Complex Congenital Heart Disease: The Influence of Prenatal Diagnosis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753 |
Resumo: | Introduction: Complex congenital heart disease is a group of severe conditions. Prenatal diagnosis has implications on morbidity and mortality for most severe conditions. The purpose of this work was to evaluate the influence of prenatal diagnosis and distance of residence and birth place to a reference center, on immediate morbidity and early mortality of complex congenital heart disease.Material and Methods:: Retrospective study of complex congenital heart disease patients of our Hospital, born between 2007 and 2012.Results:: There were 126 patients born with complex congenital heart disease. In 95%, pregnancy was followed since the first trimester, with prenatal diagnosis in 42%. There was a statistically significant relation between birth place and prenatal diagnosis. Transposition of great arteries was the most frequent complex congenital heart disease (45.2%), followed by pulmonary atresia with ventricular septal defect (17.5%) and hypoplastic left ventricle (9.5%). Eighty-two patients (65.1%) had prostaglandin infusion and 38 (30.2%)were ventilated before an intervention. Surgery took place in the neonatal period in 73%. Actuarial survival rate at 30 days, 12 and 24 months was 85%, 80% and 75%, respectively. There was no statistically significant relation between prenatal diagnosis and mortality.Discussion:: Most patients with complex congenital heart disease did not have prenatal diagnosis. All cases with prenatal diagnosis were born in a tertiary center. Prenatal diagnosis did not influence significantly neonatal mortality, as already described in other studies with heterogeneous complex heart disease.Conclusion:: prenatal diagnosis of complex congenital heart disease allowed an adequate referral. Most patients with complex congenital heart disease weren’t diagnosed prenatally. This data should be considered when planning prenatal diagnosis of congenital heart disease. |
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Complex Congenital Heart Disease: The Influence of Prenatal DiagnosisCardiopatias Congénitas Complexas: Influência do Diagnóstico Pré-NatalHeart DefectsCongenitalPrenatal Diagnosis.Cardiopatias CongénitasDiagnóstico Pré-natal.Introduction: Complex congenital heart disease is a group of severe conditions. Prenatal diagnosis has implications on morbidity and mortality for most severe conditions. The purpose of this work was to evaluate the influence of prenatal diagnosis and distance of residence and birth place to a reference center, on immediate morbidity and early mortality of complex congenital heart disease.Material and Methods:: Retrospective study of complex congenital heart disease patients of our Hospital, born between 2007 and 2012.Results:: There were 126 patients born with complex congenital heart disease. In 95%, pregnancy was followed since the first trimester, with prenatal diagnosis in 42%. There was a statistically significant relation between birth place and prenatal diagnosis. Transposition of great arteries was the most frequent complex congenital heart disease (45.2%), followed by pulmonary atresia with ventricular septal defect (17.5%) and hypoplastic left ventricle (9.5%). Eighty-two patients (65.1%) had prostaglandin infusion and 38 (30.2%)were ventilated before an intervention. Surgery took place in the neonatal period in 73%. Actuarial survival rate at 30 days, 12 and 24 months was 85%, 80% and 75%, respectively. There was no statistically significant relation between prenatal diagnosis and mortality.Discussion:: Most patients with complex congenital heart disease did not have prenatal diagnosis. All cases with prenatal diagnosis were born in a tertiary center. Prenatal diagnosis did not influence significantly neonatal mortality, as already described in other studies with heterogeneous complex heart disease.Conclusion:: prenatal diagnosis of complex congenital heart disease allowed an adequate referral. Most patients with complex congenital heart disease weren’t diagnosed prenatally. This data should be considered when planning prenatal diagnosis of congenital heart disease.Introdução: As cardiopatias congénitas complexas são patologias graves, e o diagnóstico pré-natal poderá ter implicações sobre a morbilidade e a mortalidade. O objetivo deste trabalho foi estudar a influência do diagnóstico pré-natal e da distância do local de parto a um centro de referência, na morbilidade imediata e mortalidade precoce de um grupo de doentes com cardiopatias congénitas complexas.Material e Métodos: Análise retrospetiva dos doentes com cardiopatias congénitas complexas, seguidos no nosso hospital, nascidos entre 2007 e 2012.Resultados: Identificaram-se 126 doentes com cardiopatias congénitas complexas. Em 95% a gravidez foi vigiada desde o primeiro trimestre existindo diagnóstico pré-natal em 42%. Houve relação estatisticamente significativa entre o local do parto e a existência de diagnóstico pré-natal. A cardiopatia congénita complexa mais frequente foi a transposição das grandes artérias (45,2%), seguida da atresia da pulmonar com comunicação interventricular (17,5%) e ventrículo esquerdo hipoplásico (9,5%). Oitenta e dois doentes (65,1%) foram medicados com prostaglandinas e 38 (30,2%) foram ventilados antes de uma intervenção. A cirurgia ocorreu no período neonatal em 73%. A sobrevida atuarial aos 30 dias, 12 e 24 meses foi 85%, 80% e 75%, respetivamente. Não houve relação estatisticamente significativa entre diagnóstico pré-natal e mortalidade.Discussão: A maioria dos doentes com cardiopatias congénitas complexas não teve diagnóstico pré-natal. Nos casos com diagnóstico pré-natal houve referenciação e parto num centro terciário. Não houve associação estatisticamente significativa entre diagnóstico prénatal e mortalidade neonatal, como já descrito em séries heterogéneas de cardiopatia congénita complexa.Conclusão: A maioria dos doentes com cardiopatias congénitas complexas não teve diagnóstico pré-natal. Estes dados devem ser tomados em conta no planeamento do diagnóstico pré-natal das cardiopatias congénitas.Ordem dos Médicos2015-04-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753oai:ojs.www.actamedicaportuguesa.com:article/5753Acta Médica Portuguesa; Vol. 28 No. 2 (2015): March-April; 158-163Acta Médica Portuguesa; Vol. 28 N.