Current advances in solid free-form techniques for osteochondral tissue engineering

Detalhes bibliográficos
Autor(a) principal: Costa, João Bebiano
Data de Publicação: 2018
Outros Autores: Silva-Correia, Joana, Reis, R. L., Oliveira, J. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/56679
Resumo: Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments has increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds' processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.
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spelling Current advances in solid free-form techniques for osteochondral tissue engineeringOsteochondralScaffoldsSolid free-formTissue engineeringScience & TechnologyOsteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments has increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds' processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.The authors would like to thank H2020-MSCA-RISE program, as this work is part of developments carried out in BAMOS project, funded from the European Union's Horizon 2020 research and innovation program under grant agreement Nº 734156. The Portuguese Foundation for Science and Technology (FCT) distinctions attributed to J. Silva-Correia (IF/00115/2015) and J. Miguel Oliveira (IF/01285/2015) under the Investigator FCT program are greatly acknowledged. FCT/MCTES is also acknowledged for the PhD scholarship attributed to J. B. Costa (PD/BD/113803/2015).info:eu-repo/semantics/publishedVersionSpringerUniversidade do MinhoCosta, João BebianoSilva-Correia, JoanaReis, R. L.Oliveira, J. M.2018-062018-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/56679engCosta J. B., Silva-Correia J., Reis R. L., Oliveira J. M. Current Advances in Solid Free-Form Techniques for Osteochondral Tissue Engineering, Bio-Design and Manufacturing, Vol. 1, Issue 3, pp. 171-181, doi:10.1007/s42242-018-0017-y, 20182096-55242522-855210.1007/s42242-018-0017-yhttps://link.springer.com/article/10.1007%2Fs42242-018-0017-yinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:57:58Zoai:repositorium.sdum.uminho.pt:1822/56679Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:47:39.705820Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Current advances in solid free-form techniques for osteochondral tissue engineering
title Current advances in solid free-form techniques for osteochondral tissue engineering
spellingShingle Current advances in solid free-form techniques for osteochondral tissue engineering
Costa, João Bebiano
Osteochondral
Scaffolds
Solid free-form
Tissue engineering
Science & Technology
title_short Current advances in solid free-form techniques for osteochondral tissue engineering
title_full Current advances in solid free-form techniques for osteochondral tissue engineering
title_fullStr Current advances in solid free-form techniques for osteochondral tissue engineering
title_full_unstemmed Current advances in solid free-form techniques for osteochondral tissue engineering
title_sort Current advances in solid free-form techniques for osteochondral tissue engineering
author Costa, João Bebiano
author_facet Costa, João Bebiano
Silva-Correia, Joana
Reis, R. L.
Oliveira, J. M.
author_role author
author2 Silva-Correia, Joana
Reis, R. L.
Oliveira, J. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Costa, João Bebiano
Silva-Correia, Joana
Reis, R. L.
Oliveira, J. M.
dc.subject.por.fl_str_mv Osteochondral
Scaffolds
Solid free-form
Tissue engineering
Science & Technology
topic Osteochondral
Scaffolds
Solid free-form
Tissue engineering
Science & Technology
description Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments has increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds' processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
2018-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/56679
url https://hdl.handle.net/1822/56679
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Costa J. B., Silva-Correia J., Reis R. L., Oliveira J. M. Current Advances in Solid Free-Form Techniques for Osteochondral Tissue Engineering, Bio-Design and Manufacturing, Vol. 1, Issue 3, pp. 171-181, doi:10.1007/s42242-018-0017-y, 2018
2096-5524
2522-8552
10.1007/s42242-018-0017-y
https://link.springer.com/article/10.1007%2Fs42242-018-0017-y
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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