Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients
| Autor(a) principal: | |
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| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/62280 |
Resumo: | A corrigendum to this article was published on 09 December 2015: https://doi.org/10.1038/ncomms10203. The corrigendum is also available at: http://hdl.handle.net/1822/62281 |
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Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patientsGenome-Wide Association StudyHumansKaplan-Meier EstimateMultiple MyelomaPolymorphism, Single NucleotideChromosomes, Human, Pair 16Ciências Médicas::Ciências da SaúdeScience & TechnologyA corrigendum to this article was published on 09 December 2015: https://doi.org/10.1038/ncomms10203. The corrigendum is also available at: http://hdl.handle.net/1822/62281Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the association in the IMMEnSE cohort including 772 patients, and a University of Utah cohort including 318 patients (rs72773978 P=0.044). Using publicly available data, we find that the minor allele was associated with increased expression of FOPNL and increased expression of FOPNL was associated with higher expression of centrosomal genes and with shorter survival. Polymorphisms at the FOPNL locus are associated with survival among MM patients.This work was supported by the Steve and Nancy Grand Multiple Myeloma Translational Initiative and a grant from Expression Analysis and a grant from the National Cancer Institute (R21CA191896). E.Z. is supported in part by a mid-career award in patient research from the National Cancer Institute (K24169004). Collection of blood samples from Polish patients and controls from Łodz area, and DNA extraction was supported by a grant from Polish Ministry of Science and Higher Education (No. NN402178334).DNA extraction from Danish healthy controls was supported by The Research Fund at Region Sjælland, Denmark. The Utah study was supported by LLS 6067–09, CA152336and CA134674, with data collection made possible, in part, by the Utah Population Database (UPDB) and the Utah Cancer Registry (UCR). Partial support for all data sets within the UPDB is provided by the Huntsman Cancer Institute (HCI) and the HCICancer Center Support grant, P30 CA42014. The UCR is supported in part by NIH contract HHSN261201000026C from the NCI SEER Program with additional support from the Utah State Department of Health and the University of Utah. In Utah, we thank Jathine Wong for support in formatting files and advice on R programming. Several authors (E.Z., N.C., F.C., C.V.) are members of the International Multiple Myeloma Consortium. We are grateful to the leadership and other members of the International Multiple Myeloma Consortium for facilitating this collaborative study.Nature ResearchUniversidade do MinhoZiv, EladDean, EricHu, DongleiMartino, AlessandroSerie, DanielCurtin, KarenCampa, DanieleAftab, BlakeBracci, PaigeBuda, GabrieleZhao, YiCaswell-Jin, JenniferDiasio, RobertDumontet, CharlesDudziński, MarekFejerman, LauraGreenberg, AlexandraHuntsman, ScottJamroziak, KrzysztofJurczyszyn, ArturKumar, ShajiAtanackovic, DjordjeGlenn, MarthaCannon-Albright, Lisa AJones, BrandtLee, AdamMarques, HerlanderMartin, ThomasMartinez-Lopez, JoaquinRajkumar, VincentSainz, JuanVangsted, Annette JuulWątek, MarzenaWolf, JeffreySlager, SusanCamp, Nicola JCanzian, FedericoVachon, Celine20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62280engZiv, E., Dean, E., Hu, D. et al. Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients. Nat Commun 6, 7539 (2015) doi:10.1038/ncomms85392041-17232041-172310.1038/ncomms853926198393info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:50:11Zoai:repositorium.sdum.uminho.pt:1822/62280Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:48:51.082149Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients |
