Reassessing the Role of Hox Genes during Vertebrate Development and Evolution
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/908 |
Resumo: | Since their discovery Hox genes have been at the core of the established models explaining the development and evolution of the vertebrate body plan as well as its paired appendages. Recent work brought new light to their role in the patterning processes along the main body axis. These studies show that Hox genes do not control the basic layout of the vertebrate body plan but carry out region-specific patterning instructions loaded on the derivatives of axial progenitors by Hox-independent processes. Furthermore, the finding that Hox clusters are embedded in functional chromatin domains, which critically impacts their expression, has significantly altered our understanding of the mechanisms of Hox gene regulation. This new conceptual framework has broadened our understanding of both limb development and the evolution of vertebrate paired appendages. |
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Reassessing the Role of Hox Genes during Vertebrate Development and EvolutionAnimalsBody PatterningEvolution, MolecularGene Expression Regulation, DevelopmentalGenes, HomeoboxLimb BudsModels, GeneticVertebratesMultigene FamilySince their discovery Hox genes have been at the core of the established models explaining the development and evolution of the vertebrate body plan as well as its paired appendages. Recent work brought new light to their role in the patterning processes along the main body axis. These studies show that Hox genes do not control the basic layout of the vertebrate body plan but carry out region-specific patterning instructions loaded on the derivatives of axial progenitors by Hox-independent processes. Furthermore, the finding that Hox clusters are embedded in functional chromatin domains, which critically impacts their expression, has significantly altered our understanding of the mechanisms of Hox gene regulation. This new conceptual framework has broadened our understanding of both limb development and the evolution of vertebrate paired appendages.ARCAMallo, Moisés2019-08-29T10:50:49Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/908eng10.1016/j.tig.2017.11.007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:19Zoai:arca.igc.gulbenkian.pt:10400.7/908Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:06.784842Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Reassessing the Role of Hox Genes during Vertebrate Development and Evolution |
title |
Reassessing the Role of Hox Genes during Vertebrate Development and Evolution |
spellingShingle |
Reassessing the Role of Hox Genes during Vertebrate Development and Evolution Mallo, Moisés Animals Body Patterning Evolution, Molecular Gene Expression Regulation, Developmental Genes, Homeobox Limb Buds Models, Genetic Vertebrates Multigene Family |
title_short |
Reassessing the Role of Hox Genes during Vertebrate Development and Evolution |
title_full |
Reassessing the Role of Hox Genes during Vertebrate Development and Evolution |
title_fullStr |
Reassessing the Role of Hox Genes during Vertebrate Development and Evolution |
title_full_unstemmed |
Reassessing the Role of Hox Genes during Vertebrate Development and Evolution |
title_sort |
Reassessing the Role of Hox Genes during Vertebrate Development and Evolution |
author |
Mallo, Moisés |
author_facet |
Mallo, Moisés |
author_role |
author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Mallo, Moisés |
dc.subject.por.fl_str_mv |
Animals Body Patterning Evolution, Molecular Gene Expression Regulation, Developmental Genes, Homeobox Limb Buds Models, Genetic Vertebrates Multigene Family |
topic |
Animals Body Patterning Evolution, Molecular Gene Expression Regulation, Developmental Genes, Homeobox Limb Buds Models, Genetic Vertebrates Multigene Family |
description |
Since their discovery Hox genes have been at the core of the established models explaining the development and evolution of the vertebrate body plan as well as its paired appendages. Recent work brought new light to their role in the patterning processes along the main body axis. These studies show that Hox genes do not control the basic layout of the vertebrate body plan but carry out region-specific patterning instructions loaded on the derivatives of axial progenitors by Hox-independent processes. Furthermore, the finding that Hox clusters are embedded in functional chromatin domains, which critically impacts their expression, has significantly altered our understanding of the mechanisms of Hox gene regulation. This new conceptual framework has broadened our understanding of both limb development and the evolution of vertebrate paired appendages. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2019-08-29T10:50:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/908 |
url |
http://hdl.handle.net/10400.7/908 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.tig.2017.11.007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130576572121088 |