Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine

Detalhes bibliográficos
Autor(a) principal: Silva, Ana Teresa
Data de Publicação: 2021
Outros Autores: Oliveira, Isabel S., Gomes, Joana, Aguiar, Luísa, Fontinha, Diana, Duarte, Denise, Nogueira, Fátima, Prudêncio, Miguel, Marques, Eduardo F., Teixeira, Cátia, Ferraz, Ricardo, Gomes, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/20410
Resumo: Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.
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spelling Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquineAntimalarialBlood-stageFatty acidIonic liquidLiver-stagePlasmodiumSAILSurface activityInspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.Chemistry EuropeRepositório Científico do Instituto Politécnico do PortoSilva, Ana TeresaOliveira, Isabel S.Gomes, JoanaAguiar, LuísaFontinha, DianaDuarte, DeniseNogueira, FátimaPrudêncio, MiguelMarques, Eduardo F.Teixeira, CátiaFerraz, RicardoGomes, Paula2022-04-27T16:41:31Z2021-12-092021-12-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/20410engSilva, A. T., Oliveira, I. S., Gomes, J., Aguiar, L., Fontinha, D., Duarte, D., Nogueira, F., Prudêncio, M., Marques, E. F., Teixeira, C., Ferraz, R., & Gomes, P. (2021). Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine. ChemMedChem, 17(5), e202100650. https://doi.org/https://doi.org/10.1002/cmdc.2021006501860-717910.1002/cmdc.20210+K740:K74206501860-7187metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:15:55Zoai:recipp.ipp.pt:10400.22/20410Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:40:28.894632Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine
title Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine
spellingShingle Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine
Silva, Ana Teresa
Antimalarial
Blood-stage
Fatty acid
Ionic liquid
Liver-stage
Plasmodium
SAIL
Surface activity
title_short Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine
title_full Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine
title_fullStr Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine
title_full_unstemmed Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine
title_sort Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase the blood-stage antimalarial activity of primaquine
author Silva, Ana Teresa
author_facet Silva, Ana Teresa
Oliveira, Isabel S.
Gomes, Joana
Aguiar, Luísa
Fontinha, Diana
Duarte, Denise
Nogueira, Fátima
Prudêncio, Miguel
Marques, Eduardo F.
Teixeira, Cátia
Ferraz, Ricardo
Gomes, Paula
author_role author
author2 Oliveira, Isabel S.
Gomes, Joana
Aguiar, Luísa
Fontinha, Diana
Duarte, Denise
Nogueira, Fátima
Prudêncio, Miguel
Marques, Eduardo F.
Teixeira, Cátia
Ferraz, Ricardo
Gomes, Paula
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Silva, Ana Teresa
Oliveira, Isabel S.
Gomes, Joana
Aguiar, Luísa
Fontinha, Diana
Duarte, Denise
Nogueira, Fátima
Prudêncio, Miguel
Marques, Eduardo F.
Teixeira, Cátia
Ferraz, Ricardo
Gomes, Paula
dc.subject.por.fl_str_mv Antimalarial
Blood-stage
Fatty acid
Ionic liquid
Liver-stage
Plasmodium
SAIL
Surface activity
topic Antimalarial
Blood-stage
Fatty acid
Ionic liquid
Liver-stage
Plasmodium
SAIL
Surface activity
description Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-09
2021-12-09T00:00:00Z
2022-04-27T16:41:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/20410
url http://hdl.handle.net/10400.22/20410
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, A. T., Oliveira, I. S., Gomes, J., Aguiar, L., Fontinha, D., Duarte, D., Nogueira, F., Prudêncio, M., Marques, E. F., Teixeira, C., Ferraz, R., & Gomes, P. (2021). Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine. ChemMedChem, 17(5), e202100650. https://doi.org/https://doi.org/10.1002/cmdc.202100650
1860-7179
10.1002/cmdc.20210+K740:K7420650
1860-7187
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Chemistry Europe
publisher.none.fl_str_mv Chemistry Europe
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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