Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://hdl.handle.net/1822/58006 |
Resumo: | In Press, Corrected Proof |
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7160 |
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Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexesSex differencesEnriched environmentHippocampusReceptorsSerotoninDopamineCiências Médicas::Medicina BásicaScience & TechnologyIn Press, Corrected ProofEnvironmental enrichment (EE), comprising positive physical (exercise) and cognitive stimuli, influences neuronal structure and usually improves brain function. The promise of EE as a preventative strategy against neuropsychiatric disease is especially high during early postnatal development when the brain is still amenable to reorganization. Despite the fact that male and female brains differ in terms of connectivity and function that may reflect early life experiences, knowledge of the neural substrates and mechanisms by which such changes arise remains limited. This study compared the impact of EE combined with physical activity on neuroplasticity and its functional consequences in adult male and female rats; EE was provided during the first 3 months of life and our analysis focused on the hippocampus, an area implicated in cognitive behavior as well as the neuroendocrine response to stress. Both male and female rats reared in EE displayed better object recognition memory than their control counterparts. Interestingly, sex differences were revealed in the effects of EE on time spent exploring the objects during this test. Independently of sex, EE increased hippocampal turnover rates of dopamine and serotonin and reduced expression of 5-HT1A receptors; in addition, EE upregulated expression of synaptophysin, a presynaptic protein, in the hippocampus. As compared to their respective controls, EE-exposed males exhibited parallel increases in phosphorylated Tau and the GluN2B receptor, whereas females responded to EE with reduced hippocampal levels of glutamate and GluN2B. Together, these observations provide further evidence on the differential effects of EE on markers of hippocampal neuroplasticity in males and females.This work was funded by an ``Education and Lifelong Learning, Supporting Postdoctoral Researchers”, co-financed by the European Social Fund (ESF) and the General Secretariat for Research and Technology, Greece. This work was also supported by the Portuguese North Regional Operational Program (ON.2) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER), the Project Estratégico co-funded by FCT (PEst-C/SAU/LA0026/2013) and the European Regional Development Fund COMPETE (FCOMP-01-0124-FEDER-037,298) as well as the project NORTE-01-0145-FEDER-000,013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER)info:eu-repo/semantics/acceptedVersionElsevierUniversidade do MinhoKokras, N.Sotiropoulos, I.Besinis, D.Tzouveka, E. L.Almeida, O. F. X.Sousa, NunoDalla, C.20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/58006engKokras, N., Sotiropoulos, I., Besinis, D., Tzouveka, E. L., et. al. (2018). Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes. European Neuropsychopharmacology0924-977X1873-786210.1016/j.euroneuro.2018.11.110730497839https://www.sciencedirect.com/science/article/pii/S0924977X18319680info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:15:35Zoai:repositorium.sdum.uminho.pt:1822/58006Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:08:02.783378Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes |
| title |
Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes |
| spellingShingle |
Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes Kokras, N. Sex differences Enriched environment Hippocampus Receptors Serotonin Dopamine Ciências Médicas::Medicina Básica Science & Technology |
| title_short |
Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes |
| title_full |
Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes |
| title_fullStr |
Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes |
| title_full_unstemmed |
Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes |
| title_sort |
Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes |
| author |
Kokras, N. |
| author_facet |
Kokras, N. Sotiropoulos, I. Besinis, D. Tzouveka, E. L. Almeida, O. F. X. Sousa, Nuno Dalla, C. |
| author_role |
author |
| author2 |
Sotiropoulos, I. Besinis, D. Tzouveka, E. L. Almeida, O. F. X. Sousa, Nuno Dalla, C. |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Kokras, N. Sotiropoulos, I. Besinis, D. Tzouveka, E. L. Almeida, O. F. X. Sousa, Nuno Dalla, C. |
| dc.subject.por.fl_str_mv |
Sex differences Enriched environment Hippocampus Receptors Serotonin Dopamine Ciências Médicas::Medicina Básica Science & Technology |
| topic |
Sex differences Enriched environment Hippocampus Receptors Serotonin Dopamine Ciências Médicas::Medicina Básica Science & Technology |
| description |
In Press, Corrected Proof |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/58006 |
| url |
https://hdl.handle.net/1822/58006 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Kokras, N., Sotiropoulos, I., Besinis, D., Tzouveka, E. L., et. al. (2018). Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes. European Neuropsychopharmacology 0924-977X 1873-7862 10.1016/j.euroneuro.2018.11.1107 30497839 https://www.sciencedirect.com/science/article/pii/S0924977X18319680 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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