Regulatory landscape of the Hox transcriptome

• Autor(a) principal: Casaca, Ana
• Data de Publicação: 2018
• Outros Autores: Hauswirth, Gabriel M, Bildsoe, Heidi, Mallo, Moisés, McGlinn, Edwina
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.7/904
• topic: Animals; Embryonic Development; Genes, Homeobox; MicroRNAs; RNA, Long Noncoding; Gene Expression Regulation, Developmental; Transcriptome

Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks.