Muller’s ratchet and the pattern of variation at a neutral locus
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/96 |
Resumo: | The levels and patterns of variation at a neutral locus are analyzed in a haploid asexual population Undergoing accumulation of deleterious mutations due to Muller's ratchet. We find that the movement Of Muller's ratchet can be associated with a considerable reduction in genetic diversity below classical neutral expectation. The extent to which variability is reduced is a function Of the deleterious initiation rate, the fitness effects of the Imitations, and the population size. Approximate analytical expressions for the expected genetic diversity are compared with simulation results under two different models of deleterious imitations: a model where all deleterious imitations have equal effects and a model where there are two classes of deleterious imitations. We also find that Muller's ratchet can produce a considerable distortion in the neutral frequency spectrum toward an excess of rare variants. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
spelling |
Muller’s ratchet and the pattern of variation at a neutral locusBACKGROUND SELECTIONASEXUAL POPULATIONSSTATISTICAL TESTSY-CHROMOSOMESDELETERIOUS MUTATIONSDOSAGE COMPENSATIONMOLECULAR EVOLUTIONDNA POLYMORPHISMDEGENERATIONACCUMULATIONThe levels and patterns of variation at a neutral locus are analyzed in a haploid asexual population Undergoing accumulation of deleterious mutations due to Muller's ratchet. We find that the movement Of Muller's ratchet can be associated with a considerable reduction in genetic diversity below classical neutral expectation. The extent to which variability is reduced is a function Of the deleterious initiation rate, the fitness effects of the Imitations, and the population size. Approximate analytical expressions for the expected genetic diversity are compared with simulation results under two different models of deleterious imitations: a model where all deleterious imitations have equal effects and a model where there are two classes of deleterious imitations. We also find that Muller's ratchet can produce a considerable distortion in the neutral frequency spectrum toward an excess of rare variants.ARCAGordo, I.Navarro, A.Charlesworth, B.2010-03-31T08:59:55Z2002-062002-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/96eng0016-6731info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T14:19:58Zoai:arca.igc.gulbenkian.pt:10400.7/96Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T14:19:58Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Muller’s ratchet and the pattern of variation at a neutral locus |
title |
Muller’s ratchet and the pattern of variation at a neutral locus |
spellingShingle |
Muller’s ratchet and the pattern of variation at a neutral locus Gordo, I. BACKGROUND SELECTION ASEXUAL POPULATIONS STATISTICAL TESTS Y-CHROMOSOMES DELETERIOUS MUTATIONS DOSAGE COMPENSATION MOLECULAR EVOLUTION DNA POLYMORPHISM DEGENERATION ACCUMULATION |
title_short |
Muller’s ratchet and the pattern of variation at a neutral locus |
title_full |
Muller’s ratchet and the pattern of variation at a neutral locus |
title_fullStr |
Muller’s ratchet and the pattern of variation at a neutral locus |
title_full_unstemmed |
Muller’s ratchet and the pattern of variation at a neutral locus |
title_sort |
Muller’s ratchet and the pattern of variation at a neutral locus |
author |
Gordo, I. |
author_facet |
Gordo, I. Navarro, A. Charlesworth, B. |
author_role |
author |
author2 |
Navarro, A. Charlesworth, B. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Gordo, I. Navarro, A. Charlesworth, B. |
dc.subject.por.fl_str_mv |
BACKGROUND SELECTION ASEXUAL POPULATIONS STATISTICAL TESTS Y-CHROMOSOMES DELETERIOUS MUTATIONS DOSAGE COMPENSATION MOLECULAR EVOLUTION DNA POLYMORPHISM DEGENERATION ACCUMULATION |
topic |
BACKGROUND SELECTION ASEXUAL POPULATIONS STATISTICAL TESTS Y-CHROMOSOMES DELETERIOUS MUTATIONS DOSAGE COMPENSATION MOLECULAR EVOLUTION DNA POLYMORPHISM DEGENERATION ACCUMULATION |
description |
The levels and patterns of variation at a neutral locus are analyzed in a haploid asexual population Undergoing accumulation of deleterious mutations due to Muller's ratchet. We find that the movement Of Muller's ratchet can be associated with a considerable reduction in genetic diversity below classical neutral expectation. The extent to which variability is reduced is a function Of the deleterious initiation rate, the fitness effects of the Imitations, and the population size. Approximate analytical expressions for the expected genetic diversity are compared with simulation results under two different models of deleterious imitations: a model where all deleterious imitations have equal effects and a model where there are two classes of deleterious imitations. We also find that Muller's ratchet can produce a considerable distortion in the neutral frequency spectrum toward an excess of rare variants. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-06 2002-06-01T00:00:00Z 2010-03-31T08:59:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/96 |
url |
http://hdl.handle.net/10400.7/96 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0016-6731 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817549559842209792 |