Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining

Detalhes bibliográficos
Autor(a) principal: Pérez-Pérez, Martín
Data de Publicação: 2017
Outros Autores: Jorge, Paula, Rodríguez, Gael Pérez, Pereira, Maria Olívia, Lourenço, Anália
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/44828
Resumo: Quorum sensing plays a pivotal role in Pseudomonas aeruginosas virulence. This paper reviews experimental results on antimicrobial strategies based on quorum sensing inhibition and discusses current targets in the regulatory network that determines P. aeruginosa biofilm formation and virulence. A bioinformatics framework combining literature mining with information from biomedical ontologies and curated databases was used to create a knowledge network of potential anti-quorum sensing agents for P. aeruginosa. A total of 110 scientific articles, corresponding to 1,004 annotations were so far included in the network and are analysed in this work. Information on the most studied agents, QS targets and methods is detailed. This knowledge network offers a unique view of existing strategies for quorum sensing inhibition and their main regulatory targets and may be used to readily access otherwise scattered information and to help generate new testable hypotheses. This knowledge network is publicly available at http://pcquorum.org/
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spelling Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network miningQuorum-sensingQuorum-quenchingPseudomonas aeruginosaBiofilmBioinformaticsNetworksScience & TechnologyQuorum sensing plays a pivotal role in Pseudomonas aeruginosas virulence. This paper reviews experimental results on antimicrobial strategies based on quorum sensing inhibition and discusses current targets in the regulatory network that determines P. aeruginosa biofilm formation and virulence. A bioinformatics framework combining literature mining with information from biomedical ontologies and curated databases was used to create a knowledge network of potential anti-quorum sensing agents for P. aeruginosa. A total of 110 scientific articles, corresponding to 1,004 annotations were so far included in the network and are analysed in this work. Information on the most studied agents, QS targets and methods is detailed. This knowledge network offers a unique view of existing strategies for quorum sensing inhibition and their main regulatory targets and may be used to readily access otherwise scattered information and to help generate new testable hypotheses. This knowledge network is publicly available at http://pcquorum.org/This work was partially funded by the Research Grant 2014 of Anália Lourenço by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), the INOU16-05 project from the Provincial Council of Ourense, the European Union’s Seventh Framework Programme FP7/ REGPOT-2012-2013.1 [grant agreement number 316265], BIOCAPS, the Portuguese Foundation for Science and Technology (FCT) under the strategic funding of UID/BIO/04469/2013 unit, the FCT and the European Community fund FEDER, through Programme COMPETE, under the scope of the Project RECI/BBB- EBI/0179/2012 [FCOMP-010124-FEDER-027462]. SING group also thanks CITI (Centro de Investigación, Transferencia e Innovación) from University of Vigo for hosting its IT infrastructure. The authors also acknowledge FCT for the PhD Grant to Paula Jorge [grant number SFRH/BD/88192/2012]. M. Pérez-Pérez and G. Pérez Rodríguez were supported by pre-doctoral fellowships from the Xunta de Galicia and the University of Vigo.Taylor and FrancisUniversidade do MinhoPérez-Pérez, MartínJorge, PaulaRodríguez, Gael PérezPereira, Maria OlíviaLourenço, Anália2017-01-252017-01-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/44828engPérez-Pérez, Martín; Jorge, Paula; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, Anália, Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining. Biofouling, 33(2), 128-142, 20170892-70141029-245410.1080/08927014.2016.127210428121162info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:48:59Zoai:repositorium.sdum.uminho.pt:1822/44828Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:47:23.019668Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining
title Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining
spellingShingle Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining
Pérez-Pérez, Martín
Quorum-sensing
Quorum-quenching
Pseudomonas aeruginosa
Biofilm
Bioinformatics
Networks
Science & Technology
title_short Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining
title_full Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining
title_fullStr Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining
title_full_unstemmed Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining
title_sort Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining
author Pérez-Pérez, Martín
author_facet Pérez-Pérez, Martín
Jorge, Paula
Rodríguez, Gael Pérez
Pereira, Maria Olívia
Lourenço, Anália
author_role author
author2 Jorge, Paula
Rodríguez, Gael Pérez
Pereira, Maria Olívia
Lourenço, Anália
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pérez-Pérez, Martín
Jorge, Paula
Rodríguez, Gael Pérez
Pereira, Maria Olívia
Lourenço, Anália
dc.subject.por.fl_str_mv Quorum-sensing
Quorum-quenching
Pseudomonas aeruginosa
Biofilm
Bioinformatics
Networks
Science & Technology
topic Quorum-sensing
Quorum-quenching
Pseudomonas aeruginosa
Biofilm
Bioinformatics
Networks
Science & Technology
description Quorum sensing plays a pivotal role in Pseudomonas aeruginosas virulence. This paper reviews experimental results on antimicrobial strategies based on quorum sensing inhibition and discusses current targets in the regulatory network that determines P. aeruginosa biofilm formation and virulence. A bioinformatics framework combining literature mining with information from biomedical ontologies and curated databases was used to create a knowledge network of potential anti-quorum sensing agents for P. aeruginosa. A total of 110 scientific articles, corresponding to 1,004 annotations were so far included in the network and are analysed in this work. Information on the most studied agents, QS targets and methods is detailed. This knowledge network offers a unique view of existing strategies for quorum sensing inhibition and their main regulatory targets and may be used to readily access otherwise scattered information and to help generate new testable hypotheses. This knowledge network is publicly available at http://pcquorum.org/
publishDate 2017
dc.date.none.fl_str_mv 2017-01-25
2017-01-25T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/44828
url http://hdl.handle.net/1822/44828
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pérez-Pérez, Martín; Jorge, Paula; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, Anália, Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining. Biofouling, 33(2), 128-142, 2017
0892-7014
1029-2454
10.1080/08927014.2016.1272104
28121162
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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