Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit

• Autor(a) principal: Ferrari, Fiorenza
• Data de Publicação: 2019
• Outros Autores: Puci, Mariangela Valentina, Ferraro, Ottavia Eleonora, Romero-González, Gregorio, Husain-Syed, Faeq, Rizo-Topete, Lilia, Senzolo, Mara, Lorenzin, Anna, Muraro, Eva, Baracca, Antonio, Serrano-Soto, Mara, Molano Triviño, Alejandra, Castro, Ana, De Cal, Massimo, Corradi, Valentina, Brendolan, Alessandra, Scarpa, Marta, Carta, Maria Rosa, Giavarina, Davide, Bonato, Raffaele, Iotti, Giorgio Antonio, Ronco, Claudio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.16/2439
• topic: Intensive Care Units

AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p<0.001); SOFAcv ≥ 2 (OR 2.23; 95% CI 1.48-3.37; p<0.001); lactate ≥ 2 mmol/L (OR 1.81; 95% CI 1.19-2.74; p = 0.005) and (TIMP-2)•(IGFBP7) ≥ 0.3 (OR 1.65; 95% CI 1.08-2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0-2; 3-4; 5-6; 7-8 and 9-10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.