Stress proteins.
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3015 |
Resumo: | Cells from all organisms have developed a remarkable number of strategies to deal with adverse changes in their environment. One of these protective mechanisms is the heat shock response, or stress response, characterized by the extremely rapid increased expression of a selected group of proteins--the heat shock proteins (hsp)--after a sudden increase in the normal cellular growth temperature. The same response takes place when cells are subjected to a wide variety of other stressors: a) environmental assaults: exposure to heavy metals, alcohols, inhibitors of energy metabolism, amino acid analogues; b) states of disease: ischemia, oxidative injury, infectious diseases, immunity disorders and malignancy. On the other hand, some hsp are believed to play an important role in protein maturation steps and in cellular development and differentiation. The understanding of stress response is still incomplete but the promise of its medical applications for fighting against ischemia, infection, immunity diseases and cancer is clearly on the horizon. |
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Stress proteins.Proteínas do Stress.Cells from all organisms have developed a remarkable number of strategies to deal with adverse changes in their environment. One of these protective mechanisms is the heat shock response, or stress response, characterized by the extremely rapid increased expression of a selected group of proteins--the heat shock proteins (hsp)--after a sudden increase in the normal cellular growth temperature. The same response takes place when cells are subjected to a wide variety of other stressors: a) environmental assaults: exposure to heavy metals, alcohols, inhibitors of energy metabolism, amino acid analogues; b) states of disease: ischemia, oxidative injury, infectious diseases, immunity disorders and malignancy. On the other hand, some hsp are believed to play an important role in protein maturation steps and in cellular development and differentiation. The understanding of stress response is still incomplete but the promise of its medical applications for fighting against ischemia, infection, immunity diseases and cancer is clearly on the horizon.Cells from all organisms have developed a remarkable number of strategies to deal with adverse changes in their environment. One of these protective mechanisms is the heat shock response, or stress response, characterized by the extremely rapid increased expression of a selected group of proteins--the heat shock proteins (hsp)--after a sudden increase in the normal cellular growth temperature. The same response takes place when cells are subjected to a wide variety of other stressors: a) environmental assaults: exposure to heavy metals, alcohols, inhibitors of energy metabolism, amino acid analogues; b) states of disease: ischemia, oxidative injury, infectious diseases, immunity disorders and malignancy. On the other hand, some hsp are believed to play an important role in protein maturation steps and in cellular development and differentiation. The understanding of stress response is still incomplete but the promise of its medical applications for fighting against ischemia, infection, immunity diseases and cancer is clearly on the horizon.Ordem dos Médicos1994-12-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3015oai:ojs.www.actamedicaportuguesa.com:article/3015Acta Médica Portuguesa; Vol. 7 No. 12 (1994): Dezembro; 711-5Acta Médica Portuguesa; Vol. 7 N.º 12 (1994): Dezembro; 711-51646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3015https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3015/2357Filipe, P MFernandes, A Cinfo:eu-repo/semantics/openAccess2022-12-20T11:01:29Zoai:ojs.www.actamedicaportuguesa.com:article/3015Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:05.752170Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Stress proteins. Proteínas do Stress. |
title |
Stress proteins. |
spellingShingle |
Stress proteins. Filipe, P M |
title_short |
Stress proteins. |
title_full |
Stress proteins. |
title_fullStr |
Stress proteins. |
title_full_unstemmed |
Stress proteins. |
title_sort |
Stress proteins. |
author |
Filipe, P M |
author_facet |
Filipe, P M Fernandes, A C |
author_role |
author |
author2 |
Fernandes, A C |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Filipe, P M Fernandes, A C |
description |
Cells from all organisms have developed a remarkable number of strategies to deal with adverse changes in their environment. One of these protective mechanisms is the heat shock response, or stress response, characterized by the extremely rapid increased expression of a selected group of proteins--the heat shock proteins (hsp)--after a sudden increase in the normal cellular growth temperature. The same response takes place when cells are subjected to a wide variety of other stressors: a) environmental assaults: exposure to heavy metals, alcohols, inhibitors of energy metabolism, amino acid analogues; b) states of disease: ischemia, oxidative injury, infectious diseases, immunity disorders and malignancy. On the other hand, some hsp are believed to play an important role in protein maturation steps and in cellular development and differentiation. The understanding of stress response is still incomplete but the promise of its medical applications for fighting against ischemia, infection, immunity diseases and cancer is clearly on the horizon. |
publishDate |
1994 |
dc.date.none.fl_str_mv |
1994-12-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3015 oai:ojs.www.actamedicaportuguesa.com:article/3015 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3015 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/3015 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3015 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3015/2357 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
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Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 7 No. 12 (1994): Dezembro; 711-5 Acta Médica Portuguesa; Vol. 7 N.º 12 (1994): Dezembro; 711-5 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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