Precipitation of hydroxyapatite at 37 °C in a meso oscillatory flow reactor operated in batch at constant power density

• Autor(a) principal: Castro, Filipa
• Data de Publicação: 2013
• Outros Autores: Ferreira, António, Rocha, F. A., Vicente, A. A., Teixeira, J. A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/1822/27482
• topic: Precipitation; Hydroxyapatite; Mixing; Mesoreactor; Oscillatory flow; Science & Technology

A meso oscillatory flow reactor (OFR) was successfully applied for the precipitation of hydroxyapatite (HAp) nanoparticles. Mixing efficiency of the mesoreactor operated batchwise in a vertical tube was evaluated at constant power density, by monitoring variation of hue values upon mixing both spatially and temporally. The best operating conditions for fast mixing and a more homogeneous reaction medium were verified for f = 0.83 Hz and x0 = 4.5 mm. HAp precipitation was then carried out under these conditions at 37 °C for different mixing Ca/P molar ratios. HAp nanoparticles with a mean size (d50) of about 67 nm and a narrow size distribution were obtained. Furthermore, the obtained results show the advantages of the meso-OFR over a stirred tank batch reactor due to the production, about four times faster, of smaller and more uniform HAp nanoparticles. © 2013 American Institute of Chemical Engineers AIChE J, 2013