Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/20410 |
Resumo: | Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents. |
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Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquineAntimalarialBlood-stageFatty acidIonic liquidLiver-stagePlasmodiumSAILSurface activityInspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.Chemistry EuropeRepositório Científico do Instituto Politécnico do PortoSilva, Ana TeresaOliveira, Isabel S.Gomes, JoanaAguiar, LuísaFontinha, DianaDuarte, DeniseNogueira, FátimaPrudêncio, MiguelMarques, Eduardo F.Teixeira, CátiaFerraz, RicardoGomes, Paula2022-04-27T16:41:31Z2021-12-092021-12-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/20410engSilva, A. T., Oliveira, I. S., Gomes, J., Aguiar, L., Fontinha, D., Duarte, D., Nogueira, F., Prudêncio, M., Marques, E. F., Teixeira, C., Ferraz, R., & Gomes, P. (2021). Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine. ChemMedChem, 17(5), e202100650. https://doi.org/https://doi.org/10.1002/cmdc.2021006501860-717910.1002/cmdc.20210+K740:K74206501860-7187metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:15:55Zoai:recipp.ipp.pt:10400.22/20410Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:40:28.894632Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine |
title |
Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine |
spellingShingle |
Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine Silva, Ana Teresa Antimalarial Blood-stage Fatty acid Ionic liquid Liver-stage Plasmodium SAIL Surface activity |
title_short |
Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine |
title_full |
Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine |
title_fullStr |
Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine |
title_full_unstemmed |
Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine |
title_sort |
Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine |
author |
Silva, Ana Teresa |
author_facet |
Silva, Ana Teresa Oliveira, Isabel S. Gomes, Joana Aguiar, Luísa Fontinha, Diana Duarte, Denise Nogueira, Fátima Prudêncio, Miguel Marques, Eduardo F. Teixeira, Cátia Ferraz, Ricardo Gomes, Paula |
author_role |
author |
author2 |
Oliveira, Isabel S. Gomes, Joana Aguiar, Luísa Fontinha, Diana Duarte, Denise Nogueira, Fátima Prudêncio, Miguel Marques, Eduardo F. Teixeira, Cátia Ferraz, Ricardo Gomes, Paula |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Silva, Ana Teresa Oliveira, Isabel S. Gomes, Joana Aguiar, Luísa Fontinha, Diana Duarte, Denise Nogueira, Fátima Prudêncio, Miguel Marques, Eduardo F. Teixeira, Cátia Ferraz, Ricardo Gomes, Paula |
dc.subject.por.fl_str_mv |
Antimalarial Blood-stage Fatty acid Ionic liquid Liver-stage Plasmodium SAIL Surface activity |
topic |
Antimalarial Blood-stage Fatty acid Ionic liquid Liver-stage Plasmodium SAIL Surface activity |
description |
Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-09 2021-12-09T00:00:00Z 2022-04-27T16:41:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/20410 |
url |
http://hdl.handle.net/10400.22/20410 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Silva, A. T., Oliveira, I. S., Gomes, J., Aguiar, L., Fontinha, D., Duarte, D., Nogueira, F., Prudêncio, M., Marques, E. F., Teixeira, C., Ferraz, R., & Gomes, P. (2021). Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine. ChemMedChem, 17(5), e202100650. https://doi.org/https://doi.org/10.1002/cmdc.202100650 1860-7179 10.1002/cmdc.20210+K740:K7420650 1860-7187 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Chemistry Europe |
publisher.none.fl_str_mv |
Chemistry Europe |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131493461655552 |