Lipid nanoparticles for the posterior eye segment

Detalhes bibliográficos
Autor(a) principal: Bonilla, Lorena
Data de Publicação: 2022
Outros Autores: Espina, Marta, Severino, Patricia, Cano, Amanda, Ettcheto, Miren, Camins, Antoni, García, Maria Luisa, Souto, Eliana B., Sánchez-López, Elena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/75320
Resumo: This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles will also be reviewed. Lipid nanoparticles used as carriers to deliver drugs to the posterior eye segment as well as their administration routes, pharmaceutical forms and ocular distribution will be discussed emphasizing the different targeting strategies most recently employed for ocular drug delivery.
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spelling Lipid nanoparticles for the posterior eye segmentOcular drug deliveryOcular barriersLipid nanoparticlesPosterior segmentDrug transportNLCSLNScience & TechnologyThis review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles will also be reviewed. Lipid nanoparticles used as carriers to deliver drugs to the posterior eye segment as well as their administration routes, pharmaceutical forms and ocular distribution will be discussed emphasizing the different targeting strategies most recently employed for ocular drug delivery.This research was funded by the Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE), under the project reference UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoBonilla, LorenaEspina, MartaSeverino, PatriciaCano, AmandaEttcheto, MirenCamins, AntoniGarcía, Maria LuisaSouto, Eliana B.Sánchez-López, Elena20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/75320engBonilla, Lorena; Espina, Marta; Severino, Patricia; Cano, Amanda; Ettcheto, Miren; Camins, Antoni; García, Maria Luisa; Souto, Eliana B.; Sánchez-López, Elena, Lipid nanoparticles for the posterior eye segment. Pharmaceutics, 14(1), 90, 20221999-492310.3390/pharmaceutics14010090https://www.mdpi.com/1999-4923/14/1/90info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:07:22Zoai:repositorium.sdum.uminho.pt:1822/75320Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:58:19.754751Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Lipid nanoparticles for the posterior eye segment
title Lipid nanoparticles for the posterior eye segment
spellingShingle Lipid nanoparticles for the posterior eye segment
Bonilla, Lorena
Ocular drug delivery
Ocular barriers
Lipid nanoparticles
Posterior segment
Drug transport
NLC
SLN
Science & Technology
title_short Lipid nanoparticles for the posterior eye segment
title_full Lipid nanoparticles for the posterior eye segment
title_fullStr Lipid nanoparticles for the posterior eye segment
title_full_unstemmed Lipid nanoparticles for the posterior eye segment
title_sort Lipid nanoparticles for the posterior eye segment
author Bonilla, Lorena
author_facet Bonilla, Lorena
Espina, Marta
Severino, Patricia
Cano, Amanda
Ettcheto, Miren
Camins, Antoni
García, Maria Luisa
Souto, Eliana B.
Sánchez-López, Elena
author_role author
author2 Espina, Marta
Severino, Patricia
Cano, Amanda
Ettcheto, Miren
Camins, Antoni
García, Maria Luisa
Souto, Eliana B.
Sánchez-López, Elena
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Bonilla, Lorena
Espina, Marta
Severino, Patricia
Cano, Amanda
Ettcheto, Miren
Camins, Antoni
García, Maria Luisa
Souto, Eliana B.
Sánchez-López, Elena
dc.subject.por.fl_str_mv Ocular drug delivery
Ocular barriers
Lipid nanoparticles
Posterior segment
Drug transport
NLC
SLN
Science & Technology
topic Ocular drug delivery
Ocular barriers
Lipid nanoparticles
Posterior segment
Drug transport
NLC
SLN
Science & Technology
description This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles will also be reviewed. Lipid nanoparticles used as carriers to deliver drugs to the posterior eye segment as well as their administration routes, pharmaceutical forms and ocular distribution will be discussed emphasizing the different targeting strategies most recently employed for ocular drug delivery.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/75320
url https://hdl.handle.net/1822/75320
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bonilla, Lorena; Espina, Marta; Severino, Patricia; Cano, Amanda; Ettcheto, Miren; Camins, Antoni; García, Maria Luisa; Souto, Eliana B.; Sánchez-López, Elena, Lipid nanoparticles for the posterior eye segment. Pharmaceutics, 14(1), 90, 2022
1999-4923
10.3390/pharmaceutics14010090
https://www.mdpi.com/1999-4923/14/1/90
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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