TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitis
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.10/837 |
Resumo: | TINU (Tubulo-Interstitial Nephritis and Uveitis) syndrome is a rare disease of unknown aetiology characterised by the association between interstitial nephritis and uveitis. The authors present the cases of two young children whose symptoms began with anorexia and weight loss, associated with renal failure and proteinuria of tubular origin. One child also presented anaemia, glycosuria without hyperglycaemia and microhaematuria. A few months later both developed uveitis. In both cases the renal biopsy showed changes compatible with interstitial nephritis. As interstitial nephritis and uveitis aetiologies were not identified, TINU syndrome was suggested as a possible diagnosis. In both children there was a complete resolution, with one needing systemic steroids and immunosuppressive treatment. TINU syndrome should always be considered in the differential diagnosis of patients with renal and ophthalmologic changes. |
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TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitisInterstitial nephritisTINU syndromeUveitisTINU (Tubulo-Interstitial Nephritis and Uveitis) syndrome is a rare disease of unknown aetiology characterised by the association between interstitial nephritis and uveitis. The authors present the cases of two young children whose symptoms began with anorexia and weight loss, associated with renal failure and proteinuria of tubular origin. One child also presented anaemia, glycosuria without hyperglycaemia and microhaematuria. A few months later both developed uveitis. In both cases the renal biopsy showed changes compatible with interstitial nephritis. As interstitial nephritis and uveitis aetiologies were not identified, TINU syndrome was suggested as a possible diagnosis. In both children there was a complete resolution, with one needing systemic steroids and immunosuppressive treatment. TINU syndrome should always be considered in the differential diagnosis of patients with renal and ophthalmologic changes.Sociedade Portuguesa de NefrologiaRepositório do Hospital Prof. Doutor Fernando FonsecaBento, VCastro, IBatista, JMesquita, J2012-12-28T16:18:34Z2008-01-01T00:00:00Z2008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/837engPort J Nephrol Hypert 2008; 22 (3): 263-2660872-0169info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:51:41Zoai:repositorio.hff.min-saude.pt:10400.10/837Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:52:02.601542Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitis |
title |
TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitis |
spellingShingle |
TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitis Bento, V Interstitial nephritis TINU syndrome Uveitis |
title_short |
TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitis |
title_full |
TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitis |
title_fullStr |
TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitis |
title_full_unstemmed |
TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitis |
title_sort |
TINU syndrome: two clinical cases of tubulo-interstitial nephritis and uveitis |
author |
Bento, V |
author_facet |
Bento, V Castro, I Batista, J Mesquita, J |
author_role |
author |
author2 |
Castro, I Batista, J Mesquita, J |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório do Hospital Prof. Doutor Fernando Fonseca |
dc.contributor.author.fl_str_mv |
Bento, V Castro, I Batista, J Mesquita, J |
dc.subject.por.fl_str_mv |
Interstitial nephritis TINU syndrome Uveitis |
topic |
Interstitial nephritis TINU syndrome Uveitis |
description |
TINU (Tubulo-Interstitial Nephritis and Uveitis) syndrome is a rare disease of unknown aetiology characterised by the association between interstitial nephritis and uveitis. The authors present the cases of two young children whose symptoms began with anorexia and weight loss, associated with renal failure and proteinuria of tubular origin. One child also presented anaemia, glycosuria without hyperglycaemia and microhaematuria. A few months later both developed uveitis. In both cases the renal biopsy showed changes compatible with interstitial nephritis. As interstitial nephritis and uveitis aetiologies were not identified, TINU syndrome was suggested as a possible diagnosis. In both children there was a complete resolution, with one needing systemic steroids and immunosuppressive treatment. TINU syndrome should always be considered in the differential diagnosis of patients with renal and ophthalmologic changes. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01T00:00:00Z 2008-01-01T00:00:00Z 2012-12-28T16:18:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.10/837 |
url |
http://hdl.handle.net/10400.10/837 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Port J Nephrol Hypert 2008; 22 (3): 263-266 0872-0169 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130384593584128 |