Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation

Detalhes bibliográficos
Autor(a) principal: Martins, Fátima O.
Data de Publicação: 2021
Outros Autores: Sacramento, Joana F., Olea, Elena, Melo, Bernardete F., Prieto-Lloret, Jesus, Obeso, Ana, Rocher, Asuncion, Matafome, Paulo, Monteiro, Emilia C., Conde, Silvia V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/124955
Resumo: Funding Information: Funding: The present study was supported by grant reference BFU2015-70616-R (MINECO/FEDER; DGICYT), and VA106G18 (JCyL), Spain and by the Portuguese Foundation for Science and Technology with contracts for Fátima O. Martins (CEECIND/04266/2017) and Joana F. Sacramento (CEEC IND/02428/2018) and a PhD Grant for Bernardete F. Melo (PD/BD/128336/2017). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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spelling Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulationAdipose tissueHypoxiaInflammationInsulin resistanceMetabolic dysfunctionObstructive sleep apneaOxidative stressBiochemistryPhysiologyMolecular BiologyClinical BiochemistryCell BiologySDG 3 - Good Health and Well-beingFunding Information: Funding: The present study was supported by grant reference BFU2015-70616-R (MINECO/FEDER; DGICYT), and VA106G18 (JCyL), Spain and by the Portuguese Foundation for Science and Technology with contracts for Fátima O. Martins (CEECIND/04266/2017) and Joana F. Sacramento (CEEC IND/02428/2018) and a PhD Grant for Bernardete F. Melo (PD/BD/128336/2017). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Several studies demonstrated a link between obstructive sleep apnea (OSA) and the development of insulin resistance. However, the main event triggering insulin resistance in OSA remains to be clarified. Herein, we investigated the effect of mild and severe chronic intermittent hypoxia (CIH) on whole-body metabolic deregulation and visceral adipose tissue dysfunction. Moreover, we studied the contribution of obesity to CIH-induced dysmetabolic states. Experiments were performed in male Wistar rats submitted to a control and high-fat (HF) diet. Two CIH protocols were tested: A mild CIH paradigm (5/6 hypoxic (5% O2) cycles/h, 10.5 h/day) during 35 days and a severe CIH paradigm (30 hypoxic (5% O2) cycles, 8 h/day) during 15 days. Fasting glycemia, insulinemia, insulin sensitivity, weight, and fat mass were assessed. Adipose tissue hypoxia, inflammation, angiogenesis, oxidative stress, and metabolism were investigated. Mild and severe CIH increased insulin levels and induced whole-body insulin resistance in control animals, effects not associated with weight gain. In control animals, CIH did not modify adipocytes perimeter as well as adipose tissue hypoxia, angiogenesis, inflammation or oxidative stress. In HF animals, severe CIH attenuated the increase in adipocytes perimeter, adipose tissue hypoxia, angiogenesis, and dysmetabolism. In conclusion, adipose tissue dysfunction is not the main trigger for initial dysmetabolism in CIH. CIH in an early stage might have a protective role against the deleterious effects of HF diet on adipose tissue metabolism.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMartins, Fátima O.Sacramento, Joana F.Olea, ElenaMelo, Bernardete F.Prieto-Lloret, JesusObeso, AnaRocher, AsuncionMatafome, PauloMonteiro, Emilia C.Conde, Silvia V.2021-09-22T02:13:30Z2021-082021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/124955eng2076-3921PURE: 33695859https://doi.org/10.3390/antiox10081233info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:56:17Zoai:run.unl.pt:10362/124955Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:56:17Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
spellingShingle Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
Martins, Fátima O.
Adipose tissue
Hypoxia
Inflammation
Insulin resistance
Metabolic dysfunction
Obstructive sleep apnea
Oxidative stress
Biochemistry
Physiology
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
title_short Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title_full Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title_fullStr Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title_full_unstemmed Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title_sort Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
author Martins, Fátima O.
author_facet Martins, Fátima O.
Sacramento, Joana F.
Olea, Elena
Melo, Bernardete F.
Prieto-Lloret, Jesus
Obeso, Ana
Rocher, Asuncion
Matafome, Paulo
Monteiro, Emilia C.
Conde, Silvia V.
author_role author
author2 Sacramento, Joana F.
Olea, Elena
Melo, Bernardete F.
Prieto-Lloret, Jesus
Obeso, Ana
Rocher, Asuncion
Matafome, Paulo
Monteiro, Emilia C.
Conde, Silvia V.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Martins, Fátima O.
Sacramento, Joana F.
Olea, Elena
Melo, Bernardete F.
Prieto-Lloret, Jesus
Obeso, Ana
Rocher, Asuncion
Matafome, Paulo
Monteiro, Emilia C.
Conde, Silvia V.
dc.subject.por.fl_str_mv Adipose tissue
Hypoxia
Inflammation
Insulin resistance
Metabolic dysfunction
Obstructive sleep apnea
Oxidative stress
Biochemistry
Physiology
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
topic Adipose tissue
Hypoxia
Inflammation
Insulin resistance
Metabolic dysfunction
Obstructive sleep apnea
Oxidative stress
Biochemistry
Physiology
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
description Funding Information: Funding: The present study was supported by grant reference BFU2015-70616-R (MINECO/FEDER; DGICYT), and VA106G18 (JCyL), Spain and by the Portuguese Foundation for Science and Technology with contracts for Fátima O. Martins (CEECIND/04266/2017) and Joana F. Sacramento (CEEC IND/02428/2018) and a PhD Grant for Bernardete F. Melo (PD/BD/128336/2017). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-22T02:13:30Z
2021-08
2021-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/124955
url http://hdl.handle.net/10362/124955
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3921
PURE: 33695859
https://doi.org/10.3390/antiox10081233
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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