning of the male gametes, obesogens induce alterations that are “imprinted” on the genes of the male gametes, establishing a link between generations and contributing to the transmission of defects. Unveiling the molecular mechanisms by which obesogens induce toxicity that may end-up in epigenetic modifications is imperative. This review describes and discusses the suggested molecular targets and potential mechanisms for obesogenic–disrupting chemicals and the subsequent effects on male reproductive health. |
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The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogensenvironmental contaminantsgerm cellsSertoli cellssperm qualityspermatogenesisreproductive axisobesogensinfertilityThe current scenario of male infertility is not yet fully elucidated; however, there is increasing evidence that it is associated with the widespread exposure to endocrine-disrupting chemicals (EDCs), and in particular to obesogens. These compounds interfere with hormones involved in the regulation of metabolism and are associated with weight gain, being also able to change the functioning of the male reproductive axis and, consequently, the testicular physiology and metabolism that are pivotal for spermatogenesis. The disruption of these tightly regulated metabolic pathways leads to adverse reproductive outcomes. The permanent exposure to obesogens has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline of male fertility and key players in shaping the future health outcomes not only for those who are directly exposed but also for upcoming generations. In addition to the changes that lead to inefficient functioning of the male gametes, obesogens induce alterations that are “imprinted” on the genes of the male gametes, establishing a link between generations and contributing to the transmission of defects. Unveiling the molecular mechanisms by which obesogens induce toxicity that may end-up in epigenetic modifications is imperative. This review describes and discusses the suggested molecular targets and potential mechanisms for obesogenic–disrupting chemicals and the subsequent effects on male reproductive health.MDPI2023-01-06T11:12:32Z2023-01-062021-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/33218https://doi.org/Rato L, Sousa ACA (2021) The impact of endocrine-disrupting chemicals in male fertility: focus on the action of obesogens. Journal of Xenobiotics 11, 163–196; Feature Paper https://doi.org/10.3390/jox11040012http://hdl.handle.net/10174/33218https://doi.org/10.3390/jox11040012enghttps://www.mdpi.com/2039-4713/11/4/12CHRC, DCMSndacsousa@uevora.pt239Rato, LuisSousa, Ana Catarinainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:34:49Zoai:dspace.uevora.pt:10174/33218Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:22:06.153872Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens |
title |
The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens |
spellingShingle |
The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens Rato, Luis environmental contaminants germ cells Sertoli cells sperm quality spermatogenesis reproductive axis obesogens infertility |
title_short |
The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens |
title_full |
The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens |
title_fullStr |
The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens |
title_full_unstemmed |
The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens |
title_sort |
The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens |
author |
Rato, Luis |
author_facet |
Rato, Luis Sousa, Ana Catarina |
author_role |
author |
author2 |
Sousa, Ana Catarina |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Rato, Luis Sousa, Ana Catarina |
dc.subject.por.fl_str_mv |
environmental contaminants germ cells Sertoli cells sperm quality spermatogenesis reproductive axis obesogens infertility |
topic |
environmental contaminants germ cells Sertoli cells sperm quality spermatogenesis reproductive axis obesogens infertility |
description |
The current scenario of male infertility is not yet fully elucidated; however, there is increasing evidence that it is associated with the widespread exposure to endocrine-disrupting chemicals (EDCs), and in particular to obesogens. These compounds interfere with hormones involved in the regulation of metabolism and are associated with weight gain, being also able to change the functioning of the male reproductive axis and, consequently, the testicular physiology and metabolism that are pivotal for spermatogenesis. The disruption of these tightly regulated metabolic pathways leads to adverse reproductive outcomes. The permanent exposure to obesogens has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline of male fertility and key players in shaping the future health outcomes not only for those who are directly exposed but also for upcoming generations. In addition to the changes that lead to inefficient functioning of the male gametes, obesogens induce alterations that are “imprinted” on the genes of the male gametes, establishing a link between generations and contributing to the transmission of defects. Unveiling the molecular mechanisms by which obesogens induce toxicity that may end-up in epigenetic modifications is imperative. This review describes and discusses the suggested molecular targets and potential mechanisms for obesogenic–disrupting chemicals and the subsequent effects on male reproductive health. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-01T00:00:00Z 2023-01-06T11:12:32Z 2023-01-06 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/33218 https://doi.org/Rato L, Sousa ACA (2021) The impact of endocrine-disrupting chemicals in male fertility: focus on the action of obesogens. Journal of Xenobiotics 11, 163–196; Feature Paper https://doi.org/10.3390/jox11040012 http://hdl.handle.net/10174/33218 https://doi.org/10.3390/jox11040012 |
url |
http://hdl.handle.net/10174/33218 https://doi.org/Rato L, Sousa ACA (2021) The impact of endocrine-disrupting chemicals in male fertility: focus on the action of obesogens. Journal of Xenobiotics 11, 163–196; Feature Paper https://doi.org/10.3390/jox11040012 https://doi.org/10.3390/jox11040012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.mdpi.com/2039-4713/11/4/12 CHRC, DCMS nd acsousa@uevora.pt 239 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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