Voltammetric behaviour of mitoxantrone at a DNA-biosensor

Detalhes bibliográficos
Autor(a) principal: Brett, A. M. Oliveira
Data de Publicação: 1998
Outros Autores: Macedo, T. R. A., Raimundo, D., Marques, M. H., Serrano, S. H. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5278
https://doi.org/10.1016/S0956-5663(98)00053-0
Resumo: The surface of an electrochemical glassy carbon electrode was modified with a layer of double-stranded DNA (dsDNA) or with double-stranded DNA conditioned in single-stranded DNA (ssDNA) and was used to investigate mitoxantrone-DNA interactions. Differential pulse and square wave voltammetry were applied to develop an electroanalytical procedure for the determination of mitoxantrone and evaluate its interaction with dsDNA or ssDNA immobilized on the electrode surface. The results demonstrate that MTX interaction with DNA is not specific to either guanine or adenine bases. The kinetics of the mitoxantrone-DNA interaction is slow and damage to DNA was followed with time.
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spelling Voltammetric behaviour of mitoxantrone at a DNA-biosensorBioelectrochemistryDNA interactionMitoxantroneDNA-biosensorVoltammetryThe surface of an electrochemical glassy carbon electrode was modified with a layer of double-stranded DNA (dsDNA) or with double-stranded DNA conditioned in single-stranded DNA (ssDNA) and was used to investigate mitoxantrone-DNA interactions. Differential pulse and square wave voltammetry were applied to develop an electroanalytical procedure for the determination of mitoxantrone and evaluate its interaction with dsDNA or ssDNA immobilized on the electrode surface. The results demonstrate that MTX interaction with DNA is not specific to either guanine or adenine bases. The kinetics of the mitoxantrone-DNA interaction is slow and damage to DNA was followed with time.http://www.sciencedirect.com/science/article/B6TFC-3V7468X-M/1/0e51372fcf9dc0c815a23de2d3e087951998info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5278http://hdl.handle.net/10316/5278https://doi.org/10.1016/S0956-5663(98)00053-0engBiosensors and Bioelectronics. 13:7-8 (1998) 861-867Brett, A. M. OliveiraMacedo, T. R. A.Raimundo, D.Marques, M. H.Serrano, S. H. P.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-09-22T09:26:24Zoai:estudogeral.uc.pt:10316/5278Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:39.204009Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Voltammetric behaviour of mitoxantrone at a DNA-biosensor
title Voltammetric behaviour of mitoxantrone at a DNA-biosensor
spellingShingle Voltammetric behaviour of mitoxantrone at a DNA-biosensor
Brett, A. M. Oliveira
Bioelectrochemistry
DNA interaction
Mitoxantrone
DNA-biosensor
Voltammetry
title_short Voltammetric behaviour of mitoxantrone at a DNA-biosensor
title_full Voltammetric behaviour of mitoxantrone at a DNA-biosensor
title_fullStr Voltammetric behaviour of mitoxantrone at a DNA-biosensor
title_full_unstemmed Voltammetric behaviour of mitoxantrone at a DNA-biosensor
title_sort Voltammetric behaviour of mitoxantrone at a DNA-biosensor
author Brett, A. M. Oliveira
author_facet Brett, A. M. Oliveira
Macedo, T. R. A.
Raimundo, D.
Marques, M. H.
Serrano, S. H. P.
author_role author
author2 Macedo, T. R. A.
Raimundo, D.
Marques, M. H.
Serrano, S. H. P.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Brett, A. M. Oliveira
Macedo, T. R. A.
Raimundo, D.
Marques, M. H.
Serrano, S. H. P.
dc.subject.por.fl_str_mv Bioelectrochemistry
DNA interaction
Mitoxantrone
DNA-biosensor
Voltammetry
topic Bioelectrochemistry
DNA interaction
Mitoxantrone
DNA-biosensor
Voltammetry
description The surface of an electrochemical glassy carbon electrode was modified with a layer of double-stranded DNA (dsDNA) or with double-stranded DNA conditioned in single-stranded DNA (ssDNA) and was used to investigate mitoxantrone-DNA interactions. Differential pulse and square wave voltammetry were applied to develop an electroanalytical procedure for the determination of mitoxantrone and evaluate its interaction with dsDNA or ssDNA immobilized on the electrode surface. The results demonstrate that MTX interaction with DNA is not specific to either guanine or adenine bases. The kinetics of the mitoxantrone-DNA interaction is slow and damage to DNA was followed with time.
publishDate 1998
dc.date.none.fl_str_mv 1998
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5278
http://hdl.handle.net/10316/5278
https://doi.org/10.1016/S0956-5663(98)00053-0
url http://hdl.handle.net/10316/5278
https://doi.org/10.1016/S0956-5663(98)00053-0
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biosensors and Bioelectronics. 13:7-8 (1998) 861-867
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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