Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/70432 |
Resumo: | Hemorheological alterations in the majority of metabolic diseases are always connected with blood rheology disturbances, such as the increase of blood and plasma viscosity, cell aggregation enhancement, and reduction of the red blood cells (RBCs) deformability. Thus, the visualizations and measurements of blood cells deformability flowing in microfluidic devices (point-of-care devices) can provide vital information to diagnose early symptoms of blood diseases and consequently to be used as a fast clinical tool for early detection of biomarkers. For instance, RBCs rigidity has been correlated with myocardial infarction, diabetes mellitus, hypertension, among other blood diseases. In order to better understand the blood cells behavior in microfluidic devices, rheological properties analysis is gaining interest by the biomedical committee, since it is strongly dependent on the interactions and mechanical cells proprieties. In addition, the development of blood analogue fluids capable of reproducing the rheological properties of blood and mimic the RBCs behavior at in vitro conditions is crucial for the design, performance and optimization of the microfluidic devices frequently used for personalized medicine. By combining the unique features of the hemorheology and microfluidic technology for single-cell analysis, valuable advances in personalized medicine for new treatments and diagnosis approach can be achieved. |
id |
RCAP_465f7ae83f6fa5bb3eee34d1a7f4d5e5 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/70432 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspectiveHemorheologyBlood diseasesMicrofluidicsSingle-cell analysisRed blood cells deformabilityBlood analoguesScience & TechnologyHemorheological alterations in the majority of metabolic diseases are always connected with blood rheology disturbances, such as the increase of blood and plasma viscosity, cell aggregation enhancement, and reduction of the red blood cells (RBCs) deformability. Thus, the visualizations and measurements of blood cells deformability flowing in microfluidic devices (point-of-care devices) can provide vital information to diagnose early symptoms of blood diseases and consequently to be used as a fast clinical tool for early detection of biomarkers. For instance, RBCs rigidity has been correlated with myocardial infarction, diabetes mellitus, hypertension, among other blood diseases. In order to better understand the blood cells behavior in microfluidic devices, rheological properties analysis is gaining interest by the biomedical committee, since it is strongly dependent on the interactions and mechanical cells proprieties. In addition, the development of blood analogue fluids capable of reproducing the rheological properties of blood and mimic the RBCs behavior at in vitro conditions is crucial for the design, performance and optimization of the microfluidic devices frequently used for personalized medicine. By combining the unique features of the hemorheology and microfluidic technology for single-cell analysis, valuable advances in personalized medicine for new treatments and diagnosis approach can be achieved.This project has been funded by Portuguese national funds of FCT/MCTES (PIDDAC) through the base funding from the following research unit: UIDB/04077/2020, UIDB/00319/2020 and UIDB/00532/2020. The authors are also grateful for the partial funding of FCT through the projects NORTE-01-0145-FEDER-029394, NORTE-01-0145-FEDER-030171, funded by COMPETE2020, NORTE2020, PORTUGAL2020, and FEDER.Diana Pinho acknowledges the PhD scholarship SFRH/BD/89077/2012 attributed by FCT.MDPIUniversidade do MinhoPinho, DianaCarvalho, Violeta MenesesGonçalves, Inês M.Teixeira, S. F. C. F.Lima, Rui Alberto Madeira Macedo2020-12-012020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/70432eng2075-442610.3390/jpm10040249https://www.mdpi.com/2075-4426/10/4/249info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:39:31Zoai:repositorium.sdum.uminho.pt:1822/70432Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:36:08.173793Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective |
title |
Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective |
spellingShingle |
Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective Pinho, Diana Hemorheology Blood diseases Microfluidics Single-cell analysis Red blood cells deformability Blood analogues Science & Technology |
title_short |
Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective |
title_full |
Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective |
title_fullStr |
Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective |
title_full_unstemmed |
Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective |
title_sort |
Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective |
author |
Pinho, Diana |
author_facet |
Pinho, Diana Carvalho, Violeta Meneses Gonçalves, Inês M. Teixeira, S. F. C. F. Lima, Rui Alberto Madeira Macedo |
author_role |
author |
author2 |
Carvalho, Violeta Meneses Gonçalves, Inês M. Teixeira, S. F. C. F. Lima, Rui Alberto Madeira Macedo |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pinho, Diana Carvalho, Violeta Meneses Gonçalves, Inês M. Teixeira, S. F. C. F. Lima, Rui Alberto Madeira Macedo |
dc.subject.por.fl_str_mv |
Hemorheology Blood diseases Microfluidics Single-cell analysis Red blood cells deformability Blood analogues Science & Technology |
topic |
Hemorheology Blood diseases Microfluidics Single-cell analysis Red blood cells deformability Blood analogues Science & Technology |
description |
Hemorheological alterations in the majority of metabolic diseases are always connected with blood rheology disturbances, such as the increase of blood and plasma viscosity, cell aggregation enhancement, and reduction of the red blood cells (RBCs) deformability. Thus, the visualizations and measurements of blood cells deformability flowing in microfluidic devices (point-of-care devices) can provide vital information to diagnose early symptoms of blood diseases and consequently to be used as a fast clinical tool for early detection of biomarkers. For instance, RBCs rigidity has been correlated with myocardial infarction, diabetes mellitus, hypertension, among other blood diseases. In order to better understand the blood cells behavior in microfluidic devices, rheological properties analysis is gaining interest by the biomedical committee, since it is strongly dependent on the interactions and mechanical cells proprieties. In addition, the development of blood analogue fluids capable of reproducing the rheological properties of blood and mimic the RBCs behavior at in vitro conditions is crucial for the design, performance and optimization of the microfluidic devices frequently used for personalized medicine. By combining the unique features of the hemorheology and microfluidic technology for single-cell analysis, valuable advances in personalized medicine for new treatments and diagnosis approach can be achieved. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 2020-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/70432 |
url |
http://hdl.handle.net/1822/70432 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2075-4426 10.3390/jpm10040249 https://www.mdpi.com/2075-4426/10/4/249 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132889631162368 |