Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle

Detalhes bibliográficos
Autor(a) principal: Murta, Daniel
Data de Publicação: 2013
Outros Autores: Batista, Marta, Silva, Elisabete, Trindade, Alexandre, Henrique, Domingos, Duarte, António, Lopes da Costa, Luís
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/7310
Resumo: Articles in International Journals
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spelling Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycleGerm cellsImmunostainingNotch signalingSertoli cellsSpermatidsSpermatocytesSpermatogenesisSpermatogoniaArticles in International JournalsThe transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key moments of post-natal development, and along the adult spermatogenic cycle. Notch pathway components and effectors are transcribed in the testis and expressed in germ, Sertoli and Leydig cells, and each Notch component shows a specific cell-type and timewindow expression pattern. This expression at key testis developmental events prompt for a role of Notch signaling in prepubertal spermatogonia quiescence, onset of spermatogenesis, and regulation of the spermatogenic cycle.Jean-Marc A. Lobaccaro, Clermont Université , FranceRepositório da Universidade de LisboaMurta, DanielBatista, MartaSilva, ElisabeteTrindade, AlexandreHenrique, DomingosDuarte, AntónioLopes da Costa, Luís2014-10-14T11:18:52Z2013-08-282013-08-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/7310engMurta, D., Batista, M., Silva, E., Trindade, A., Henrique, D., Duarte, A. et al. (2013). Dynamics of Notch Pathway Expression during Mouse Testis Post-Natal Development and along the Spermatogenic Cycle. PLoS ONE 8(8): e72767. doi:10.1371/journal.pone.00727671932-6203 (online)10.1371/journal.pone.0072767info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:38:02Zoai:www.repository.utl.pt:10400.5/7310Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:54:30.875854Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
title Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
spellingShingle Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
Murta, Daniel
Germ cells
Immunostaining
Notch signaling
Sertoli cells
Spermatids
Spermatocytes
Spermatogenesis
Spermatogonia
title_short Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
title_full Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
title_fullStr Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
title_full_unstemmed Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
title_sort Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
author Murta, Daniel
author_facet Murta, Daniel
Batista, Marta
Silva, Elisabete
Trindade, Alexandre
Henrique, Domingos
Duarte, António
Lopes da Costa, Luís
author_role author
author2 Batista, Marta
Silva, Elisabete
Trindade, Alexandre
Henrique, Domingos
Duarte, António
Lopes da Costa, Luís
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Murta, Daniel
Batista, Marta
Silva, Elisabete
Trindade, Alexandre
Henrique, Domingos
Duarte, António
Lopes da Costa, Luís
dc.subject.por.fl_str_mv Germ cells
Immunostaining
Notch signaling
Sertoli cells
Spermatids
Spermatocytes
Spermatogenesis
Spermatogonia
topic Germ cells
Immunostaining
Notch signaling
Sertoli cells
Spermatids
Spermatocytes
Spermatogenesis
Spermatogonia
description Articles in International Journals
publishDate 2013
dc.date.none.fl_str_mv 2013-08-28
2013-08-28T00:00:00Z
2014-10-14T11:18:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/7310
url http://hdl.handle.net/10400.5/7310
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Murta, D., Batista, M., Silva, E., Trindade, A., Henrique, D., Duarte, A. et al. (2013). Dynamics of Notch Pathway Expression during Mouse Testis Post-Natal Development and along the Spermatogenic Cycle. PLoS ONE 8(8): e72767. doi:10.1371/journal.pone.0072767
1932-6203 (online)
10.1371/journal.pone.0072767
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Jean-Marc A. Lobaccaro, Clermont Université , France
publisher.none.fl_str_mv Jean-Marc A. Lobaccaro, Clermont Université , France
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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