Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females

Detalhes bibliográficos
Autor(a) principal: Sousa, Sara
Data de Publicação: 2023
Outros Autores: Pestana, Diogo, Faria, Gil, Delerue-Matos, Cristina, Calhau, Conceição, Fernandes Domingues, Valentina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158379
Resumo: Funding Information: S. Sousa is grateful to FCT and European Social Fund through Programa Operacional Capital Humano for the Ph.D . grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). The authors thank the General Surgery Department of Hospital de São João (Porto, Portugal) and to all patients that consented to participate. Funding Information: This work was financially supported by Portuguese national funds through projects UIDB/50006/2020 , UIDP/50006/2020 , and LA/P/0008/2020 , from the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência , Tecnologia e Ensino Superior . Funding Information: S. Sousa is grateful to Fundação para a Ciência e a Tecnologia and European Social Fund through Programa Operacional Capital Humano for the Ph.D . grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). Publisher Copyright: © 2023 Elsevier Ltd
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spelling Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese femalesImplication of menopause and ageingAdipocytesBiochemical parametersLipidMetabolismObesityWomenClinical BiochemistryCell BiologySDG 3 - Good Health and Well-beingFunding Information: S. Sousa is grateful to FCT and European Social Fund through Programa Operacional Capital Humano for the Ph.D . grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). The authors thank the General Surgery Department of Hospital de São João (Porto, Portugal) and to all patients that consented to participate. Funding Information: This work was financially supported by Portuguese national funds through projects UIDB/50006/2020 , UIDP/50006/2020 , and LA/P/0008/2020 , from the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência , Tecnologia e Ensino Superior . Funding Information: S. Sousa is grateful to Fundação para a Ciência e a Tecnologia and European Social Fund through Programa Operacional Capital Humano for the Ph.D . grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). Publisher Copyright: © 2023 Elsevier LtdFatty acids (FA) are biomarkers of metabolic dysfunction. Adipose tissue is the largest reservoir of FA and acts differently in obese individuals. Menopause by itself significantly alters metabolism, lipid metabolism dysregulation, and adipose tissue distribution. How adipose tissue FA alters an obese individual's metabolism depending on a female's menopausal status is yet poorly understood. Hence, the subcutaneous (scAT) and visceral adipose tissue (vAT) FA profile for 173 obese premenopausal and postmenopausal women was measured and associated with biochemical parameters. scAT and vAT FA profiles were distinct by themselves and in menopause. In total 816 associations were found with biochemical parameters, where only 58 were independent of the menopausal status. The associations found to emphasize the importance of assessing the adipose tissue FA profile and how their behavior changes with menopause. The FA are crucial in metabolic processes and can be helpful biomarkers in the prevention/treatment and follow-up of female obesity.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSousa, SaraPestana, DiogoFaria, GilDelerue-Matos, CristinaCalhau, ConceiçãoFernandes Domingues, Valentina2023-09-27T22:25:16Z2023-082023-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158379eng0952-3278PURE: 70039444https://doi.org/10.1016/j.plefa.2023.102581info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:44Zoai:run.unl.pt:10362/158379Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:06.283419Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females
Implication of menopause and ageing
title Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females
spellingShingle Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females
Sousa, Sara
Adipocytes
Biochemical parameters
Lipid
Metabolism
Obesity
Women
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
title_short Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females
title_full Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females
title_fullStr Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females
title_full_unstemmed Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females
title_sort Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females
author Sousa, Sara
author_facet Sousa, Sara
Pestana, Diogo
Faria, Gil
Delerue-Matos, Cristina
Calhau, Conceição
Fernandes Domingues, Valentina
author_role author
author2 Pestana, Diogo
Faria, Gil
Delerue-Matos, Cristina
Calhau, Conceição
Fernandes Domingues, Valentina
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Sousa, Sara
Pestana, Diogo
Faria, Gil
Delerue-Matos, Cristina
Calhau, Conceição
Fernandes Domingues, Valentina
dc.subject.por.fl_str_mv Adipocytes
Biochemical parameters
Lipid
Metabolism
Obesity
Women
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
topic Adipocytes
Biochemical parameters
Lipid
Metabolism
Obesity
Women
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
description Funding Information: S. Sousa is grateful to FCT and European Social Fund through Programa Operacional Capital Humano for the Ph.D . grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). The authors thank the General Surgery Department of Hospital de São João (Porto, Portugal) and to all patients that consented to participate. Funding Information: This work was financially supported by Portuguese national funds through projects UIDB/50006/2020 , UIDP/50006/2020 , and LA/P/0008/2020 , from the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência , Tecnologia e Ensino Superior . Funding Information: S. Sousa is grateful to Fundação para a Ciência e a Tecnologia and European Social Fund through Programa Operacional Capital Humano for the Ph.D . grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). Publisher Copyright: © 2023 Elsevier Ltd
publishDate 2023
dc.date.none.fl_str_mv 2023-09-27T22:25:16Z
2023-08
2023-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158379
url http://hdl.handle.net/10362/158379
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0952-3278
PURE: 70039444
https://doi.org/10.1016/j.plefa.2023.102581
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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