º 2 (2015): Março-Abril; 158-1631646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753/4292https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753/4439https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753/7541Correia, MartaFortunato, FabianaMartins, DuarteTeixeira, AnaNogueira, GraçaMenezes, IsabelAnjos, Ruiinfo:eu-repo/semantics/openAccess2022-12-20T11:04:28Zoai:ojs.www.actamedicaportuguesa.com:article/5753Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:09.468947Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Complex Congenital Heart Disease: The Influence of Prenatal Diagnosis Cardiopatias Congénitas Complexas: Influência do Diagnóstico Pré-Natal |
title |
Complex Congenital Heart Disease: The Influence of Prenatal Diagnosis |
spellingShingle |
Complex Congenital Heart Disease: The Influence of Prenatal Diagnosis Correia, Marta Heart Defects Congenital Prenatal Diagnosis. Cardiopatias Congénitas Diagnóstico Pré-natal. |
title_short |
Complex Congenital Heart Disease: The Influence of Prenatal Diagnosis |
title_full |
Complex Congenital Heart Disease: The Influence of Prenatal Diagnosis |
title_fullStr |
Complex Congenital Heart Disease: The Influence of Prenatal Diagnosis |
title_full_unstemmed |
Complex Congenital Heart Disease: The Influence of Prenatal Diagnosis |
title_sort |
Complex Congenital Heart Disease: The Influence of Prenatal Diagnosis |
author |
Correia, Marta |
author_facet |
Correia, Marta Fortunato, Fabiana Martins, Duarte Teixeira, Ana Nogueira, Graça Menezes, Isabel Anjos, Rui |
author_role |
author |
author2 |
Fortunato, Fabiana Martins, Duarte Teixeira, Ana Nogueira, Graça Menezes, Isabel Anjos, Rui |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Correia, Marta Fortunato, Fabiana Martins, Duarte Teixeira, Ana Nogueira, Graça Menezes, Isabel Anjos, Rui |
dc.subject.por.fl_str_mv |
Heart Defects Congenital Prenatal Diagnosis. Cardiopatias Congénitas Diagnóstico Pré-natal. |
topic |
Heart Defects Congenital Prenatal Diagnosis. Cardiopatias Congénitas Diagnóstico Pré-natal. |
description |
Introduction: Complex congenital heart disease is a group of severe conditions. Prenatal diagnosis has implications on morbidity and mortality for most severe conditions. The purpose of this work was to evaluate the influence of prenatal diagnosis and distance of residence and birth place to a reference center, on immediate morbidity and early mortality of complex congenital heart disease.Material and Methods:: Retrospective study of complex congenital heart disease patients of our Hospital, born between 2007 and 2012.Results:: There were 126 patients born with complex congenital heart disease. In 95%, pregnancy was followed since the first trimester, with prenatal diagnosis in 42%. There was a statistically significant relation between birth place and prenatal diagnosis. Transposition of great arteries was the most frequent complex congenital heart disease (45.2%), followed by pulmonary atresia with ventricular septal defect (17.5%) and hypoplastic left ventricle (9.5%). Eighty-two patients (65.1%) had prostaglandin infusion and 38 (30.2%)were ventilated before an intervention. Surgery took place in the neonatal period in 73%. Actuarial survival rate at 30 days, 12 and 24 months was 85%, 80% and 75%, respectively. There was no statistically significant relation between prenatal diagnosis and mortality.Discussion:: Most patients with complex congenital heart disease did not have prenatal diagnosis. All cases with prenatal diagnosis were born in a tertiary center. Prenatal diagnosis did not influence significantly neonatal mortality, as already described in other studies with heterogeneous complex heart disease.Conclusion:: prenatal diagnosis of complex congenital heart disease allowed an adequate referral. Most patients with complex congenital heart disease weren’t diagnosed prenatally. This data should be considered when planning prenatal diagnosis of congenital heart disease. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753 oai:ojs.www.actamedicaportuguesa.com:article/5753 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753 |
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oai:ojs.www.actamedicaportuguesa.com:article/5753 |
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por eng |
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por eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753/4292 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753/4439 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5753/7541 |
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openAccess |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 28 No. 2 (2015): March-April; 158-163 Acta Médica Portuguesa; Vol. 28 N.º 2 (2015): Março-Abril; 158-163 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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