Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach

Detalhes bibliográficos
Autor(a) principal: Martins, Paula
Data de Publicação: 2017
Outros Autores: Castela, Eduardo, Rocha, Graça, Sena, Cristina, Seiça, Raquel
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726
Resumo: Human immunodeficiency virus infected children and adolescents are a pediatric group with increased risk of premature cardiovascular disease. The virus itself, the antiretroviral therapy and the lifestyle establish a complex interplay of factors that promotes an accelerated atherosclerosis. This process is probably mediated by dyslipidaemia, dysregulation of glucose metabolism, lipodystrophy, inflammation, endothelial dysfunction and a prothrombotic state. The clinical approach to this population in terms of cardiovascular prevention is mainly based on efficient treatment of the infection, reduction of the modifiable risk factors and promotion of lifestyle changes.
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spelling Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical ApproachAterosclerose Precoce na População Pediátrica Infetada pelo VIH: Revisão da Literatura e Abordagem ClínicaAnti-Retroviral AgentsAtherosclerosisChildHIV InfectionsRisk FactorsAntirretroviraisAteroscleroseCriançaFactores de RiscoInfecções por HIVHuman immunodeficiency virus infected children and adolescents are a pediatric group with increased risk of premature cardiovascular disease. The virus itself, the antiretroviral therapy and the lifestyle establish a complex interplay of factors that promotes an accelerated atherosclerosis. This process is probably mediated by dyslipidaemia, dysregulation of glucose metabolism, lipodystrophy, inflammation, endothelial dysfunction and a prothrombotic state. The clinical approach to this population in terms of cardiovascular prevention is mainly based on efficient treatment of the infection, reduction of the modifiable risk factors and promotion of lifestyle changes.As crianças e adolescentes infetados pelo vírus da imunodeficiência humana representam um grupo pediátrico com risco acrescido de doença cardiovascular precoce. O próprio vírus, a terapêutica antirretrovírica e os estilos de vida estabelecem um complexo conjunto interatuante de fatores que promove a aterosclerose acelerada. Este processo é provavelmente mediado por dislipidémia, alterações do metabolismo glicídico, inflamação crónica com disfunção endotelial e um estado pro-trombótico. A abordagem clínica desta população para prevenção cardiovascular é baseada sobretudo num tratamento eficaz da infeção, na redução dos fatores de risco modificáveis e na promoção de hábitos saudáveis.Ordem dos Médicos2017-10-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/vnd.ms-powerpointapplication/vnd.ms-powerpointapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726oai:ojs.www.actamedicaportuguesa.com:article/8726Acta Médica Portuguesa; Vol. 30 No. 10 (2017): October; 742-749Acta Médica Portuguesa; Vol. 30 N.º 10 (2017): Outubro; 742-7491646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/5208https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9062https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9063https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9194https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9322https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9682Direitos de Autor (c) 2017 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessMartins, PaulaCastela, EduardoRocha, GraçaSena, CristinaSeiça, Raquel2022-12-20T11:05:37Zoai:ojs.www.actamedicaportuguesa.com:article/8726Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:38.334220Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
Aterosclerose Precoce na População Pediátrica Infetada pelo VIH: Revisão da Literatura e Abordagem Clínica
title Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
spellingShingle Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
Martins, Paula
Anti-Retroviral Agents
Atherosclerosis
Child
HIV Infections
Risk Factors
Antirretrovirais
Aterosclerose
Criança
Factores de Risco
Infecções por HIV
title_short Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
title_full Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
title_fullStr Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
title_full_unstemmed Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
title_sort Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
author Martins, Paula
author_facet Martins, Paula
Castela, Eduardo
Rocha, Graça
Sena, Cristina
Seiça, Raquel
author_role author
author2 Castela, Eduardo
Rocha, Graça
Sena, Cristina
Seiça, Raquel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Martins, Paula
Castela, Eduardo
Rocha, Graça
Sena, Cristina
Seiça, Raquel
dc.subject.por.fl_str_mv Anti-Retroviral Agents
Atherosclerosis
Child
HIV Infections
Risk Factors
Antirretrovirais
Aterosclerose
Criança
Factores de Risco
Infecções por HIV
topic Anti-Retroviral Agents
Atherosclerosis
Child
HIV Infections
Risk Factors
Antirretrovirais
Aterosclerose
Criança
Factores de Risco
Infecções por HIV
description Human immunodeficiency virus infected children and adolescents are a pediatric group with increased risk of premature cardiovascular disease. The virus itself, the antiretroviral therapy and the lifestyle establish a complex interplay of factors that promotes an accelerated atherosclerosis. This process is probably mediated by dyslipidaemia, dysregulation of glucose metabolism, lipodystrophy, inflammation, endothelial dysfunction and a prothrombotic state. The clinical approach to this population in terms of cardiovascular prevention is mainly based on efficient treatment of the infection, reduction of the modifiable risk factors and promotion of lifestyle changes.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-31
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/5208
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9062
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9063
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9194
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9322
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726/9682
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2017 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2017 Acta Médica Portuguesa
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 30 No. 10 (2017): October; 742-749
Acta Médica Portuguesa; Vol. 30 N.º 10 (2017): Outubro; 742-749
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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