Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study

Detalhes bibliográficos
Autor(a) principal: Ferrari, Fiorenza
Data de Publicação: 2019
Outros Autores: Romero-González, Gregorio, Topete, Lilia Rizo, Senzolo, Mara, Lorenzin, Anna, Husain-Syed, Faeq, Puci, Mariangela Valentina, Ferraro, Ottavia Eleonora, Muraro, Eva, Serrano-Soto, Mara, Triviño, Alejandra Molano, Castro, Ana, Xie, Yun, Yang, Bo, De Cal, Massimo, Corradi, Valentina, Brendolan, Alessandra, Scarpa, Marta, Carta, Maria Rosa, Giavarina, Davide, Bonato, Raffaele, Ronco, Claudio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/2446
Resumo: The urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 ([TIMP-2]∙[IGFBP7]) have been introduced to improve risk prediction of severe acute kidney injury (AKI) within 12 hours of measurement. We performed a prospective cohort study to evaluate if the predictive value of [TIMP-2]∙[IGFBP7] for AKI might continue after 12 hours. We enrolled 442 critically ill adult patients from June to December 2016. Urine samples were collected at admission for [TIMP-2]∙[IGFBP7] measurement. Baseline patient characteristics were recorded including patients' demographics, prior health history, and the main reason for admission to build a logistic regression model to predict AKI. AKI occurrence differed between patients with [TIMP-2]∙[IGFBP7] ≤0.3 and >0.3 (ng/ml)2/1000 (31.9% and 68.10% respectively; p < 0.001). Patients with AKI had higher biomarker values compared to those without AKI (0.66 (0.21-2.84) vs 0.22 (0.08-0.63) (ng/ml)2/1000; p < 0.001). [TIMP-2]∙[IGFBP7] at ICU admission had a lower performance in predicting AKI at any stage within 48 hours and 7 days after measurement (area under the receiver operating characteristic curve (AUC) equal to 0.70 (95%CI 0.65-0.76), AUC 0.68 (95%CI 0.63-0.73)). In the logistic regression model, 0.1 (ng/ml)2/1000-unit increment was likely to increase the risk of AKI by 2% (p = 0.002).
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spelling Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort StudyThe urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 ([TIMP-2]∙[IGFBP7]) have been introduced to improve risk prediction of severe acute kidney injury (AKI) within 12 hours of measurement. We performed a prospective cohort study to evaluate if the predictive value of [TIMP-2]∙[IGFBP7] for AKI might continue after 12 hours. We enrolled 442 critically ill adult patients from June to December 2016. Urine samples were collected at admission for [TIMP-2]∙[IGFBP7] measurement. Baseline patient characteristics were recorded including patients' demographics, prior health history, and the main reason for admission to build a logistic regression model to predict AKI. AKI occurrence differed between patients with [TIMP-2]∙[IGFBP7] ≤0.3 and >0.3 (ng/ml)2/1000 (31.9% and 68.10% respectively; p < 0.001). Patients with AKI had higher biomarker values compared to those without AKI (0.66 (0.21-2.84) vs 0.22 (0.08-0.63) (ng/ml)2/1000; p < 0.001). [TIMP-2]∙[IGFBP7] at ICU admission had a lower performance in predicting AKI at any stage within 48 hours and 7 days after measurement (area under the receiver operating characteristic curve (AUC) equal to 0.70 (95%CI 0.65-0.76), AUC 0.68 (95%CI 0.63-0.73)). In the logistic regression model, 0.1 (ng/ml)2/1000-unit increment was likely to increase the risk of AKI by 2% (p = 0.002).Nature ResearchRepositório Científico da Unidade Local de Saúde de Santo AntónioFerrari, FiorenzaRomero-González, GregorioTopete, Lilia RizoSenzolo, MaraLorenzin, AnnaHusain-Syed, FaeqPuci, Mariangela ValentinaFerraro, Ottavia EleonoraMuraro, EvaSerrano-Soto, MaraTriviño, Alejandra MolanoCastro, AnaXie, YunYang, BoDe Cal, MassimoCorradi, ValentinaBrendolan, AlessandraScarpa, MartaCarta, Maria RosaGiavarina, DavideBonato, RaffaeleRonco, Claudio2020-08-24T11:42:05Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2446eng2045-232210.1038/s41598-019-52790-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T04:43:45Zoai:repositorio.chporto.pt:10400.16/2446Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T04:43:45Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
title Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
spellingShingle Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
Ferrari, Fiorenza
title_short Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
title_full Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
title_fullStr Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
title_full_unstemmed Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
title_sort Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
author Ferrari, Fiorenza
author_facet Ferrari, Fiorenza
Romero-González, Gregorio
Topete, Lilia Rizo
Senzolo, Mara
Lorenzin, Anna
Husain-Syed, Faeq
Puci, Mariangela Valentina
Ferraro, Ottavia Eleonora
Muraro, Eva
Serrano-Soto, Mara
Triviño, Alejandra Molano
Castro, Ana
Xie, Yun
Yang, Bo
De Cal, Massimo
Corradi, Valentina
Brendolan, Alessandra
Scarpa, Marta
Carta, Maria Rosa
Giavarina, Davide
Bonato, Raffaele
Ronco, Claudio
author_role author
author2 Romero-González, Gregorio
Topete, Lilia Rizo
Senzolo, Mara
Lorenzin, Anna
Husain-Syed, Faeq
Puci, Mariangela Valentina
Ferraro, Ottavia Eleonora
Muraro, Eva
Serrano-Soto, Mara
Triviño, Alejandra Molano
Castro, Ana
Xie, Yun
Yang, Bo
De Cal, Massimo
Corradi, Valentina
Brendolan, Alessandra
Scarpa, Marta
Carta, Maria Rosa
Giavarina, Davide
Bonato, Raffaele
Ronco, Claudio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico da Unidade Local de Saúde de Santo António
dc.contributor.author.fl_str_mv Ferrari, Fiorenza
Romero-González, Gregorio
Topete, Lilia Rizo
Senzolo, Mara
Lorenzin, Anna
Husain-Syed, Faeq
Puci, Mariangela Valentina
Ferraro, Ottavia Eleonora
Muraro, Eva
Serrano-Soto, Mara
Triviño, Alejandra Molano
Castro, Ana
Xie, Yun
Yang, Bo
De Cal, Massimo
Corradi, Valentina
Brendolan, Alessandra
Scarpa, Marta
Carta, Maria Rosa
Giavarina, Davide
Bonato, Raffaele
Ronco, Claudio
description The urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 ([TIMP-2]∙[IGFBP7]) have been introduced to improve risk prediction of severe acute kidney injury (AKI) within 12 hours of measurement. We performed a prospective cohort study to evaluate if the predictive value of [TIMP-2]∙[IGFBP7] for AKI might continue after 12 hours. We enrolled 442 critically ill adult patients from June to December 2016. Urine samples were collected at admission for [TIMP-2]∙[IGFBP7] measurement. Baseline patient characteristics were recorded including patients' demographics, prior health history, and the main reason for admission to build a logistic regression model to predict AKI. AKI occurrence differed between patients with [TIMP-2]∙[IGFBP7] ≤0.3 and >0.3 (ng/ml)2/1000 (31.9% and 68.10% respectively; p < 0.001). Patients with AKI had higher biomarker values compared to those without AKI (0.66 (0.21-2.84) vs 0.22 (0.08-0.63) (ng/ml)2/1000; p < 0.001). [TIMP-2]∙[IGFBP7] at ICU admission had a lower performance in predicting AKI at any stage within 48 hours and 7 days after measurement (area under the receiver operating characteristic curve (AUC) equal to 0.70 (95%CI 0.65-0.76), AUC 0.68 (95%CI 0.63-0.73)). In the logistic regression model, 0.1 (ng/ml)2/1000-unit increment was likely to increase the risk of AKI by 2% (p = 0.002).
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-08-24T11:42:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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10.1038/s41598-019-52790-6
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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