Glial plasticity in depression
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/49211 |
Resumo: | Copyright © 2016 Oliveira, Gomes, Vaz, Sousa and Pinto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Glial plasticity in depressionAstrocyteDepressionGliaMicrogliaOligodendrocitesCopyright © 2016 Oliveira, Gomes, Vaz, Sousa and Pinto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Depression is a highly prevalent disorder that poses a significant social burden to society. Despite continued advances toward the understanding of the pathophysiology of this disease, its molecular/cellular underpinnings remain elusive, which may be at the basis of the lack of effective treatment strategies. Among the different lines of research, recent literature suggests that impaired neuron and glial plasticity may be a key underlying mechanism in the precipitation of the disorder. Surprisingly, glial cells appear to be involved both in the pathophysiology of major depression and in the action of antidepressants. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia, and oligodendrocytes in the context of depression, in human patients, and animal models of depression. These observations are linked to functional evidences, such as impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, and synapse formation, maintenance or elimination.JO and LP received fellowships from the Foundation for Science and Technology (FCT) and their work is funded by FCT (SFRH/BD/101298/2014 to JO and IF/01079/2014 to LP) and Bial Foundation (207/14 for JO and 427/14 for LP) projects. SV is supported by FCT (SFRH/BPD/81627/2011). CG is supported by FCT (SFRH/BPD/63013/2009). This work was co-funded by the Life and Health Sciences Research Institute (ICVS), and Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (projects NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023). This work has been also funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the (FCT), under the scope of the project POCI-01-0145-FEDER-007038.FrontiersRepositório da Universidade de LisboaOliveira, João F.Gomes, Catarina A.Vaz, Sandra H.Sousa, NunoPinto, Luisa2021-07-29T13:45:58Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49211engFront Cell Neurosci. 2016 Jun 17;10:16310.3389/fncel.2016.001631662-5102info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:42Zoai:repositorio.ul.pt:10451/49211Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:49.866762Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Glial plasticity in depression |
| title |
Glial plasticity in depression |
| spellingShingle |
Glial plasticity in depression Oliveira, João F. Astrocyte Depression Glia Microglia Oligodendrocites |
| title_short |
Glial plasticity in depression |
| title_full |
Glial plasticity in depression |
| title_fullStr |
Glial plasticity in depression |
| title_full_unstemmed |
Glial plasticity in depression |
| title_sort |
Glial plasticity in depression |
| author |
Oliveira, João F. |
| author_facet |
Oliveira, João F. Gomes, Catarina A. Vaz, Sandra H. Sousa, Nuno Pinto, Luisa |
| author_role |
author |
| author2 |
Gomes, Catarina A. Vaz, Sandra H. Sousa, Nuno Pinto, Luisa |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Oliveira, João F. Gomes, Catarina A. Vaz, Sandra H. Sousa, Nuno Pinto, Luisa |
| dc.subject.por.fl_str_mv |
Astrocyte Depression Glia Microglia Oligodendrocites |
| topic |
Astrocyte Depression Glia Microglia Oligodendrocites |
| description |
Copyright © 2016 Oliveira, Gomes, Vaz, Sousa and Pinto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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2016 |
| dc.date.none.fl_str_mv |
2016 2016-01-01T00:00:00Z 2021-07-29T13:45:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/49211 |
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http://hdl.handle.net/10451/49211 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Front Cell Neurosci. 2016 Jun 17;10:163 10.3389/fncel.2016.00163 1662-5102 |
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Frontiers |
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Frontiers |
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