PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation

Detalhes bibliográficos
Autor(a) principal: Campos, Cláudia F.
Data de Publicação: 2019
Outros Autores: Leite, Luís, Pereira, Paulo, Vaz, Carlos Pinho, Branca, Rosa, Campilho, Fernando, Freitas, Fátima, Ligeiro, Dário, Marques, António, Torrado, Egídio, Silvestre, Ricardo, Lacerda, João, Campos Jr., António, Cunha, Cristina, Carvalho, Agostinho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55224
Resumo: Copyright © 2019 Campos, Leite, Pereira, Vaz, Branca, Campilho, Freitas, Ligeiro, Marques, Torrado, Silvestre, Lacerda, Campos, Cunha and Carvalho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantationPTX3CytomegalovirusGenomicsPrecision medicineSingle nucleotide polymorphismStem-cell transplantationCopyright © 2019 Campos, Leite, Pereira, Vaz, Branca, Campilho, Freitas, Ligeiro, Marques, Torrado, Silvestre, Lacerda, Campos, Cunha and Carvalho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Background: Reactivation of latent human cytomegalovirus (CMV) in patients undergoing allogeneic stem-cell transplantation (HSCT) predisposes to several clinical complications and is therefore a major cause of morbidity and mortality. Although pentraxin-3 (PTX3) has been previously described to bind both human and murine CMV and mediate several host antiviral mechanisms, whether genetic variation in the PTX3 locus influences the risk of CMV infection is currently unknown. Methods: To dissect the contribution of genetic variation within PTX3 to the development of CMV infection, we analyzed described loss-of-function variants at the PTX3 locus in 394 recipients of HSCT and their corresponding donors and assessed the associated risk of CMV reactivation. Results: We report that the donor, but not recipient, h2/h2 haplotype in PTX3 increased the risk of CMV reactivation after 24 months following transplantation, with a significant effect on survival. Among recipients with h2/h2 donors, CMV seropositive patients as well as those receiving grafts from unrelated donors, regardless of the CMV serostatus, were more prone to develop viral reactivation after transplantation. Most importantly, the h2/h2 haplotype was demonstrated to display an influence toward risk of CMV reactivation comparable to that conferred by the unrelated status of the donor alone. Conclusions: Our findings demonstrate the important contribution of genetic variation in donor PTX3 to the risk of CMV reactivation in patients undergoing HSCT, highlighting a promising prognostic value of donor PTX3 to predict risk of CMV reactivation in this clinical setting.This work was supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013), and the Fundação para a Ciência e Tecnologia (FCT) (SFRH/BPD/96176/2013 to CC, IF/01390/2014 to ET, IF/00021/2014 to RS, and IF/00735/2014 to AgC).FrontiersRepositório da Universidade de LisboaCampos, Cláudia F.Leite, LuísPereira, PauloVaz, Carlos PinhoBranca, RosaCampilho, FernandoFreitas, FátimaLigeiro, DárioMarques, AntónioTorrado, EgídioSilvestre, RicardoLacerda, JoãoCampos Jr., AntónioCunha, CristinaCarvalho, Agostinho2022-11-23T15:31:03Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55224engFront Immunol. 2019 Jan 31;10:8810.3389/fimmu.2019.000881664-3224info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:02Zoai:repositorio.ul.pt:10451/55224Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:53.099756Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation
title PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation
spellingShingle PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation
Campos, Cláudia F.
PTX3
Cytomegalovirus
Genomics
Precision medicine
Single nucleotide polymorphism
Stem-cell transplantation
title_short PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation
title_full PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation
title_fullStr PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation
title_full_unstemmed PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation
title_sort PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation
author Campos, Cláudia F.
author_facet Campos, Cláudia F.
Leite, Luís
Pereira, Paulo
Vaz, Carlos Pinho
Branca, Rosa
Campilho, Fernando
Freitas, Fátima
Ligeiro, Dário
Marques, António
Torrado, Egídio
Silvestre, Ricardo
Lacerda, João
Campos Jr., António
Cunha, Cristina
Carvalho, Agostinho
author_role author
author2 Leite, Luís
Pereira, Paulo
Vaz, Carlos Pinho
Branca, Rosa
Campilho, Fernando
Freitas, Fátima
Ligeiro, Dário
Marques, António
Torrado, Egídio
Silvestre, Ricardo
Lacerda, João
Campos Jr., António
Cunha, Cristina
Carvalho, Agostinho
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Campos, Cláudia F.
Leite, Luís
Pereira, Paulo
Vaz, Carlos Pinho
Branca, Rosa
Campilho, Fernando
Freitas, Fátima
Ligeiro, Dário
Marques, António
Torrado, Egídio
Silvestre, Ricardo
Lacerda, João
Campos Jr., António
Cunha, Cristina
Carvalho, Agostinho
dc.subject.por.fl_str_mv PTX3
Cytomegalovirus
Genomics
Precision medicine
Single nucleotide polymorphism
Stem-cell transplantation
topic PTX3
Cytomegalovirus
Genomics
Precision medicine
Single nucleotide polymorphism
Stem-cell transplantation
description Copyright © 2019 Campos, Leite, Pereira, Vaz, Branca, Campilho, Freitas, Ligeiro, Marques, Torrado, Silvestre, Lacerda, Campos, Cunha and Carvalho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2022-11-23T15:31:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55224
url http://hdl.handle.net/10451/55224
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Immunol. 2019 Jan 31;10:88
10.3389/fimmu.2019.00088
1664-3224
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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