Polyphenols journey through blood-brain barrier towards neuronal protection

Detalhes bibliográficos
Autor(a) principal: Figueira, I.
Data de Publicação: 2017
Outros Autores: Garcia, G., Pimpão, R., Terrasso, C., Costa, I., Almeida, A., Tavares, L., Pais, T., Pinto, Paula, Ventura, M., Filipe, A., McDougall, G., Stewart, D:, Kim, S., Palmela, I., Brites, D., Brito, M., Santos, C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.15/2222
Resumo: Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to infuence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for diferential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and infammatory injuries and this attenuation of neuroinfammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated infammation and exert neuroprotective efects, with potential for alleviation of neurodegenerative diseases.
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spelling Polyphenols journey through blood-brain barrier towards neuronal protectionComposto fenólicoAge-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to infuence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for diferential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and infammatory injuries and this attenuation of neuroinfammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated infammation and exert neuroprotective efects, with potential for alleviation of neurodegenerative diseases.Nature Publishing GroupRepositório Científico do Instituto Politécnico de SantarémFigueira, I.Garcia, G.Pimpão, R.Terrasso, C.Costa, I.Almeida, A.Tavares, L.Pais, T.Pinto, PaulaVentura, M.Filipe, A.McDougall, G.Stewart, D:Kim, S.Palmela, I.Brites, D.Brito, M.Santos, C.2018-05-22T16:44:10Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.15/2222engFigueira, I.; Garcia, G.; Pimpao, R.C.; Terrasso, A.P.; Costa, I.; Almeida, A. F.; Tavares, L.; Pais, T. F.; Pinto, P.;Ventura, M. R.; Filipe, A.; McDougall, G. J.; Stewart, D.; Kim, S.; Palmela, I.; Brites, D.; Brito, M. A.; Brito, C. and Santos, C. N.(2017). Polyphenols journey through blood-brain barrier towards neuronal protection. Scientific reports, 7: 114562045-232210.1038/s41598-017-11512-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-21T07:32:58Zoai:repositorio.ipsantarem.pt:10400.15/2222Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:54:20.363891Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polyphenols journey through blood-brain barrier towards neuronal protection
title Polyphenols journey through blood-brain barrier towards neuronal protection
spellingShingle Polyphenols journey through blood-brain barrier towards neuronal protection
Figueira, I.
Composto fenólico
title_short Polyphenols journey through blood-brain barrier towards neuronal protection
title_full Polyphenols journey through blood-brain barrier towards neuronal protection
title_fullStr Polyphenols journey through blood-brain barrier towards neuronal protection
title_full_unstemmed Polyphenols journey through blood-brain barrier towards neuronal protection
title_sort Polyphenols journey through blood-brain barrier towards neuronal protection
author Figueira, I.
author_facet Figueira, I.
Garcia, G.
Pimpão, R.
Terrasso, C.
Costa, I.
Almeida, A.
Tavares, L.
Pais, T.
Pinto, Paula
Ventura, M.
Filipe, A.
McDougall, G.
Stewart, D:
Kim, S.
Palmela, I.
Brites, D.
Brito, M.
Santos, C.
author_role author
author2 Garcia, G.
Pimpão, R.
Terrasso, C.
Costa, I.
Almeida, A.
Tavares, L.
Pais, T.
Pinto, Paula
Ventura, M.
Filipe, A.
McDougall, G.
Stewart, D:
Kim, S.
Palmela, I.
Brites, D.
Brito, M.
Santos, C.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico de Santarém
dc.contributor.author.fl_str_mv Figueira, I.
Garcia, G.
Pimpão, R.
Terrasso, C.
Costa, I.
Almeida, A.
Tavares, L.
Pais, T.
Pinto, Paula
Ventura, M.
Filipe, A.
McDougall, G.
Stewart, D:
Kim, S.
Palmela, I.
Brites, D.
Brito, M.
Santos, C.
dc.subject.por.fl_str_mv Composto fenólico
topic Composto fenólico
description Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to infuence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for diferential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and infammatory injuries and this attenuation of neuroinfammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated infammation and exert neuroprotective efects, with potential for alleviation of neurodegenerative diseases.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2018-05-22T16:44:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.15/2222
url http://hdl.handle.net/10400.15/2222
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Figueira, I.; Garcia, G.; Pimpao, R.C.; Terrasso, A.P.; Costa, I.; Almeida, A. F.; Tavares, L.; Pais, T. F.; Pinto, P.;Ventura, M. R.; Filipe, A.; McDougall, G. J.; Stewart, D.; Kim, S.; Palmela, I.; Brites, D.; Brito, M. A.; Brito, C. and Santos, C. N.(2017). Polyphenols journey through blood-brain barrier towards neuronal protection. Scientific reports, 7: 11456
2045-2322
10.1038/s41598-017-11512-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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