Innate immune response is differentially dysregulated between bipolar disease and schizophrenia

Detalhes bibliográficos
Autor(a) principal: Baumont, Angelica de
Data de Publicação: 2015
Outros Autores: Maschietto, Mariana, Lima, Leandro, Carraro, Dirce Maria, Olivieri, Eloisa Helena, Fiorini, Alex, Barreta, Luiz André Nardin, Palha, Joana Almeida, Belmonte-de-Abreu, Paulo, Filho, Carlos Alberto Moreira, Brentani, Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/50579
Resumo: Articles in Press
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spelling Innate immune response is differentially dysregulated between bipolar disease and schizophreniaSchizophreniaBipolar disorderCo-expressionProtein-protein interaction (PPI)NetworkCiências Médicas::Medicina BásicaScience & TechnologyArticles in PressSchizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions with a neurodevelopmental component. Genetic findings indicate the existence of an overlap in genetic susceptibility across the disorders. Also, image studies provide evidence for a shared neurobiological basis, contributing to a dimensional diagnostic approach. This study aimed to identify the molecular mechanisms that differentiate SZ and BD patients from health controls but also that distinguish both from health individuals. Comparison of gene expression profiling in post-mortem brains of both disorders and health controls (30 cases), followed by a further comparison between 29 BD and 29 SZ revealed 28 differentially expressed genes. These genes were used in co-expression analysesthat revealed the pairs CCR1/SERPINA1, CCR5/HCST, C1QA/CD68, CCR5/S100A11 and SERPINA1/TLR1 as presenting the most significant difference in co-expression between SZ and BD. Next, a protein-protein interaction (PPI) network using the 28 differentially expressed genes as seeds revealed CASP4, TYROBP, CCR1, SERPINA1, CCR5 and C1QA as having a central role in the diseases manifestation. Both co-expression and network topological analyses pointed to genes related to microglia functions. Based on this data, we suggest that differences between SZ and BP are due to genes involved with response to stimulus, defense response, immune system process and response to stress biological processes, all having a role in the communication of environmental factors to the cells and associated to microglia.Stanley Medical Research Institute for providing the tissue samples and the patients for donating the samplesinfo:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoBaumont, Angelica deMaschietto, MarianaLima, LeandroCarraro, Dirce MariaOlivieri, Eloisa HelenaFiorini, AlexBarreta, Luiz André NardinPalha, Joana AlmeidaBelmonte-de-Abreu, PauloFilho, Carlos Alberto MoreiraBrentani, Helena20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/50579engde Baumont, A., Maschietto, M., Lima, L., et. al. (2015). Innate immune response is differentially dysregulated between bipolar disease and schizophrenia. Schizophrenia research, 161(2), 215-2210920-99641573-250910.1016/j.schres.2014.10.05525487697http://www.schres-journal.com/article/S0920-9964(14)00652-5/abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:54:35Zoai:repositorium.sdum.uminho.pt:1822/50579Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:54:10.731447Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Innate immune response is differentially dysregulated between bipolar disease and schizophrenia
title Innate immune response is differentially dysregulated between bipolar disease and schizophrenia
spellingShingle Innate immune response is differentially dysregulated between bipolar disease and schizophrenia
Baumont, Angelica de
Schizophrenia
Bipolar disorder
Co-expression
Protein-protein interaction (PPI)
Network
Ciências Médicas::Medicina Básica
Science & Technology
title_short Innate immune response is differentially dysregulated between bipolar disease and schizophrenia
title_full Innate immune response is differentially dysregulated between bipolar disease and schizophrenia
title_fullStr Innate immune response is differentially dysregulated between bipolar disease and schizophrenia
title_full_unstemmed Innate immune response is differentially dysregulated between bipolar disease and schizophrenia
title_sort Innate immune response is differentially dysregulated between bipolar disease and schizophrenia
author Baumont, Angelica de
author_facet Baumont, Angelica de
Maschietto, Mariana
Lima, Leandro
Carraro, Dirce Maria
Olivieri, Eloisa Helena
Fiorini, Alex
Barreta, Luiz André Nardin
Palha, Joana Almeida
Belmonte-de-Abreu, Paulo
Filho, Carlos Alberto Moreira
Brentani, Helena
author_role author
author2 Maschietto, Mariana
Lima, Leandro
Carraro, Dirce Maria
Olivieri, Eloisa Helena
Fiorini, Alex
Barreta, Luiz André Nardin
Palha, Joana Almeida
Belmonte-de-Abreu, Paulo
Filho, Carlos Alberto Moreira
Brentani, Helena
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Baumont, Angelica de
Maschietto, Mariana
Lima, Leandro
Carraro, Dirce Maria
Olivieri, Eloisa Helena
Fiorini, Alex
Barreta, Luiz André Nardin
Palha, Joana Almeida
Belmonte-de-Abreu, Paulo
Filho, Carlos Alberto Moreira
Brentani, Helena
dc.subject.por.fl_str_mv Schizophrenia
Bipolar disorder
Co-expression
Protein-protein interaction (PPI)
Network
Ciências Médicas::Medicina Básica
Science & Technology
topic Schizophrenia
Bipolar disorder
Co-expression
Protein-protein interaction (PPI)
Network
Ciências Médicas::Medicina Básica
Science & Technology
description Articles in Press
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/50579
url http://hdl.handle.net/1822/50579
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv de Baumont, A., Maschietto, M., Lima, L., et. al. (2015). Innate immune response is differentially dysregulated between bipolar disease and schizophrenia. Schizophrenia research, 161(2), 215-221
0920-9964
1573-2509
10.1016/j.schres.2014.10.055
25487697
http://www.schres-journal.com/article/S0920-9964(14)00652-5/abstract
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133140001751040

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