Polyphenols journey through blood-brain barrier towards neuronal protection
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.15/2222 |
Resumo: | Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to infuence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for diferential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and infammatory injuries and this attenuation of neuroinfammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated infammation and exert neuroprotective efects, with potential for alleviation of neurodegenerative diseases. |
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Polyphenols journey through blood-brain barrier towards neuronal protectionComposto fenólicoAge-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to infuence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for diferential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and infammatory injuries and this attenuation of neuroinfammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated infammation and exert neuroprotective efects, with potential for alleviation of neurodegenerative diseases.Nature Publishing GroupRepositório Científico do Instituto Politécnico de SantarémFigueira, I.Garcia, G.Pimpão, R.Terrasso, C.Costa, I.Almeida, A.Tavares, L.Pais, T.Pinto, PaulaVentura, M.Filipe, A.McDougall, G.Stewart, D:Kim, S.Palmela, I.Brites, D.Brito, M.Santos, C.2018-05-22T16:44:10Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.15/2222engFigueira, I.; Garcia, G.; Pimpao, R.C.; Terrasso, A.P.; Costa, I.; Almeida, A. F.; Tavares, L.; Pais, T. F.; Pinto, P.;Ventura, M. R.; Filipe, A.; McDougall, G. J.; Stewart, D.; Kim, S.; Palmela, I.; Brites, D.; Brito, M. A.; Brito, C. and Santos, C. N.(2017). Polyphenols journey through blood-brain barrier towards neuronal protection. Scientific reports, 7: 114562045-232210.1038/s41598-017-11512-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-21T07:32:58Zoai:repositorio.ipsantarem.pt:10400.15/2222Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:54:20.363891Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Polyphenols journey through blood-brain barrier towards neuronal protection |
title |
Polyphenols journey through blood-brain barrier towards neuronal protection |
spellingShingle |
Polyphenols journey through blood-brain barrier towards neuronal protection Figueira, I. Composto fenólico |
title_short |
Polyphenols journey through blood-brain barrier towards neuronal protection |
title_full |
Polyphenols journey through blood-brain barrier towards neuronal protection |
title_fullStr |
Polyphenols journey through blood-brain barrier towards neuronal protection |
title_full_unstemmed |
Polyphenols journey through blood-brain barrier towards neuronal protection |
title_sort |
Polyphenols journey through blood-brain barrier towards neuronal protection |
author |
Figueira, I. |
author_facet |
Figueira, I. Garcia, G. Pimpão, R. Terrasso, C. Costa, I. Almeida, A. Tavares, L. Pais, T. Pinto, Paula Ventura, M. Filipe, A. McDougall, G. Stewart, D: Kim, S. Palmela, I. Brites, D. Brito, M. Santos, C. |
author_role |
author |
author2 |
Garcia, G. Pimpão, R. Terrasso, C. Costa, I. Almeida, A. Tavares, L. Pais, T. Pinto, Paula Ventura, M. Filipe, A. McDougall, G. Stewart, D: Kim, S. Palmela, I. Brites, D. Brito, M. Santos, C. |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico de Santarém |
dc.contributor.author.fl_str_mv |
Figueira, I. Garcia, G. Pimpão, R. Terrasso, C. Costa, I. Almeida, A. Tavares, L. Pais, T. Pinto, Paula Ventura, M. Filipe, A. McDougall, G. Stewart, D: Kim, S. Palmela, I. Brites, D. Brito, M. Santos, C. |
dc.subject.por.fl_str_mv |
Composto fenólico |
topic |
Composto fenólico |
description |
Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to infuence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for diferential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and infammatory injuries and this attenuation of neuroinfammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated infammation and exert neuroprotective efects, with potential for alleviation of neurodegenerative diseases. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2018-05-22T16:44:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.15/2222 |
url |
http://hdl.handle.net/10400.15/2222 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Figueira, I.; Garcia, G.; Pimpao, R.C.; Terrasso, A.P.; Costa, I.; Almeida, A. F.; Tavares, L.; Pais, T. F.; Pinto, P.;Ventura, M. R.; Filipe, A.; McDougall, G. J.; Stewart, D.; Kim, S.; Palmela, I.; Brites, D.; Brito, M. A.; Brito, C. and Santos, C. N.(2017). Polyphenols journey through blood-brain barrier towards neuronal protection. Scientific reports, 7: 11456 2045-2322 10.1038/s41598-017-11512-6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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