Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunction

Detalhes bibliográficos
Autor(a) principal: Marques, Joao Silva
Data de Publicação: 2012
Outros Autores: Almeida, Ana G., David, Cláudio, Rodrigues, Henrique Luz, Diogo, António
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/34799
Resumo: © 2012 Marques JS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This article was originally published in a special issue, Cardiac Biomarkers handled by Editor(s). Dr. Virginija Jazbutyte, Institute for Molecular and Translational Therapy Strategies, Germany
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spelling Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunctionSystolic heart failureBiological markersCopeptinPrognosis© 2012 Marques JS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This article was originally published in a special issue, Cardiac Biomarkers handled by Editor(s). Dr. Virginija Jazbutyte, Institute for Molecular and Translational Therapy Strategies, GermanyBackground: Patients with heart failure and impaired systolic function may have a highly variable clinical course that renders it difficult to assess the individual prognosis. We hypothesized that ejection fraction would incompletely characterize prognosis in systolic heart failure and that biomarkers would add significant information. This study addresses the specific question whether co-peptin may add value in the evaluation of two-year prognosis in heart failure patients with known systolic dysfunction. Methods: Prospective observational cohort study in 37 patients with symptomatic chronic heart failure (classes II to IV of the NYHA classification) and moderate to severe left ventricular systolic dysfunction. We evaluated clinical, echo-cardiographic and laboratory predictors of 24-month mortality specifically assessing the role of co-peptin. Results: Six patients (16%) died during the follow-up. Patients who died had significant higher prevalence of NYHA class IV heart failure, higher blood osmolality and higher levels of NT-proBNP and co-peptin. In unvariable analysis NYHA functional class (p=0.013), serum creatinine (p=0.034), osmolality (p=0.009), NT-proBNP (p=0.013) and copeptin (p=0.003) were predictors of mortality at 24 months. Only copeptin (p=0.004) remained an independent predictor of death in Cox regression analysis. Conclusions: Our results suggest that, in patients with heart failure and impaired left ventricular systolic function, copeptin level determination may be useful for predicting mortality at two years.The study was funded by Centro de Cardiologia da Universidade de Lisboa (CCUL), Cardiology Centre of Lisbon University.OMICS InternationalRepositório da Universidade de LisboaMarques, Joao SilvaAlmeida, Ana G.David, CláudioRodrigues, Henrique LuzDiogo, António2018-09-13T16:03:58Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/34799engJ Clin Exp Cardiolog S22155-988010.4172/2155-9880.S2-006info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:30:20Zoai:repositorio.ul.pt:10451/34799Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:49:26.137733Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunction
title Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunction
spellingShingle Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunction
Marques, Joao Silva
Systolic heart failure
Biological markers
Copeptin
Prognosis
title_short Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunction
title_full Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunction
title_fullStr Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunction
title_full_unstemmed Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunction
title_sort Copeptin for discriminating two-year mortality in heart failure patients with moderate to severe systolic dysfunction
author Marques, Joao Silva
author_facet Marques, Joao Silva
Almeida, Ana G.
David, Cláudio
Rodrigues, Henrique Luz
Diogo, António
author_role author
author2 Almeida, Ana G.
David, Cláudio
Rodrigues, Henrique Luz
Diogo, António
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Marques, Joao Silva
Almeida, Ana G.
David, Cláudio
Rodrigues, Henrique Luz
Diogo, António
dc.subject.por.fl_str_mv Systolic heart failure
Biological markers
Copeptin
Prognosis
topic Systolic heart failure
Biological markers
Copeptin
Prognosis
description © 2012 Marques JS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This article was originally published in a special issue, Cardiac Biomarkers handled by Editor(s). Dr. Virginija Jazbutyte, Institute for Molecular and Translational Therapy Strategies, Germany
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2018-09-13T16:03:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/34799
url http://hdl.handle.net/10451/34799
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Clin Exp Cardiolog S2
2155-9880
10.4172/2155-9880.S2-006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv OMICS International
publisher.none.fl_str_mv OMICS International
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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