Muller’s ratchet and the pattern of variation at a neutral locus

Detalhes bibliográficos
Autor(a) principal: Gordo, I.
Data de Publicação: 2002
Outros Autores: Navarro, A., Charlesworth, B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/96
Resumo: The levels and patterns of variation at a neutral locus are analyzed in a haploid asexual population Undergoing accumulation of deleterious mutations due to Muller's ratchet. We find that the movement Of Muller's ratchet can be associated with a considerable reduction in genetic diversity below classical neutral expectation. The extent to which variability is reduced is a function Of the deleterious initiation rate, the fitness effects of the Imitations, and the population size. Approximate analytical expressions for the expected genetic diversity are compared with simulation results under two different models of deleterious imitations: a model where all deleterious imitations have equal effects and a model where there are two classes of deleterious imitations. We also find that Muller's ratchet can produce a considerable distortion in the neutral frequency spectrum toward an excess of rare variants.
id RCAP_4388c02a9063eac90102e3f2a20cd88f
oai_identifier_str oai:arca.igc.gulbenkian.pt:10400.7/96
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Muller’s ratchet and the pattern of variation at a neutral locusBACKGROUND SELECTIONASEXUAL POPULATIONSSTATISTICAL TESTSY-CHROMOSOMESDELETERIOUS MUTATIONSDOSAGE COMPENSATIONMOLECULAR EVOLUTIONDNA POLYMORPHISMDEGENERATIONACCUMULATIONThe levels and patterns of variation at a neutral locus are analyzed in a haploid asexual population Undergoing accumulation of deleterious mutations due to Muller's ratchet. We find that the movement Of Muller's ratchet can be associated with a considerable reduction in genetic diversity below classical neutral expectation. The extent to which variability is reduced is a function Of the deleterious initiation rate, the fitness effects of the Imitations, and the population size. Approximate analytical expressions for the expected genetic diversity are compared with simulation results under two different models of deleterious imitations: a model where all deleterious imitations have equal effects and a model where there are two classes of deleterious imitations. We also find that Muller's ratchet can produce a considerable distortion in the neutral frequency spectrum toward an excess of rare variants.ARCAGordo, I.Navarro, A.Charlesworth, B.2010-03-31T08:59:55Z2002-062002-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/96eng0016-6731info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T14:19:58Zoai:arca.igc.gulbenkian.pt:10400.7/96Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T14:19:58Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Muller’s ratchet and the pattern of variation at a neutral locus
title Muller’s ratchet and the pattern of variation at a neutral locus
spellingShingle Muller’s ratchet and the pattern of variation at a neutral locus
Gordo, I.
BACKGROUND SELECTION
ASEXUAL POPULATIONS
STATISTICAL TESTS
Y-CHROMOSOMES
DELETERIOUS MUTATIONS
DOSAGE COMPENSATION
MOLECULAR EVOLUTION
DNA POLYMORPHISM
DEGENERATION
ACCUMULATION
title_short Muller’s ratchet and the pattern of variation at a neutral locus
title_full Muller’s ratchet and the pattern of variation at a neutral locus
title_fullStr Muller’s ratchet and the pattern of variation at a neutral locus
title_full_unstemmed Muller’s ratchet and the pattern of variation at a neutral locus
title_sort Muller’s ratchet and the pattern of variation at a neutral locus
author Gordo, I.
author_facet Gordo, I.
Navarro, A.
Charlesworth, B.
author_role author
author2 Navarro, A.
Charlesworth, B.
author2_role author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Gordo, I.
Navarro, A.
Charlesworth, B.
dc.subject.por.fl_str_mv BACKGROUND SELECTION
ASEXUAL POPULATIONS
STATISTICAL TESTS
Y-CHROMOSOMES
DELETERIOUS MUTATIONS
DOSAGE COMPENSATION
MOLECULAR EVOLUTION
DNA POLYMORPHISM
DEGENERATION
ACCUMULATION
topic BACKGROUND SELECTION
ASEXUAL POPULATIONS
STATISTICAL TESTS
Y-CHROMOSOMES
DELETERIOUS MUTATIONS
DOSAGE COMPENSATION
MOLECULAR EVOLUTION
DNA POLYMORPHISM
DEGENERATION
ACCUMULATION
description The levels and patterns of variation at a neutral locus are analyzed in a haploid asexual population Undergoing accumulation of deleterious mutations due to Muller's ratchet. We find that the movement Of Muller's ratchet can be associated with a considerable reduction in genetic diversity below classical neutral expectation. The extent to which variability is reduced is a function Of the deleterious initiation rate, the fitness effects of the Imitations, and the population size. Approximate analytical expressions for the expected genetic diversity are compared with simulation results under two different models of deleterious imitations: a model where all deleterious imitations have equal effects and a model where there are two classes of deleterious imitations. We also find that Muller's ratchet can produce a considerable distortion in the neutral frequency spectrum toward an excess of rare variants.
publishDate 2002
dc.date.none.fl_str_mv 2002-06
2002-06-01T00:00:00Z
2010-03-31T08:59:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/96
url http://hdl.handle.net/10400.7/96
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0016-6731
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817549559842209792