Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/107295 https://doi.org/10.3390/jcm12103421 |
Resumo: | Background: This study aimed to compare brain asymmetry in patients with schizophrenia (SCZ), bipolar disorder (BPD), and healthy controls to test whether asymmetry patterns could discriminate and set boundaries between two partially overlapping severe mental disorders. Methods: We applied a fully automated voxel-based morphometry (VBM) approach to assess structural brain hemispheric asymmetry in magnetic resonance imaging (MRI) anatomical scans in 60 participants (SCZ = 20; BP = 20; healthy controls = 20), all right-handed and matched for gender, age, and education. Results: Significant differences in gray matter asymmetry were found between patients with SCZ and BPD, between SCZ patients and healthy controls (HC), and between BPD patients and HC. We found a higher asymmetry index (AI) in BPD patients when compared to SCZ in Brodmann areas 6, 11, and 37 and anterior cingulate cortex and an AI higher in SCZ patients when compared to BPD in the cerebellum. Conclusion: Our study found significant differences in brain asymmetry between patients with SCZ and BPD. These promising results could be translated to clinical practice, given that structural brain changes detected by MRI are good candidates for exploration as biological markers for differential diagnosis, besides helping to understand disease-specific abnormalities. |
id |
RCAP_68e32a79d4935f90e39cb2acdec6720e |
---|---|
oai_identifier_str |
oai:estudogeral.uc.pt:10316/107295 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorderbipolar disorder; hemispheric asymmetry; magnetic resonance imaging; schizophreniaBackground: This study aimed to compare brain asymmetry in patients with schizophrenia (SCZ), bipolar disorder (BPD), and healthy controls to test whether asymmetry patterns could discriminate and set boundaries between two partially overlapping severe mental disorders. Methods: We applied a fully automated voxel-based morphometry (VBM) approach to assess structural brain hemispheric asymmetry in magnetic resonance imaging (MRI) anatomical scans in 60 participants (SCZ = 20; BP = 20; healthy controls = 20), all right-handed and matched for gender, age, and education. Results: Significant differences in gray matter asymmetry were found between patients with SCZ and BPD, between SCZ patients and healthy controls (HC), and between BPD patients and HC. We found a higher asymmetry index (AI) in BPD patients when compared to SCZ in Brodmann areas 6, 11, and 37 and anterior cingulate cortex and an AI higher in SCZ patients when compared to BPD in the cerebellum. Conclusion: Our study found significant differences in brain asymmetry between patients with SCZ and BPD. These promising results could be translated to clinical practice, given that structural brain changes detected by MRI are good candidates for exploration as biological markers for differential diagnosis, besides helping to understand disease-specific abnormalities.MDPI2023-05-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107295http://hdl.handle.net/10316/107295https://doi.org/10.3390/jcm12103421eng2077-038337240527https://doi.org/10.3390/jcm12103421Pinto, DiogoMartins, RicardoMacedo, AntónioCastelo-Branco, MiguelValente Duarte, JoãoMadeira, Nunoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-28T13:40:34Zoai:estudogeral.uc.pt:10316/107295Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:40.165991Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder |
title |
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder |
spellingShingle |
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder Pinto, Diogo bipolar disorder; hemispheric asymmetry; magnetic resonance imaging; schizophrenia |
title_short |
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder |
title_full |
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder |
title_fullStr |
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder |
title_full_unstemmed |
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder |
title_sort |
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder |
author |
Pinto, Diogo |
author_facet |
Pinto, Diogo Martins, Ricardo Macedo, António Castelo-Branco, Miguel Valente Duarte, João Madeira, Nuno |
author_role |
author |
author2 |
Martins, Ricardo Macedo, António Castelo-Branco, Miguel Valente Duarte, João Madeira, Nuno |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pinto, Diogo Martins, Ricardo Macedo, António Castelo-Branco, Miguel Valente Duarte, João Madeira, Nuno |
dc.subject.por.fl_str_mv |
bipolar disorder; hemispheric asymmetry; magnetic resonance imaging; schizophrenia |
topic |
bipolar disorder; hemispheric asymmetry; magnetic resonance imaging; schizophrenia |
description |
Background: This study aimed to compare brain asymmetry in patients with schizophrenia (SCZ), bipolar disorder (BPD), and healthy controls to test whether asymmetry patterns could discriminate and set boundaries between two partially overlapping severe mental disorders. Methods: We applied a fully automated voxel-based morphometry (VBM) approach to assess structural brain hemispheric asymmetry in magnetic resonance imaging (MRI) anatomical scans in 60 participants (SCZ = 20; BP = 20; healthy controls = 20), all right-handed and matched for gender, age, and education. Results: Significant differences in gray matter asymmetry were found between patients with SCZ and BPD, between SCZ patients and healthy controls (HC), and between BPD patients and HC. We found a higher asymmetry index (AI) in BPD patients when compared to SCZ in Brodmann areas 6, 11, and 37 and anterior cingulate cortex and an AI higher in SCZ patients when compared to BPD in the cerebellum. Conclusion: Our study found significant differences in brain asymmetry between patients with SCZ and BPD. These promising results could be translated to clinical practice, given that structural brain changes detected by MRI are good candidates for exploration as biological markers for differential diagnosis, besides helping to understand disease-specific abnormalities. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-12 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/107295 http://hdl.handle.net/10316/107295 https://doi.org/10.3390/jcm12103421 |
url |
http://hdl.handle.net/10316/107295 https://doi.org/10.3390/jcm12103421 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2077-0383 37240527 https://doi.org/10.3390/jcm12103421 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134123043848192 |