Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing

• Autor(a) principal: Alves, Andreia
• Data de Publicação: 2020
• Outros Autores: Miguel, Sónia P., Araujo, Andre RTS, Jesús Valle, María José de, Sánchez Navarro, Amparo, Correia, I.J., Ribeiro, MP., Coutinho, Paula
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.6/8971
• topic: Wound dressing; Thermo-reversible hydrogel; Xanthan gum; Konjac glucomannan

Hydrogels are considered to be the most ideal materials for the production of wound dressings since they display a three-dimensional structure that mimics the native extracellular matrix of skin as well as a high-water content, which confers a moist environment at the wound site. Until now, different polymers have been used, alone or blended, for the production of hydrogels aimed for this biomedical application. From the best of our knowledge, the application of a xanthan gum-konjac glucomannan blend has not been used for the production of wound dressings. Herein, a thermo-reversible hydrogel composed of xanthan gum-konjac glucomannan (at different concentrations (1% and 2% w/v) and ratios (50/50 and 60/40)) was produced and characterized. The obtained data emphasize the excellent physicochemical and biological properties of the produced hydrogels, which are suitable for their future application as wound dressings.