| title |
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients |
| spellingShingle |
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients Ziv, Elad Genome-Wide Association Study Humans Kaplan-Meier Estimate Multiple Myeloma Polymorphism, Single Nucleotide Chromosomes, Human, Pair 16 Ciências Médicas::Ciências da Saúde Science & Technology |
| title_short |
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients |
| title_full |
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients |
| title_fullStr |
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients |
| title_full_unstemmed |
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients |
| title_sort |
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients |
| author |
Ziv, Elad |
| author_facet |
Ziv, Elad Dean, Eric Hu, Donglei Martino, Alessandro Serie, Daniel Curtin, Karen Campa, Daniele Aftab, Blake Bracci, Paige Buda, Gabriele Zhao, Yi Caswell-Jin, Jennifer Diasio, Robert Dumontet, Charles Dudziński, Marek Fejerman, Laura Greenberg, Alexandra Huntsman, Scott Jamroziak, Krzysztof Jurczyszyn, Artur Kumar, Shaji Atanackovic, Djordje Glenn, Martha Cannon-Albright, Lisa A Jones, Brandt Lee, Adam Marques, Herlander Martin, Thomas Martinez-Lopez, Joaquin Rajkumar, Vincent Sainz, Juan Vangsted, Annette Juul Wątek, Marzena Wolf, Jeffrey Slager, Susan Camp, Nicola J Canzian, Federico Vachon, Celine |
| author_role |
author |
| author2 |
Dean, Eric Hu, Donglei Martino, Alessandro Serie, Daniel Curtin, Karen Campa, Daniele Aftab, Blake Bracci, Paige Buda, Gabriele Zhao, Yi Caswell-Jin, Jennifer Diasio, Robert Dumontet, Charles Dudziński, Marek Fejerman, Laura Greenberg, Alexandra Huntsman, Scott Jamroziak, Krzysztof Jurczyszyn, Artur Kumar, Shaji Atanackovic, Djordje Glenn, Martha Cannon-Albright, Lisa A Jones, Brandt Lee, Adam Marques, Herlander Martin, Thomas Martinez-Lopez, Joaquin Rajkumar, Vincent Sainz, Juan Vangsted, Annette Juul Wątek, Marzena Wolf, Jeffrey Slager, Susan Camp, Nicola J Canzian, Federico Vachon, Celine |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Ziv, Elad Dean, Eric Hu, Donglei Martino, Alessandro Serie, Daniel Curtin, Karen Campa, Daniele Aftab, Blake Bracci, Paige Buda, Gabriele Zhao, Yi Caswell-Jin, Jennifer Diasio, Robert Dumontet, Charles Dudziński, Marek Fejerman, Laura Greenberg, Alexandra Huntsman, Scott Jamroziak, Krzysztof Jurczyszyn, Artur Kumar, Shaji Atanackovic, Djordje Glenn, Martha Cannon-Albright, Lisa A Jones, Brandt Lee, Adam Marques, Herlander Martin, Thomas Martinez-Lopez, Joaquin Rajkumar, Vincent Sainz, Juan Vangsted, Annette Juul Wątek, Marzena Wolf, Jeffrey Slager, Susan Camp, Nicola J Canzian, Federico Vachon, Celine |
| dc.subject.por.fl_str_mv |
Genome-Wide Association Study Humans Kaplan-Meier Estimate Multiple Myeloma Polymorphism, Single Nucleotide Chromosomes, Human, Pair 16 Ciências Médicas::Ciências da Saúde Science & Technology |
| topic |
Genome-Wide Association Study Humans Kaplan-Meier Estimate Multiple Myeloma Polymorphism, Single Nucleotide Chromosomes, Human, Pair 16 Ciências Médicas::Ciências da Saúde Science & Technology |
| description |
A corrigendum to this article was published on 09 December 2015: https://doi.org/10.1038/ncomms10203. The corrigendum is also available at: http://hdl.handle.net/1822/62281 |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1822/62280 |
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http://hdl.handle.net/1822/62280 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ziv, E., Dean, E., Hu, D. et al. Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients. Nat Commun 6, 7539 (2015) doi:10.1038/ncomms8539 2041-1723 2041-1723 10.1038/ncomms8539 26198393 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Nature Research |
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Nature Research |
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