Changes in components of the brain extracellular matrix after experimental ischemic stroke

Detalhes bibliográficos
Autor(a) principal: Guerreiro, Carla Sofia de Jesus
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/7977
Resumo: Dissertação de mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina , Universidade do Algarve; Laboratory for Experimental Brain Research, Lund University, 2014
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spelling Changes in components of the brain extracellular matrix after experimental ischemic strokeCiências biomédicasAVCEnfarte do miocárdioTromboseTerapiasDomínio/Área Científica::Ciências Médicas::Biotecnologia MédicaDissertação de mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina , Universidade do Algarve; Laboratory for Experimental Brain Research, Lund University, 2014Stroke is the 3rd cause of death in the world. During stroke, there is a disruption in the blood supply to the brain leading to rapid loss of brain function. Ischemic strokes are caused by obstruction of the blood supply, while hemorrhagic strokes results from rupture of a blood vessel. Eight-five percent of the strokes are ischemic. The only treatment recommended for acute ischemic stroke is the recombinant tissue activator of plasminogen but only a few percentages of patients are eligible for rtPA administration. Approximately 30% of the ischemic stroke victims die and 30% become severely disabled, resulting in among others deficits in motor function in the contralateral musculature. Spontaneous recovery occurs during weeks to months following injury. There are many physiological and anatomical examples of cortical brain plasticity and one of the most potent modulators of cortical structure and function is behavioral experience. Functional recovery after stroke can be enhanced by physical training in stroke patients. In the animal settings, physical training can be accomplished by enriched environment (EE). EE refers to housing conditions, either home cages or exploratory chamber, that facilitate enhanced sensory, cognitive and motor stimulation relative to standard housing conditions. The extracellular matrix (ECM) is important in the regulation of brain plasticity but is also a potential hampering factor for recovery after stroke. It is known that EE affects chondroitin sulfate proteoglycans (CSPGs) present in ECM, leading to functional recovery. Matrix metalloproteinases (MMPs) are able to cleave ECM components. There are some evidences that beta-dystroglycan (β-DG) is a MMP-9 target. After the degradation of β-DG, there is a 30 kDa product. The aim of this work is to explore how EE affects β-DG and gelatinases over 1 week of recovery after experimental stroke, performed as photothrombosis (PT). We show that EE does not affect the infarct size and improves tactile/proprioceptive response to limb stimulation. We found that β-DG is mostly present in vessels across the brain cortex and animals housed in an EE had a higher degradation than STD animals when comparing to sham non-operated animals. β-DG can be related with changes in the ECM that leads to brain plasticity, promoting functional recovery after experimental stroke, possibly due to MMPs enzymatic activity.Wieloch, TadeuszAraújo, InêsQuattromani, Miriana JleniaSapientiaGuerreiro, Carla Sofia de Jesus2016-04-12T10:19:08Z201420142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.1/7977TID:202213200enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:19:10Zoai:sapientia.ualg.pt:10400.1/7977Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:00:13.430394Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Changes in components of the brain extracellular matrix after experimental ischemic stroke
title Changes in components of the brain extracellular matrix after experimental ischemic stroke
spellingShingle Changes in components of the brain extracellular matrix after experimental ischemic stroke
Guerreiro, Carla Sofia de Jesus
Ciências biomédicas
AVC
Enfarte do miocárdio
Trombose
Terapias
Domínio/Área Científica::Ciências Médicas::Biotecnologia Médica
title_short Changes in components of the brain extracellular matrix after experimental ischemic stroke
title_full Changes in components of the brain extracellular matrix after experimental ischemic stroke
title_fullStr Changes in components of the brain extracellular matrix after experimental ischemic stroke
title_full_unstemmed Changes in components of the brain extracellular matrix after experimental ischemic stroke
title_sort Changes in components of the brain extracellular matrix after experimental ischemic stroke
author Guerreiro, Carla Sofia de Jesus
author_facet Guerreiro, Carla Sofia de Jesus
author_role author
dc.contributor.none.fl_str_mv Wieloch, Tadeusz
Araújo, Inês
Quattromani, Miriana Jlenia
Sapientia
dc.contributor.author.fl_str_mv Guerreiro, Carla Sofia de Jesus
dc.subject.por.fl_str_mv Ciências biomédicas
AVC
Enfarte do miocárdio
Trombose
Terapias
Domínio/Área Científica::Ciências Médicas::Biotecnologia Médica
topic Ciências biomédicas
AVC
Enfarte do miocárdio
Trombose
Terapias
Domínio/Área Científica::Ciências Médicas::Biotecnologia Médica
description Dissertação de mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina , Universidade do Algarve; Laboratory for Experimental Brain Research, Lund University, 2014
publishDate 2014
dc.date.none.fl_str_mv 2014
2014
2014-01-01T00:00:00Z
2016-04-12T10:19:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/7977
TID:202213200
url http://hdl.handle.net/10400.1/7977
identifier_str_mv TID:202213200
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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