Experimental Murine Models for Colorectal Cancer Research
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/59016 |
Resumo: | Simple Summary In its early stages, colorectal cancer (CRC) is a localized tumor, but when it metastasizes, it has dramatic consequences. Murine models in CRC research are important tools for advancing the knowledge in diagnostic and treatment of this pathology. The present review aims to provide a variety of murine models in CRC research describing their particular advantages and drawbacks. Abstract Colorectal cancer (CRC) is the third most prevalent malignancy worldwide and in both sexes. Numerous animal models for CRC have been established to study its biology, namely carcinogen-induced models (CIMs) and genetically engineered mouse models (GEMMs). CIMs are valuable for assessing colitis-related carcinogenesis and studying chemoprevention. On the other hand, CRC GEMMs have proven to be useful for evaluating the tumor microenvironment and systemic immune responses, which have contributed to the discovery of novel therapeutic approaches. Although metastatic disease can be induced by orthotopic injection of CRC cell lines, the resulting models are not representative of the full genetic diversity of the disease due to the limited number of cell lines suitable for this purpose. On the other hand, patient-derived xenografts (PDX) are the most reliable for preclinical drug development due to their ability to retain pathological and molecular characteristics. In this review, the authors discuss the various murine CRC models with a focus on their clinical relevance, benefits, and drawbacks. From all models discussed, murine CRC models will continue to be an important tool in advancing our understanding and treatment of this disease, but additional research is required to find a model that can correctly reflect the pathophysiology of CRC. |
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Experimental Murine Models for Colorectal Cancer Researchmurine modelcolorectal canceranimal modelpatient-derived xenograftscarcinogen-induced modelsgenetically engineered mouse modelsmetastatic modelSimple Summary In its early stages, colorectal cancer (CRC) is a localized tumor, but when it metastasizes, it has dramatic consequences. Murine models in CRC research are important tools for advancing the knowledge in diagnostic and treatment of this pathology. The present review aims to provide a variety of murine models in CRC research describing their particular advantages and drawbacks. Abstract Colorectal cancer (CRC) is the third most prevalent malignancy worldwide and in both sexes. Numerous animal models for CRC have been established to study its biology, namely carcinogen-induced models (CIMs) and genetically engineered mouse models (GEMMs). CIMs are valuable for assessing colitis-related carcinogenesis and studying chemoprevention. On the other hand, CRC GEMMs have proven to be useful for evaluating the tumor microenvironment and systemic immune responses, which have contributed to the discovery of novel therapeutic approaches. Although metastatic disease can be induced by orthotopic injection of CRC cell lines, the resulting models are not representative of the full genetic diversity of the disease due to the limited number of cell lines suitable for this purpose. On the other hand, patient-derived xenografts (PDX) are the most reliable for preclinical drug development due to their ability to retain pathological and molecular characteristics. In this review, the authors discuss the various murine CRC models with a focus on their clinical relevance, benefits, and drawbacks. From all models discussed, murine CRC models will continue to be an important tool in advancing our understanding and treatment of this disease, but additional research is required to find a model that can correctly reflect the pathophysiology of CRC.The authors acknowledge Fundação para a Ciência e Tecnologia (FCT) for financial support through projects UIDB/00645/2020, UIDB/04138/2020, UIDP/04138/2020, PTDC/QUI-QIN/0586/2020, as well as PhD fellowship UI/BD/153626/2022.MDPIRepositório da Universidade de LisboaNeto, ÍrisRocha, JoaoGaspar, Maria ManuelaReis, Catarina2023-08-25T09:34:52Z2023-04-302023-05-08T14:10:37Z2023-04-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59016engNeto Í, Rocha J, Gaspar MM, Reis CP. Experimental Murine Models for Colorectal Cancer Research. Cancers [Internet]. 2023 Apr 30;15(9):2570. Available from: http://dx.doi.org/10.3390/cancers15092570cv-prod-326637410.3390/cancers15092570info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:05:36Zoai:repositorio.ul.pt:10451/59016Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:48.518695Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Experimental Murine Models for Colorectal Cancer Research |
title |
Experimental Murine Models for Colorectal Cancer Research |
spellingShingle |
Experimental Murine Models for Colorectal Cancer Research Neto, Íris murine model colorectal cancer animal model patient-derived xenografts carcinogen-induced models genetically engineered mouse models metastatic model |
title_short |
Experimental Murine Models for Colorectal Cancer Research |
title_full |
Experimental Murine Models for Colorectal Cancer Research |
title_fullStr |
Experimental Murine Models for Colorectal Cancer Research |
title_full_unstemmed |
Experimental Murine Models for Colorectal Cancer Research |
title_sort |
Experimental Murine Models for Colorectal Cancer Research |
author |
Neto, Íris |
author_facet |
Neto, Íris Rocha, Joao Gaspar, Maria Manuela Reis, Catarina |
author_role |
author |
author2 |
Rocha, Joao Gaspar, Maria Manuela Reis, Catarina |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Neto, Íris Rocha, Joao Gaspar, Maria Manuela Reis, Catarina |
dc.subject.por.fl_str_mv |
murine model colorectal cancer animal model patient-derived xenografts carcinogen-induced models genetically engineered mouse models metastatic model |
topic |
murine model colorectal cancer animal model patient-derived xenografts carcinogen-induced models genetically engineered mouse models metastatic model |
description |
Simple Summary In its early stages, colorectal cancer (CRC) is a localized tumor, but when it metastasizes, it has dramatic consequences. Murine models in CRC research are important tools for advancing the knowledge in diagnostic and treatment of this pathology. The present review aims to provide a variety of murine models in CRC research describing their particular advantages and drawbacks. Abstract Colorectal cancer (CRC) is the third most prevalent malignancy worldwide and in both sexes. Numerous animal models for CRC have been established to study its biology, namely carcinogen-induced models (CIMs) and genetically engineered mouse models (GEMMs). CIMs are valuable for assessing colitis-related carcinogenesis and studying chemoprevention. On the other hand, CRC GEMMs have proven to be useful for evaluating the tumor microenvironment and systemic immune responses, which have contributed to the discovery of novel therapeutic approaches. Although metastatic disease can be induced by orthotopic injection of CRC cell lines, the resulting models are not representative of the full genetic diversity of the disease due to the limited number of cell lines suitable for this purpose. On the other hand, patient-derived xenografts (PDX) are the most reliable for preclinical drug development due to their ability to retain pathological and molecular characteristics. In this review, the authors discuss the various murine CRC models with a focus on their clinical relevance, benefits, and drawbacks. From all models discussed, murine CRC models will continue to be an important tool in advancing our understanding and treatment of this disease, but additional research is required to find a model that can correctly reflect the pathophysiology of CRC. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-25T09:34:52Z 2023-04-30 2023-05-08T14:10:37Z 2023-04-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/59016 |
url |
http://hdl.handle.net/10451/59016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neto Í, Rocha J, Gaspar MM, Reis CP. Experimental Murine Models for Colorectal Cancer Research. Cancers [Internet]. 2023 Apr 30;15(9):2570. Available from: http://dx.doi.org/10.3390/cancers15092570 cv-prod-3266374 10.3390/cancers15092570 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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