Cross-allergy between penicillins and cephalosporins: a paradigm shift

Detalhes bibliográficos
Autor(a) principal: Dias, Liliana
Data de Publicação: 2022
Outros Autores: Neves, Claudia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/2761
Resumo: Allergic reactions to beta-lactam antibiotics are the most common cause of allergic drug reactions. The incorrect diagnosis prevents patients from receiving a highly effective therapy. The potential cross-reactivity between penicillin and cephalosporin has very significant therapeutic implications. Penicillins and cephalosporins share a common beta-lactam ring and side chains. A number of studies indicate that the R1 side chain, rather than the ring itself, is the determining factor for cross-reactivity. Herein is presented a review of the immunologic mechanisms implicated in penicillin and cephalosporin cross-reactivity and a practical approach to the use of cephalosporins in patients allergic to penicillin.
id RCAP_41c768a199753936b11a4d0741c6eb6f
oai_identifier_str oai:repositorio.chporto.pt:10400.16/2761
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Cross-allergy between penicillins and cephalosporins: a paradigm shiftReatividade cruzada entre penicilinas e cefalosporinas: mudança de paradigmacephalosporincross-reactivitypenicillinside chainAllergic reactions to beta-lactam antibiotics are the most common cause of allergic drug reactions. The incorrect diagnosis prevents patients from receiving a highly effective therapy. The potential cross-reactivity between penicillin and cephalosporin has very significant therapeutic implications. Penicillins and cephalosporins share a common beta-lactam ring and side chains. A number of studies indicate that the R1 side chain, rather than the ring itself, is the determining factor for cross-reactivity. Herein is presented a review of the immunologic mechanisms implicated in penicillin and cephalosporin cross-reactivity and a practical approach to the use of cephalosporins in patients allergic to penicillin.Centro Hospitalar Universitário do PortoRepositório Científico do Centro Hospitalar Universitário de Santo AntónioDias, LilianaNeves, Claudia2023-02-02T10:38:46Z2022-032022-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2761engNascer e Crescer - Birth and Growth Medical Journal 2022;31(1):31-37. doi:10.25753/BirthGrowthMJ.v31.i1.20898https://doi.org/10.25753/BirthGrowthMJ.v31.i1.216072183-9417info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:02:22Zoai:repositorio.chporto.pt:10400.16/2761Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:56.697893Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cross-allergy between penicillins and cephalosporins: a paradigm shift
Reatividade cruzada entre penicilinas e cefalosporinas: mudança de paradigma
title Cross-allergy between penicillins and cephalosporins: a paradigm shift
spellingShingle Cross-allergy between penicillins and cephalosporins: a paradigm shift
Dias, Liliana
cephalosporin
cross-reactivity
penicillin
side chain
title_short Cross-allergy between penicillins and cephalosporins: a paradigm shift
title_full Cross-allergy between penicillins and cephalosporins: a paradigm shift
title_fullStr Cross-allergy between penicillins and cephalosporins: a paradigm shift
title_full_unstemmed Cross-allergy between penicillins and cephalosporins: a paradigm shift
title_sort Cross-allergy between penicillins and cephalosporins: a paradigm shift
author Dias, Liliana
author_facet Dias, Liliana
Neves, Claudia
author_role author
author2 Neves, Claudia
author2_role author
dc.contributor.none.fl_str_mv Repositório Científico do Centro Hospitalar Universitário de Santo António
dc.contributor.author.fl_str_mv Dias, Liliana
Neves, Claudia
dc.subject.por.fl_str_mv cephalosporin
cross-reactivity
penicillin
side chain
topic cephalosporin
cross-reactivity
penicillin
side chain
description Allergic reactions to beta-lactam antibiotics are the most common cause of allergic drug reactions. The incorrect diagnosis prevents patients from receiving a highly effective therapy. The potential cross-reactivity between penicillin and cephalosporin has very significant therapeutic implications. Penicillins and cephalosporins share a common beta-lactam ring and side chains. A number of studies indicate that the R1 side chain, rather than the ring itself, is the determining factor for cross-reactivity. Herein is presented a review of the immunologic mechanisms implicated in penicillin and cephalosporin cross-reactivity and a practical approach to the use of cephalosporins in patients allergic to penicillin.
publishDate 2022
dc.date.none.fl_str_mv 2022-03
2022-03-01T00:00:00Z
2023-02-02T10:38:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.16/2761
url http://hdl.handle.net/10400.16/2761
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nascer e Crescer - Birth and Growth Medical Journal 2022;31(1):31-37. doi:10.25753/BirthGrowthMJ.v31.i1.20898
https://doi.org/10.25753/BirthGrowthMJ.v31.i1.21607
2183-9417
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Centro Hospitalar Universitário do Porto
publisher.none.fl_str_mv Centro Hospitalar Universitário do Porto
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133649261559808

Registros relacionados