Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy

Detalhes bibliográficos
Autor(a) principal: Hoop, M
Data de Publicação: 2018
Outros Autores: Ribeiro, AS, Rösch, D, Weinand, P, Mendes, N, Mushtaq, F, Chen, X, Shen, Y, Pujante, C, Puigmartí-Luis, J, Paredes, J, Nelson, B, Pêgo, AP, Pané, S
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/121100
Resumo: The use of magnetic nanorobots to activate chemotherapeutic prodrugs represents a promising alternative to current chemotherapeutic treatments. Here, a hybrid nanowire (NW) for targeted bioorthogonally driven activation of the latent chemotherapeutic prodrug 5-fluoro-1-propargyl-uracil (Pro-5-FU) in in vitro and in vivo cancer models is proposed. The NWs are composed of magnetic iron (Fe) and palladium (Pd), a known bioorthogonal catalyst. In vitro tests with a cancer cell line showed no significant cytotoxic effect by the NWs. In contrast, NWs combined with Pro-5-FU lead to a significant reduction of cell viability, similarly to the one induced by its active chemotherapeutic counterpart 5-fluorouracil (5-FU). The reduction in cell viability is attributed to the catalytic activation of Pro-5-FU into 5-FU. To demonstrate their targeted therapeutic abilities, magnetic fields are used to attract the FePd NWs to a predefined area within a cultured cancer cell population, causing a local Pro-5-FU activation, and subsequent cell death in this region. As a proof of concept, NWs are injected in cancer tumor xenografts. The intraperitoneal injection of Pro-5-FU significantly retards tumour growth without causing significant side effects. This work presents a novel chemotherapeutic approach combining nanorobotics and bioorthogonal activation of prodrugs as an efficient alternative to conventional chemotherapy.
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spelling Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer TherapyThe use of magnetic nanorobots to activate chemotherapeutic prodrugs represents a promising alternative to current chemotherapeutic treatments. Here, a hybrid nanowire (NW) for targeted bioorthogonally driven activation of the latent chemotherapeutic prodrug 5-fluoro-1-propargyl-uracil (Pro-5-FU) in in vitro and in vivo cancer models is proposed. The NWs are composed of magnetic iron (Fe) and palladium (Pd), a known bioorthogonal catalyst. In vitro tests with a cancer cell line showed no significant cytotoxic effect by the NWs. In contrast, NWs combined with Pro-5-FU lead to a significant reduction of cell viability, similarly to the one induced by its active chemotherapeutic counterpart 5-fluorouracil (5-FU). The reduction in cell viability is attributed to the catalytic activation of Pro-5-FU into 5-FU. To demonstrate their targeted therapeutic abilities, magnetic fields are used to attract the FePd NWs to a predefined area within a cultured cancer cell population, causing a local Pro-5-FU activation, and subsequent cell death in this region. As a proof of concept, NWs are injected in cancer tumor xenografts. The intraperitoneal injection of Pro-5-FU significantly retards tumour growth without causing significant side effects. This work presents a novel chemotherapeutic approach combining nanorobotics and bioorthogonal activation of prodrugs as an efficient alternative to conventional chemotherapy.Wiley-VCH Verlag20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/121100eng1616-301X10.1002/adfm.201705920Hoop, MRibeiro, ASRösch, DWeinand, PMendes, NMushtaq, FChen, XShen, YPujante, CPuigmartí-Luis, JParedes, JNelson, BPêgo, APPané, Sinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:40:31Zoai:repositorio-aberto.up.pt:10216/121100Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:24:34.526035Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy
title Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy
spellingShingle Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy
Hoop, M
title_short Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy
title_full Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy
title_fullStr Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy
title_full_unstemmed Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy
title_sort Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy
author Hoop, M
author_facet Hoop, M
Ribeiro, AS
Rösch, D
Weinand, P
Mendes, N
Mushtaq, F
Chen, X
Shen, Y
Pujante, C
Puigmartí-Luis, J
Paredes, J
Nelson, B
Pêgo, AP
Pané, S
author_role author
author2 Ribeiro, AS
Rösch, D
Weinand, P
Mendes, N
Mushtaq, F
Chen, X
Shen, Y
Pujante, C
Puigmartí-Luis, J
Paredes, J
Nelson, B
Pêgo, AP
Pané, S
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hoop, M
Ribeiro, AS
Rösch, D
Weinand, P
Mendes, N
Mushtaq, F
Chen, X
Shen, Y
Pujante, C
Puigmartí-Luis, J
Paredes, J
Nelson, B
Pêgo, AP
Pané, S
description The use of magnetic nanorobots to activate chemotherapeutic prodrugs represents a promising alternative to current chemotherapeutic treatments. Here, a hybrid nanowire (NW) for targeted bioorthogonally driven activation of the latent chemotherapeutic prodrug 5-fluoro-1-propargyl-uracil (Pro-5-FU) in in vitro and in vivo cancer models is proposed. The NWs are composed of magnetic iron (Fe) and palladium (Pd), a known bioorthogonal catalyst. In vitro tests with a cancer cell line showed no significant cytotoxic effect by the NWs. In contrast, NWs combined with Pro-5-FU lead to a significant reduction of cell viability, similarly to the one induced by its active chemotherapeutic counterpart 5-fluorouracil (5-FU). The reduction in cell viability is attributed to the catalytic activation of Pro-5-FU into 5-FU. To demonstrate their targeted therapeutic abilities, magnetic fields are used to attract the FePd NWs to a predefined area within a cultured cancer cell population, causing a local Pro-5-FU activation, and subsequent cell death in this region. As a proof of concept, NWs are injected in cancer tumor xenografts. The intraperitoneal injection of Pro-5-FU significantly retards tumour growth without causing significant side effects. This work presents a novel chemotherapeutic approach combining nanorobotics and bioorthogonal activation of prodrugs as an efficient alternative to conventional chemotherapy.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/121100
url https://hdl.handle.net/10216/121100
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1616-301X
10.1002/adfm.201705920
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH Verlag
publisher.none.fl_str_mv Wiley-VCH Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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