Plasma copeptin and metabolic dysfunction in individuals with bipolar disorder

• Autor(a) principal: Mansur, Rodrigo B. [UNIFESP]
• Data de Publicação: 2017
• Outros Autores: Rizzo, Lucas B. [UNIFESP], Santos, Camila M. [UNIFESP], Asevedo, Elson [UNIFESP], Cunha, Graccielle R. [UNIFESP], Noto, Mariane N. [UNIFESP], Pedrini, Mariana [UNIFESP], Zeni-Graiff, Maiara [UNIFESP], Cordeiro, Quirino, McIntyre, Roger S., Brietzke, Elisa [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1111/pcn.12535; http://repositorio.unifesp.br/handle/11600/51326
• topic: bipolar disorder; copeptin; insulin resistance; metabolism; vasopressin

AimThis study aimed to compare plasma copeptin levels, the c-terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relation between copeptin and metabolic parameters. MethodsWe measured plasma levels of copeptin in individuals with BD (n=55) and healthy controls (n=21). Information related to psychiatric/medical history, as well as to metabolic comorbidities and laboratorial parameters was also captured. Insulin resistance and -cell function in basal state were calculated from fasting plasma glucose and C-peptide using the HOMA2 calculator. Impaired glucose metabolism was defined as pre-diabetes or type 2 diabetes mellitus. Copeptin, adiponectin, and leptin plasma levels were determined by enzyme-linked immunosorbent assay. ResultsPlasma copeptin levels were lower in individuals with BD, relative to healthy controls (P<0.001). There were significant interactions between BD and plasma copeptin on -cell function (rate ratio [RR]=1.048