The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models

Detalhes bibliográficos
Autor(a) principal: Oliveira, Rui C.
Data de Publicação: 2020
Outros Autores: Abrantes, Ana Margarida, Tralhão, José Guilherme, Botelho, Maria Filomena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/105526
https://doi.org/10.1002/ame2.12102
Resumo: Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models.
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spelling The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic modelscolorectal cancermouse modelorthotopic modelColorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models.John Wiley and Sons Inc2020-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/105526http://hdl.handle.net/10316/105526https://doi.org/10.1002/ame2.12102eng2576-20952576-2095Oliveira, Rui C.Abrantes, Ana MargaridaTralhão, José GuilhermeBotelho, Maria Filomenainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T10:15:28Zoai:estudogeral.uc.pt:10316/105526Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:05.396912Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models
title The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models
spellingShingle The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models
Oliveira, Rui C.
colorectal cancer
mouse model
orthotopic model
title_short The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models
title_full The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models
title_fullStr The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models
title_full_unstemmed The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models
title_sort The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models
author Oliveira, Rui C.
author_facet Oliveira, Rui C.
Abrantes, Ana Margarida
Tralhão, José Guilherme
Botelho, Maria Filomena
author_role author
author2 Abrantes, Ana Margarida
Tralhão, José Guilherme
Botelho, Maria Filomena
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira, Rui C.
Abrantes, Ana Margarida
Tralhão, José Guilherme
Botelho, Maria Filomena
dc.subject.por.fl_str_mv colorectal cancer
mouse model
orthotopic model
topic colorectal cancer
mouse model
orthotopic model
description Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/105526
http://hdl.handle.net/10316/105526
https://doi.org/10.1002/ame2.12102
url http://hdl.handle.net/10316/105526
https://doi.org/10.1002/ame2.12102
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2576-2095
2576-2095
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley and Sons Inc
publisher.none.fl_str_mv John Wiley and Sons Inc
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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