New polygenic risk score to predict high myopia in Singapore Chinese children
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/13585 |
Resumo: | National Medical Research Council Individual Research Grant (NMRC/0975/2005) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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New polygenic risk score to predict high myopia in Singapore Chinese childrenHigh myopiaPolygenic risk scoreChildrenTeenagerEast AsianNational Medical Research Council Individual Research Grant (NMRC/0975/2005)Purpose: The purpose of this study was to develop an Asian polygenic risk score (PRS) to predict high myopia (HM) in Chinese children in the Singapore Cohort of Risk factors for Myopia (SCORM) cohort. Methods: We included children followed from 6 to 11 years old until teenage years (12–18 years old). Cycloplegic autorefraction, ultrasound biometry, Illumina HumanHap 550, or 550 Duo Beadarrays, demographics, and environmental factors data were obtained. The PRS was generated from the Consortium for Refractive Error and Myopia genomewide association study (n = 542,934) and the Strabismus, Amblyopia, and Refractive Error in Singapore children Study (n = 500). The Growing Up in Singapore Towards healthy Outcomes Cohort study (n = 339) was the replication cohort. The outcome was teenage HM (≤ −5.00 D) with predictive performance assessed using the area under the curve (AUC). Results: Mean baseline age ± SD was 7.85 ± 0.84 (n = 1004) and 571 attended the teenage visit; 23.3% had HM. In multivariate analysis, the PRS was associated with a myopic spherical equivalent with an incremental R2 of 0.041 (95% confidence interval [CI] = 0.010, 0.073; P < 0.001). AUC for HM (0.77 [95% CI = 0.71–0.83]) performed better (P = 0.02) with the PRS compared with a model without (0.72 [95% CI = 0.65, 0.78]). Children at the top 25% PRS risk had a 2.34-fold-greater risk of HM (95% CI = 1.53, 3.55; P < 0.001). Conclusions: The new Asian PRS improved the predictive performance to detect children at risk of HM.ARVORCIPLLanca, CarlaKassam, IrfahanPatasova, KarinaFoo, Li-LianLi, JonathanAng, MarcusHoang, Quan V.Teo, Yik-YingHysi, Pirro G.Saw, Seang-Mei2021-07-30T08:24:15Z2021-072021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/13585engLança C, Kassam I, Patasova K, Foo LL, Li J, Ang M, et al. New polygenic risk score to predict high myopia in Singapore Chinese children. Transl Vis Sci Technol. 2021;10(8):26.10.1167/tvst.10.8.26info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:08:35Zoai:repositorio.ipl.pt:10400.21/13585Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:30.361983Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
New polygenic risk score to predict high myopia in Singapore Chinese children |
title |
New polygenic risk score to predict high myopia in Singapore Chinese children |
spellingShingle |
New polygenic risk score to predict high myopia in Singapore Chinese children Lanca, Carla High myopia Polygenic risk score Children Teenager East Asian |
title_short |
New polygenic risk score to predict high myopia in Singapore Chinese children |
title_full |
New polygenic risk score to predict high myopia in Singapore Chinese children |
title_fullStr |
New polygenic risk score to predict high myopia in Singapore Chinese children |
title_full_unstemmed |
New polygenic risk score to predict high myopia in Singapore Chinese children |
title_sort |
New polygenic risk score to predict high myopia in Singapore Chinese children |
author |
Lanca, Carla |
author_facet |
Lanca, Carla Kassam, Irfahan Patasova, Karina Foo, Li-Lian Li, Jonathan Ang, Marcus Hoang, Quan V. Teo, Yik-Ying Hysi, Pirro G. Saw, Seang-Mei |
author_role |
author |
author2 |
Kassam, Irfahan Patasova, Karina Foo, Li-Lian Li, Jonathan Ang, Marcus Hoang, Quan V. Teo, Yik-Ying Hysi, Pirro G. Saw, Seang-Mei |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Lanca, Carla Kassam, Irfahan Patasova, Karina Foo, Li-Lian Li, Jonathan Ang, Marcus Hoang, Quan V. Teo, Yik-Ying Hysi, Pirro G. Saw, Seang-Mei |
dc.subject.por.fl_str_mv |
High myopia Polygenic risk score Children Teenager East Asian |
topic |
High myopia Polygenic risk score Children Teenager East Asian |
description |
National Medical Research Council Individual Research Grant (NMRC/0975/2005) |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-30T08:24:15Z 2021-07 2021-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/13585 |
url |
http://hdl.handle.net/10400.21/13585 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lança C, Kassam I, Patasova K, Foo LL, Li J, Ang M, et al. New polygenic risk score to predict high myopia in Singapore Chinese children. Transl Vis Sci Technol. 2021;10(8):26. 10.1167/tvst.10.8.26 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
ARVO |
publisher.none.fl_str_mv |
ARVO |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133486097891328 |