New polygenic risk score to predict high myopia in Singapore Chinese children

Detalhes bibliográficos
Autor(a) principal: Lanca, Carla
Data de Publicação: 2021
Outros Autores: Kassam, Irfahan, Patasova, Karina, Foo, Li-Lian, Li, Jonathan, Ang, Marcus, Hoang, Quan V., Teo, Yik-Ying, Hysi, Pirro G., Saw, Seang-Mei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/13585
Resumo: National Medical Research Council Individual Research Grant (NMRC/0975/2005)
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spelling New polygenic risk score to predict high myopia in Singapore Chinese childrenHigh myopiaPolygenic risk scoreChildrenTeenagerEast AsianNational Medical Research Council Individual Research Grant (NMRC/0975/2005)Purpose: The purpose of this study was to develop an Asian polygenic risk score (PRS) to predict high myopia (HM) in Chinese children in the Singapore Cohort of Risk factors for Myopia (SCORM) cohort. Methods: We included children followed from 6 to 11 years old until teenage years (12–18 years old). Cycloplegic autorefraction, ultrasound biometry, Illumina HumanHap 550, or 550 Duo Beadarrays, demographics, and environmental factors data were obtained. The PRS was generated from the Consortium for Refractive Error and Myopia genomewide association study (n = 542,934) and the Strabismus, Amblyopia, and Refractive Error in Singapore children Study (n = 500). The Growing Up in Singapore Towards healthy Outcomes Cohort study (n = 339) was the replication cohort. The outcome was teenage HM (≤ −5.00 D) with predictive performance assessed using the area under the curve (AUC). Results: Mean baseline age ± SD was 7.85 ± 0.84 (n = 1004) and 571 attended the teenage visit; 23.3% had HM. In multivariate analysis, the PRS was associated with a myopic spherical equivalent with an incremental R2 of 0.041 (95% confidence interval [CI] = 0.010, 0.073; P < 0.001). AUC for HM (0.77 [95% CI = 0.71–0.83]) performed better (P = 0.02) with the PRS compared with a model without (0.72 [95% CI = 0.65, 0.78]). Children at the top 25% PRS risk had a 2.34-fold-greater risk of HM (95% CI = 1.53, 3.55; P < 0.001). Conclusions: The new Asian PRS improved the predictive performance to detect children at risk of HM.ARVORCIPLLanca, CarlaKassam, IrfahanPatasova, KarinaFoo, Li-LianLi, JonathanAng, MarcusHoang, Quan V.Teo, Yik-YingHysi, Pirro G.Saw, Seang-Mei2021-07-30T08:24:15Z2021-072021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/13585engLança C, Kassam I, Patasova K, Foo LL, Li J, Ang M, et al. New polygenic risk score to predict high myopia in Singapore Chinese children. Transl Vis Sci Technol. 2021;10(8):26.10.1167/tvst.10.8.26info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:08:35Zoai:repositorio.ipl.pt:10400.21/13585Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:30.361983Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv New polygenic risk score to predict high myopia in Singapore Chinese children
title New polygenic risk score to predict high myopia in Singapore Chinese children
spellingShingle New polygenic risk score to predict high myopia in Singapore Chinese children
Lanca, Carla
High myopia
Polygenic risk score
Children
Teenager
East Asian
title_short New polygenic risk score to predict high myopia in Singapore Chinese children
title_full New polygenic risk score to predict high myopia in Singapore Chinese children
title_fullStr New polygenic risk score to predict high myopia in Singapore Chinese children
title_full_unstemmed New polygenic risk score to predict high myopia in Singapore Chinese children
title_sort New polygenic risk score to predict high myopia in Singapore Chinese children
author Lanca, Carla
author_facet Lanca, Carla
Kassam, Irfahan
Patasova, Karina
Foo, Li-Lian
Li, Jonathan
Ang, Marcus
Hoang, Quan V.
Teo, Yik-Ying
Hysi, Pirro G.
Saw, Seang-Mei
author_role author
author2 Kassam, Irfahan
Patasova, Karina
Foo, Li-Lian
Li, Jonathan
Ang, Marcus
Hoang, Quan V.
Teo, Yik-Ying
Hysi, Pirro G.
Saw, Seang-Mei
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Lanca, Carla
Kassam, Irfahan
Patasova, Karina
Foo, Li-Lian
Li, Jonathan
Ang, Marcus
Hoang, Quan V.
Teo, Yik-Ying
Hysi, Pirro G.
Saw, Seang-Mei
dc.subject.por.fl_str_mv High myopia
Polygenic risk score
Children
Teenager
East Asian
topic High myopia
Polygenic risk score
Children
Teenager
East Asian
description National Medical Research Council Individual Research Grant (NMRC/0975/2005)
publishDate 2021
dc.date.none.fl_str_mv 2021-07-30T08:24:15Z
2021-07
2021-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/13585
url http://hdl.handle.net/10400.21/13585
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lança C, Kassam I, Patasova K, Foo LL, Li J, Ang M, et al. New polygenic risk score to predict high myopia in Singapore Chinese children. Transl Vis Sci Technol. 2021;10(8):26.
10.1167/tvst.10.8.26
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ARVO
publisher.none.fl_str_mv ARVO
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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