Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/61376 |
Resumo: | The eye presents extensive perspectives and challenges for drug delivery, mainly because of the extraordinary capacity, intrinsic to this path, for drugs to permeate into the main circulatory system and also for the restrictions of the ocular barriers. Depending on the target segment of the eye, anterior or posterior, the specifications are different. The ocular route experienced in the last decades a lot of progresses related with the development of new drugs, improved formulations, specific-designed delivery and even new routes to administer a drug. Concomitantly, new categories of materials were developed and adapted to encapsulate drugs. With such advances, a multiplicity of parameters became possible to be optimized as the increase in bioavailability and decreased toxic effects of medicines. Also, the formulations were capable to easily adhere to specific tissues, increase the duration of the therapeutic effect and even target the delivery of the treatment. The ascending of new delivery systems for ocular targeting is a current focus, mainly because of the capacity to extend the normal time during which the drug exerts its therapeutic effect and, so, supplying the patients with a product which gives them fewer side effects, fewer number of applications and even more effective outcomes to their pathologies, surpassing the traditionally-used eye drops. Depending on the systems, some are capable of increasing the duration of the drug action as gels, emulsions, prodrugs, liposomes, and ocular inserts with hydrophilic properties, improving the absorption by the cornea. In parallel, other devices use as a strategy the capacity to sustain the release of the carried drugs by means of erodible and non-erodible matrices. This review discusses the different types of advanced formulations used for ocular delivery of therapeutics presenting the most recent patents according to the clinical applications. |
id |
RCAP_3f381f03007485557a499e4a06ab1519 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/61376 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patentsocular drug deliverypatentsbioavailabilityanterior eye segmentposterior eye segmenttargeted drug deliveryScience & TechnologyThe eye presents extensive perspectives and challenges for drug delivery, mainly because of the extraordinary capacity, intrinsic to this path, for drugs to permeate into the main circulatory system and also for the restrictions of the ocular barriers. Depending on the target segment of the eye, anterior or posterior, the specifications are different. The ocular route experienced in the last decades a lot of progresses related with the development of new drugs, improved formulations, specific-designed delivery and even new routes to administer a drug. Concomitantly, new categories of materials were developed and adapted to encapsulate drugs. With such advances, a multiplicity of parameters became possible to be optimized as the increase in bioavailability and decreased toxic effects of medicines. Also, the formulations were capable to easily adhere to specific tissues, increase the duration of the therapeutic effect and even target the delivery of the treatment. The ascending of new delivery systems for ocular targeting is a current focus, mainly because of the capacity to extend the normal time during which the drug exerts its therapeutic effect and, so, supplying the patients with a product which gives them fewer side effects, fewer number of applications and even more effective outcomes to their pathologies, surpassing the traditionally-used eye drops. Depending on the systems, some are capable of increasing the duration of the drug action as gels, emulsions, prodrugs, liposomes, and ocular inserts with hydrophilic properties, improving the absorption by the cornea. In parallel, other devices use as a strategy the capacity to sustain the release of the carried drugs by means of erodible and non-erodible matrices. This review discusses the different types of advanced formulations used for ocular delivery of therapeutics presenting the most recent patents according to the clinical applications.This research was funded by the Institute of Nanoscience and Nanotechnology under the project(IN2UB ART2018) and by the Portuguese Science and Technology Foundation, Ministry of Science and Education(FCT/MEC) through national funds, under the project reference M-ERA-NET/0004/2015 (PAIRED), co-financed byFEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoSouto, Eliana B.Dias-Ferreira, JoãoLópez-Machado, AnaEttcheto, MirenCano, AmandaCamins Espuny, AntonioEspina, MartaGarcia, Maria LuisaSánchez-López, Elena20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61376engSouto, Eliana; Dias-Ferreira, João; López-Machado, Ana; Ettcheto, Miren; Cano, Amanda; Camins Espuny, Antonio; Espina, Marta; Garcia, Maria Luisa; Sánchez-López, Elena, Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents. Pharmaceutics, 11(9), 460, 20191999-492310.3390/pharmaceutics11090460info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:17:24Zoai:repositorium.sdum.uminho.pt:1822/61376Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:10:01.279260Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents |
title |
Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents |
spellingShingle |
Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents Souto, Eliana B. ocular drug delivery patents bioavailability anterior eye segment posterior eye segment targeted drug delivery Science & Technology |
title_short |
Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents |
title_full |
Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents |
title_fullStr |
Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents |
title_full_unstemmed |
Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents |
title_sort |
Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents |
author |
Souto, Eliana B. |
author_facet |
Souto, Eliana B. Dias-Ferreira, João López-Machado, Ana Ettcheto, Miren Cano, Amanda Camins Espuny, Antonio Espina, Marta Garcia, Maria Luisa Sánchez-López, Elena |
author_role |
author |
author2 |
Dias-Ferreira, João López-Machado, Ana Ettcheto, Miren Cano, Amanda Camins Espuny, Antonio Espina, Marta Garcia, Maria Luisa Sánchez-López, Elena |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Souto, Eliana B. Dias-Ferreira, João López-Machado, Ana Ettcheto, Miren Cano, Amanda Camins Espuny, Antonio Espina, Marta Garcia, Maria Luisa Sánchez-López, Elena |
dc.subject.por.fl_str_mv |
ocular drug delivery patents bioavailability anterior eye segment posterior eye segment targeted drug delivery Science & Technology |
topic |
ocular drug delivery patents bioavailability anterior eye segment posterior eye segment targeted drug delivery Science & Technology |
description |
The eye presents extensive perspectives and challenges for drug delivery, mainly because of the extraordinary capacity, intrinsic to this path, for drugs to permeate into the main circulatory system and also for the restrictions of the ocular barriers. Depending on the target segment of the eye, anterior or posterior, the specifications are different. The ocular route experienced in the last decades a lot of progresses related with the development of new drugs, improved formulations, specific-designed delivery and even new routes to administer a drug. Concomitantly, new categories of materials were developed and adapted to encapsulate drugs. With such advances, a multiplicity of parameters became possible to be optimized as the increase in bioavailability and decreased toxic effects of medicines. Also, the formulations were capable to easily adhere to specific tissues, increase the duration of the therapeutic effect and even target the delivery of the treatment. The ascending of new delivery systems for ocular targeting is a current focus, mainly because of the capacity to extend the normal time during which the drug exerts its therapeutic effect and, so, supplying the patients with a product which gives them fewer side effects, fewer number of applications and even more effective outcomes to their pathologies, surpassing the traditionally-used eye drops. Depending on the systems, some are capable of increasing the duration of the drug action as gels, emulsions, prodrugs, liposomes, and ocular inserts with hydrophilic properties, improving the absorption by the cornea. In parallel, other devices use as a strategy the capacity to sustain the release of the carried drugs by means of erodible and non-erodible matrices. This review discusses the different types of advanced formulations used for ocular delivery of therapeutics presenting the most recent patents according to the clinical applications. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/61376 |
url |
http://hdl.handle.net/1822/61376 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Souto, Eliana; Dias-Ferreira, João; López-Machado, Ana; Ettcheto, Miren; Cano, Amanda; Camins Espuny, Antonio; Espina, Marta; Garcia, Maria Luisa; Sánchez-López, Elena, Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents. Pharmaceutics, 11(9), 460, 2019 1999-4923 10.3390/pharmaceutics11090460 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132528496345088 |