Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/55191 |
Resumo: | Copyright © 2022 Locquet, Spoor, Crijns, van der Harst, Eraso, Guedea, Fiuza, Santos, Combs, Borm, Mousseaux, Gencer, Frija, Cardis, Langendijk and Jacob. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART studyEARLY-HEART cohortMEDIRADBreast cancerCardiac dysfunctionDosimetryRadiotherapyStrain imagingCopyright © 2022 Locquet, Spoor, Crijns, van der Harst, Eraso, Guedea, Fiuza, Santos, Combs, Borm, Mousseaux, Gencer, Frija, Cardis, Langendijk and Jacob. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Background: In the case of breast cancer (BC), radiotherapy (RT) helps reduce locoregional recurrence and BC-related deaths but can lead to cardiotoxicity, resulting in an increased risk of long-term major cardiovascular events. It is therefore of primary importance to early detect subclinical left ventricular (LV) dysfunction in BC patients after RT and to determine the dose-response relationships between cardiac doses and these events. Methods: Within the frame of the MEDIRAD European project (2017-2022), the prospective multicenter EARLY-HEART study (ClinicalTrials.gov Identifier: NCT03297346) included chemotherapy naïve BC women aged 40-75 years and treated with lumpectomy and adjuvant RT. Myocardial strain analysis was provided using speckle-tracking echocardiography performed at baseline and 6 months following RT. A global longitudinal strain (GLS) reduction >15% between baseline and follow-up was defined as a GLS-based subclinical LV dysfunction. Individual patient dose distributions were obtained using multi-atlas-based auto-segmentation of the heart. Dose-volume parameters were studied for the whole heart (WH) and left ventricle (LV). Results: The sample included 186 BC women (57.5 ± 7.9 years, 64% left-sided BC). GLS-based subclinical LV dysfunction was observed in 22 patients (14.4%). These patients had significantly higher cardiac exposure regarding WH and LV doses compared to patients without LV dysfunction (for mean WH dose: 2.66 ± 1.75 Gy versus 1.64 ± 0.96 Gy, p = 0.01). A significantly increased risk of subclinical LV dysfunction was observed with the increase in the dose received to the WH [ORs from 1.13 (V5) to 1.74 (Dmean); p <0.01] and to the LV [ORs from 1.10 (V5) to 1.46 (Dmean); p <0.01]. Based on ROC analysis, the LV-V5 parameter may be the best predictor of the short-term onset of subclinical LV dysfunction. Conclusion: These results highlighted that all cardiac doses were strongly associated with the occurrence of subclinical LV dysfunction arising 6 months after BC RT. Whether measurements of GLS at baseline and 6 months after RT combined with cardiac doses can early predict efficiently subclinical events occurring 24 months after RT remains to be investigated.The European Community’s Horizon 2020 Programme supported the EARLY-HEART study conducted in the frame of the MEDIRAD - Implications of Medical Low Dose Radiation Exposure - project spanning from 2017 to 2021 granted by the Euratom Research and Training Programme 2014-2014 under agreement No. 755523.FrontiersRepositório da Universidade de LisboaLocquet, MédéaSpoor, DaanCrijns, Annevan der Harst, PimEraso, ArantxaGuedea, FerranFiuza, ManuelaSantos, Susana Constantino RosaCombs, StephanieBorm, KaiMousseaux, ElieGencer, UmitFrija, GuyCardis, ElisabethLangendijk, HansJacob, Sophie2022-11-22T12:03:35Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55191engFront Oncol. 2022 Jun 28;12:88367910.3389/fonc.2022.8836792234-943Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:48Zoai:repositorio.ul.pt:10451/55191Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:46.108315Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART study |
| title |
Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART study |
| spellingShingle |
Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART study Locquet, Médéa EARLY-HEART cohort MEDIRAD Breast cancer Cardiac dysfunction Dosimetry Radiotherapy Strain imaging |
| title_short |
Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART study |
| title_full |
Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART study |
| title_fullStr |
Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART study |
| title_full_unstemmed |
Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART study |
| title_sort |
Subclinical left ventricular dysfunction detected by speckle-tracking echocardiography in breast cancer patients treated with radiation therapy: a six-month follow-up analysis - MEDIRAD EARLY HEART study |
| author |
Locquet, Médéa |
| author_facet |
Locquet, Médéa Spoor, Daan Crijns, Anne van der Harst, Pim Eraso, Arantxa Guedea, Ferran Fiuza, Manuela Santos, Susana Constantino Rosa Combs, Stephanie Borm, Kai Mousseaux, Elie Gencer, Umit Frija, Guy Cardis, Elisabeth Langendijk, Hans Jacob, Sophie |
| author_role |
author |
| author2 |
Spoor, Daan Crijns, Anne van der Harst, Pim Eraso, Arantxa Guedea, Ferran Fiuza, Manuela Santos, Susana Constantino Rosa Combs, Stephanie Borm, Kai Mousseaux, Elie Gencer, Umit Frija, Guy Cardis, Elisabeth Langendijk, Hans Jacob, Sophie |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Locquet, Médéa Spoor, Daan Crijns, Anne van der Harst, Pim Eraso, Arantxa Guedea, Ferran Fiuza, Manuela Santos, Susana Constantino Rosa Combs, Stephanie Borm, Kai Mousseaux, Elie Gencer, Umit Frija, Guy Cardis, Elisabeth Langendijk, Hans Jacob, Sophie |
| dc.subject.por.fl_str_mv |
EARLY-HEART cohort MEDIRAD Breast cancer Cardiac dysfunction Dosimetry Radiotherapy Strain imaging |
| topic |
EARLY-HEART cohort MEDIRAD Breast cancer Cardiac dysfunction Dosimetry Radiotherapy Strain imaging |
| description |
Copyright © 2022 Locquet, Spoor, Crijns, van der Harst, Eraso, Guedea, Fiuza, Santos, Combs, Borm, Mousseaux, Gencer, Frija, Cardis, Langendijk and Jacob. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-22T12:03:35Z 2022 2022-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/55191 |
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http://hdl.handle.net/10451/55191 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Front Oncol. 2022 Jun 28;12:883679 10.3389/fonc.2022.883679 2234-943X |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Frontiers |
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Frontiers |
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